Project measures / variables set:   Threadgill2   APAP_Sulf_300

ID, description, units MPD:39638   APAP_Sulf_300   serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen   [µg/mL]  
acetaminophen study
Measures
• baseline    • 0.5h    • 1h    • 2h    • 3h    • 6h
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Comparisontimecourse, same cohort
Ontology mappings

  SIDE-BY-SIDE STRAIN CURVES
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  OVERLAPPING STRAIN CURVES
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Threadgill2 - serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen



  ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary          "within" = Within error     "between" = Between Error (Animal ID)

Factor DF Sum of squares Mean sum of squares F value p-value (Pr>F)
between   strain 4 1530.9347 382.7337 5.5808 0.0047
between   Residuals 17 1165.8614 68.5801
within   group 5 6782.438 1356.4876 68.8973 < 0.0001
within   group:strain 20 1243.1454 62.1573 3.157 0.0001
within   Residuals 85 1673.5261 19.6885

Q-Q normality assessment based on residuals

  


  INDIVIDUAL MEASURES
ProjectIDTreatmentMeasure / Variable Description PanelStrains
tested		SexAge
Threadgill2 39638 drug and metabolite quantification acetaminophen serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen   [µg/mL]   baseline  APAP_Sulf_300_0 inbred 5 m 6-8wks
Threadgill2 39640 drug and metabolite quantification acetaminophen serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen   [µg/mL]   0.5h  APAP_Sulf_300_0.5 inbred 5 m 6-8wks
Threadgill2 39641 drug and metabolite quantification acetaminophen serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen   [µg/mL]   1h  APAP_Sulf_300_1 inbred 5 m 6-8wks
Threadgill2 39642 drug and metabolite quantification acetaminophen serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen   [µg/mL]   2h  APAP_Sulf_300_2 inbred 5 m 6-8wks
Threadgill2 39643 drug and metabolite quantification acetaminophen serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen   [µg/mL]   3h  APAP_Sulf_300_3 inbred 5 m 6-8wks
Threadgill2 39644 drug and metabolite quantification acetaminophen serum acetaminophen sulfate (APAP-sulfate), 300 mg/mL dose acetaminophen   [µg/mL]   6h  APAP_Sulf_300_6 inbred 5 m 6-8wks



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