Project measures / variables set:   Threadgill2   APAP_Glc_300

ID, description, units MPD:39639   APAP_Glc_300   serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]  
acetaminophen study
Measures
• baseline    • 0.5h    • 1h    • 2h    • 3h    • 6h
Data set, strains Threadgill2   inbred   5 strains     sex: m     age: 6-8wks
Procedure drug and metabolite quantification
Comparisontimecourse, same cohort
Ontology mappings

  SIDE-BY-SIDE STRAIN CURVES
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  OVERLAPPING STRAIN CURVES
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Threadgill2 - serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen



  ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary          "within" = Within error     "between" = Between Error (Animal ID)

Factor DF Sum of squares Mean sum of squares F value p-value (Pr>F)
between   strain 4 81787.8795 20446.9699 2.8196 0.0581
between   Residuals 17 123277.4952 7251.6174
within   group 5 2287283.8744 457456.7749 198.6019 < 0.0001
within   group:strain 20 128878.1413 6443.9071 2.7976 0.0005
within   Residuals 85 195787.7518 2303.3853

Q-Q normality assessment based on residuals

  


  INDIVIDUAL MEASURES
ProjectIDTreatmentMeasure / Variable Description PanelStrains
tested		SexAge
Threadgill2 39639 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]   baseline  APAP_Glc_300_0 inbred 5 m 6-8wks
Threadgill2 39645 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]   0.5h  APAP_Glc_300_0.5 inbred 5 m 6-8wks
Threadgill2 39646 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]   1h  APAP_Glc_300_1 inbred 5 m 6-8wks
Threadgill2 39647 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]   2h  APAP_Glc_300_2 inbred 5 m 6-8wks
Threadgill2 39648 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]   3h  APAP_Glc_300_3 inbred 5 m 6-8wks
Threadgill2 39649 drug and metabolite quantification acetaminophen serum acetaminophen glucuronide (APAP-Glc), 300 mg/mL dose acetaminophen   [µg/mL]   6h  APAP_Glc_300_6 inbred 5 m 6-8wks



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