MPD: Project measures / variables set: Threadgill2 APAP_Sulf

Project measures / variables set: Threadgill2 APAP_Sulf_50

ID, description, units	MPD:39616 APAP_Sulf_50 serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] acetaminophen study
Measures	• baseline • 0.5h • 1h • 2h • 3h • 6h
Data set, strains	Threadgill2 inbred 5 strains sex: m age: 6-8wks
Procedure	drug and metabolite quantification
Comparison	timecourse, same cohort
Ontology mappings	VT:0002121 metabolism trait VT:0010487 response to xenobiotic stimulus trait MA:0002502 serum MP:0008872 abnormal physiological response to xenobiotic MP:0012691 abnormal acetaminophen metabolism

Values Means Δ Means Z-scores

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Threadgill2 - serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between strain	4	26.8599	6.715	1.086	0.3985
between Residuals	15	92.7523	6.1835
within group	5	365.5031	73.1006	36.7	< 0.0001
within group:strain	20	60.8091	3.0405	1.5265	0.0974
within Residuals	75	149.3883	1.9918

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Threadgill2	39616	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] baseline APAP_Sulf_50_0	inbred	5	m	6-8wks
Threadgill2	39617	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] 0.5h APAP_Sulf_50_0.5	inbred	5	m	6-8wks
Threadgill2	39618	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] 1h APAP_Sulf_50_1	inbred	5	m	6-8wks
Threadgill2	39619	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] 2h APAP_Sulf_50_2	inbred	5	m	6-8wks
Threadgill2	39620	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] 3h APAP_Sulf_50_3	inbred	5	m	6-8wks
Threadgill2	39621	drug and metabolite quantification	acetaminophen	serum acetaminophen sulfate (APAP-sulfate), 50 mg/mL dose acetaminophen [µg/mL] 6h APAP_Sulf_50_6	inbred	5	m	6-8wks