MPD: Project measures / variables set: Rusyn2 TCA

Project measures / variables set: Rusyn2 TCA_tce

ID, description, units	MPD:36175 TCA_tce trichloroacetic acid (serum TCA) [nmol/mL] trichloroethylene study
Measures	• time after treatment: 2h • 8h • 24h
Data set, strains	Rusyn2 inbred 15 strains sex: m age: 7wks
Procedure	drug and metabolite quantification
Comparison	timecourse but different cohorts
Ontology mappings	VT:0002121 metabolism trait VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0008872 abnormal physiological response to xenobiotic MP:0012696 abnormal trichloroethene metabolism

Values Means Δ Means Z-scores

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Rusyn2 - trichloroacetic acid (serum TCA)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
time	2	6371617.406	3185808.703	102.1026	< 0.0001
strain	8	1994750.8217	249343.8527	7.9913	< 0.0001
time:strain	16	3604759.8983	225297.4936	7.2206	< 0.0001
Residuals	49	1528899.7933	31202.0366

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Rusyn2	36175	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (serum TCA) [nmol/mL] 2h after treatment TCA_2_tce	inbred	15	m	7wks
Rusyn2	36176	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (serum TCA) [nmol/mL] 8h after treatment TCA_8_tce	inbred	15	m	7wks
Rusyn2	36177	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (serum TCA) [nmol/mL] 24h after treatment TCA_24_tce	inbred	13	m	7wks