MPD: Project measures / variables set: Rusyn2 DCV_cysteine

Project measures / variables set: Rusyn2 DCV_cysteine_tce

ID, description, units	MPD:36185 DCV_cysteine_tce DCV cysteine (serum DCVC x 10^-3) [nmol/mL] trichloroethylene study
Measures	• time after treatment: 2h • 8h • 24h
Data set, strains	Rusyn2 inbred 16 strains sex: m age: 7wks
Procedure	drug and metabolite quantification
Comparison	timecourse but different cohorts
Ontology mappings	VT:0002121 metabolism trait VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0005332 abnormal amino acid level MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Rusyn2 - DCV cysteine (serum DCVC x 10^-3)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
time	2	4.3018	2.1509	77.2886	< 0.0001
time:strain	2	4.184	2.092	75.171	< 0.0001
Residuals	9	0.2505	0.0278
strain	1	4.7243	4.7243	169.7581	< 0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Rusyn2	36185	drug and metabolite quantification	trichloroethylene	DCV cysteine (serum DCVC x 10^-3) [nmol/mL] 2h after treatment DCV_cysteine2_tce	inbred	15	m	7wks
Rusyn2	36186	drug and metabolite quantification	trichloroethylene	DCV cysteine (serum DCVC x 10^-3) [nmol/mL] 8h after treatment DCV_cysteine8_tce	inbred	13	m	7wks
Rusyn2	36187	drug and metabolite quantification	trichloroethylene	DCV cysteine (serum DCVC x 10^-3) [nmol/mL] 24h after treatment DCV_cysteine24_tce	inbred	7	m	7wks