MPD: Project measures / variables set: Rusyn2 DCA

Project measures / variables set: Rusyn2 DCA_tce

ID, description, units	MPD:36167 DCA_tce dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] trichloroethylene study
Measures	• time after treatment: 2h • 8h • 24h
Data set, strains	Rusyn2 inbred 15 strains sex: m age: 7wks
Procedure	drug and metabolite quantification
Comparison	timecourse but different cohorts
Ontology mappings	VT:0002121 metabolism trait VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0008872 abnormal physiological response to xenobiotic MP:0012696 abnormal trichloroethene metabolism

Values Means Δ Means Z-scores

Graph Type Points Bars

Dimensions Width: × Height: px

Plot Options Hide Error Bars Strains on X-axis

Strains

measured value [nmol/mL x 10^-3]

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
time	2	339962.9718	169981.4859	6.1264	0.0039
strain	10	343092.0188	34309.2019	1.2366	0.2879
time:strain	20	558508.1963	27925.4098	1.0065	0.4692
Residuals	58	1609250.0	27745.6897

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Rusyn2	36167	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] 2h after treatment DCA_2_tce	inbred	15	m	7wks
Rusyn2	36168	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] 8h after treatment DCA_8_tce	inbred	15	m	7wks
Rusyn2	36169	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] 24h after treatment DCA_24_tce	inbred	15	m	7wks