MPD: Project measures / variables set: Gould2 nicotine

Project measures / variables set: Gould2 nicotine

ID, description, units	MPD:47101 nicotine plasma nicotine [ng/mL] nicotine study
Measures	• acute 0.09mg dose • chronic 6.3mg dose
Data set, strains	Gould2 inbred 8 strains sex: m age: 8-12wks
Procedure	drug and metabolite quantification
Comparison	multiple dosage cohorts but no control group
Ontology mappings	VT:0002121 metabolism trait VT:0010721 response to nicotine trait MA:0002501 plasma MP:0008872 abnormal physiological response to xenobiotic MP:0012695 abnormal nicotine metabolism

Values Means Δ Means Z-scores

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Gould2 - plasma nicotine

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
group	1	10967.8904	10967.8904	165.3676	< 0.0001
group:strain	7	2582.9865	368.9981	5.5635	< 0.0001
Residuals	142	9418.0486	66.3243
strain	7	2762.1894	394.5985	5.9495	< 0.0001

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Gould2	47101	drug and metabolite quantification	nicotine	plasma nicotine [ng/mL] acute 0.09mg dose nicotine_acu	inbred	8	m
Gould2	47102	drug and metabolite quantification	nicotine	plasma nicotine [ng/mL] chronic 6.3mg dose nicotine_chr	inbred	8	m