MPD: Project measures / variables set: Rusyn2 DCV_glutathione

Project measures / variables set: Rusyn2 DCV_glutathione_tce

ID, description, units	MPD:36195 DCV_glutathione_tce DCV glutathione (serum DCVG x 10^-3) [nmol/mL] trichloroethylene study
Measures	• time after treatment: 2h • 8h • 24h
Data set, strains	Rusyn2 inbred 17 strains sex: m age: 7wks
Procedure	drug and metabolite quantification
Comparison	timecourse but different cohorts
Ontology mappings	VT:0002121 metabolism trait VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0008872 abnormal physiological response to xenobiotic MP:0011601 abnormal glutathione peroxidase activity

Values Means Δ Means Z-scores

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Rusyn2 - DCV glutathione (serum DCVG x 10^-3)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
time	2	325.9674	162.9837	11.4809	0.0004
time:strain	6	576.0786	96.0131	6.7634	0.0004
Residuals	21	298.1173	14.1961
strain	3	260.8656	86.9552	6.1253	0.0037

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Rusyn2	36195	drug and metabolite quantification	trichloroethylene	DCV glutathione (serum DCVG x 10^-3) [nmol/mL] 2h after treatment DCV_glutathione2_tce	inbred	15	m	7wks
Rusyn2	36196	drug and metabolite quantification	trichloroethylene	DCV glutathione (serum DCVG x 10^-3) [nmol/mL] 8h after treatment DCV_glutathione8_tce	inbred	16	m	7wks
Rusyn2	36197	drug and metabolite quantification	trichloroethylene	DCV glutathione (serum DCVG x 10^-3) [nmol/mL] 24h after treatment DCV_glutathione24_tce	inbred	11	m	7wks