Gould1: Drug study: Antidepressant-like responses to lithium in males of 8 inbred mouse strains and 3 outbred stocks (2011)

Can A, Blackwell RA, Piantadosi SC, Dao DT, O'Donnell KC, Gould TD. Antidepressant-like responses to lithium in genetically diverse mouse strains. Genes Brain Behav. 2011 Jun;10(4):434-43. doi: 10.1111/j.1601-183X.2011.00682.x. Epub 2011 Mar 1.   PubMed 21306560     FullText


         
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Investigators Adem Can       University of Maryland,  Baltimore, MD
Todd D Gould       University of Maryland,  Baltimore, MD
Participants Blackwell RA, Piantadosi SC, Dao DT, O'Donnell KC
ContactTodd D Gould     tgould@psych.umaryland.edu     Lab web site
AcknowledgementsFunding provided by NIH MH084043
Project type Phenotype strain survey data set
MPD identifiersGould1     MPD:374
Data changelog No updates/corrections.       Initial release date: 07/2011.
Formatted citation
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Responses to lithium were assessed using the forced swim test (FST) based on the hypothesis that lithium-responsive mice are less prone to behavioral despair as demonstrated by sustained mobility during FST (immobility is associated with behavioral despair and depression). Following FST, blood and brain samples were collected to measure lithium concentration using flame photometry.

There were 4 treatment cohorts: saline control and acute administration of lithium 200, 300, and 400 mg/kg i.p.

Procedures conducted:
• forced swim test  Lithium (several doses) vs. control. 6 min test.
• drug and metabolite quantification  Lithium concentration in brain tissue and blood serum after lithium (several doses).

Mice: inbred   11 strains   ♂   age 7-8wks   4 experimental groups

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Procedure / Protocol
Treatment
Phenotype Measure / Variable (click to view)
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No. of Strains
Sex
Age
Sample Size (Avg)
    Gould1 forced swim test lithium duration of immobility   [s]  immob   37401     lithium dose [mg/kg]:    0(saline)    200    300    400 inbred 11 m 7-8wks N=8
    Gould1 drug and metabolite quantification lithium serum lithium concentration   [mmol/L]  blood_lithium   37405     lithium dose [mg/kg]:    200    300    400 inbred 11 m 7-8wks N=8
    Gould1 drug and metabolite quantification lithium brain lithium concentration   [mmol/L]  brain_lithium   37408     lithium dose [mg/kg]:    200    300    400 inbred 11 m 7-8wks N=8
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