MPD: Phenotype measures mapped to VT:0002338, pulmonary ventilation trait

Sort/ Pick	Data set	Procedure / Protocol	Drug or Challenge	Phenotype Measure	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Ackerman1:1	Ackerman1	ventilator	methacholine	individual pulmonary resistance values, a percentage of baseline for the 100 µg/kg dose [%] RL100 15601	QTL population		f	7-8wks	N=372	2005

Ackerman1:2	Ackerman1	ventilator	methacholine	individual pulmonary resistance, a percentage of baseline for the 330 µg/kg dose [%] RL330 15602	QTL population		f	7-8wks	N=372	2005

Ackerman1:3	Ackerman1	ventilator	methacholine	individual pulmonary resistance, a percentage of baseline for the 1000 µg/kg dose [%] RL1000 15603	QTL population		f	7-8wks	N=372	2005

Ackerman1:4	Ackerman1	ventilator	methacholine	individual pulmonary resistance, a percentage of baseline for the 3300 µg/kg dose [%] RL3300 15604	QTL population		f	7-8wks	N=372	2005

Ackerman1:5	Ackerman1	ventilator	methacholine	effective doses of methacholine required for a 1.50-fold increase in R_L), log transformed [log(n)] logED150 15605	QTL population		f	7-8wks	N=372	2005

Berndt1:1	Berndt1	ventilator	(none)	airway resistance (naive, untreated, H₂O pressure) [cm/mL/s] airway_res 34201	inbred	36	both	9-12wks	N=9	2010

Berndt1:10	Berndt1	ventilator	methacholine	airway resistance (H₂O pressure) [cm/mL/s] airway_res_series 34210 baseline MCh challenge (mg/mL): 1 3 10 30	inbred	36	both	9-12wks	N=8	2010

Berndt1:21	Berndt1	ventilator	methacholine	airway resistance (as % of baseline, H₂O pressure) [%] pct_res 34221 MCh challenge (mg/mL): 1 3 10 30	inbred	36	both	9-12wks	N=8	2010

Berndt2:1	Berndt2	plethysmography	methacholine	minute ventilation [mL/min] min_vent 35101 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:8	Berndt2	plethysmography	methacholine	breath frequency [n/min] breath_freq 35108 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:14	Berndt2	plethysmography	methacholine	inspiratory phase [s] inspiratory 35114 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:21	Berndt2	plethysmography	methacholine	expiratory phase [s] expiratory 35121 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:28	Berndt2	plethysmography	methacholine	respiratory cycle [s] tot_respi 35128 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:34	Berndt2	plethysmography	methacholine	duty cycle [ratio] duty_cycle 35134 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:41	Berndt2	plethysmography	methacholine	inspiratory flow rate [mL/kg/s] insp_flow 35141 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:48	Berndt2	plethysmography	methacholine	expiratory flow rate [mL/kg/s] exp_flow 35148 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:54	Berndt2	plethysmography	methacholine	respiratory flow rate [mL/kg/s] resp_flow 35154 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:61	Berndt2	plethysmography	methacholine	enhanced pause penh 35161 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:68	Berndt2	plethysmography	methacholine	tidal volume [mL] tidal_vol 35168 saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:81	Berndt2	ventilator	methacholine	airway resistance (H₂0 pressure) [cm/mL/s] airway_res 35181 saline 1 MCh 3 MCh 10 MCh 30 MCh response index	inbred	29	both	9-12wks	N=9	2010

Mathes1:9	Mathes1	monitoring system	(none)	nocturnal respiratory exchange ratio (RER) prior to wheel running (VCO2:VO2) [ratio] RER_pre 45209	CC pre w/par	138	m	10-12wks	N=1	2011

McMullan7:1	McMullan7	monitoring system	(none)	mean oxygen consumption at start of experiment, during day [mL/h] VO2_d_start 61601 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:4	McMullan7	monitoring system	exercise	mean oxygen consumption after 4 wks of treatment, during day [mL/h] VO2_d_end 61604 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:7	McMullan7	monitoring system	(none)	mean oxygen consumption at start of experiment, during night [mL/h] VO2_n_start 61607 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:11	McMullan7	monitoring system	exercise	mean oxygen consumption after 4 wks of treatment, during night [mL/h] VO2_n_end 61611 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:14	McMullan7	monitoring system	(none)	mean carbon dioxide production at start of experiment, during day [mL/h] VCO2_d_start 61614 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:17	McMullan7	monitoring system	exercise	mean carbon dioxide production after 4 wks of treatment, during day [mL/h] VCO2_d_end 61617 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:21	McMullan7	monitoring system	(none)	mean carbon dioxide production at start of experiment, during night [mL/h] VCO2_n_start 61621 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:24	McMullan7	monitoring system	exercise	mean carbon dioxide production after 4 wks of treatment, during night [mL/h] VCO2_n_end 61624 no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

Schulz1:30	Schulz1	ventilator	(none)	Fowler dead space volume to total lung capacity [µL/µL] ratio_VDF_TLC 1630	inbred	7	both	12-14wks	N=15	2000

Schulz1:31	Schulz1	ventilator	(none)	Fowler dead space volume to body weight [µL/g] ratio_VDF_bw 1631	inbred	7	both	12-14wks	N=14	2000

Schulz1:32	Schulz1	ventilator	(none)	Fowler dead space volume [µL] VDF 1632	inbred	7	both	12-14wks	N=15	2000

Seburn1:8	Seburn1	monitoring system	(none)	oxygen volume, 3 day test [mL/kg/h] VO2 9208 daily light dark	inbred	16	both	7-9wks	N=8	2001

Seburn1:11	Seburn1	monitoring system	(none)	carbon dioxide volume, 3 day test [mL/kg/h] VCO2 9211 daily light dark	inbred	14	both	7-9wks	N=8	2001

Ackerman1

ventilator

methacholine

individual pulmonary resistance values, a percentage of baseline for the 100 µg/kg dose [%] RL100 15601

QTL population

f

7-8wks

N=372

2005

Ackerman1

ventilator

methacholine

individual pulmonary resistance, a percentage of baseline for the 330 µg/kg dose [%] RL330 15602

QTL population

f

7-8wks

N=372

2005

Ackerman1

ventilator

methacholine

individual pulmonary resistance, a percentage of baseline for the 1000 µg/kg dose [%] RL1000 15603

QTL population

f

7-8wks

N=372

2005

Ackerman1

ventilator

methacholine

individual pulmonary resistance, a percentage of baseline for the 3300 µg/kg dose [%] RL3300 15604

QTL population

f

7-8wks

N=372

2005

Ackerman1

ventilator

methacholine

effective doses of methacholine required for a 1.50-fold increase in R_L), log transformed [log(n)] logED150 15605

QTL population

f

7-8wks

N=372

2005

Berndt1

ventilator

(none)

airway resistance (naive, untreated, H₂O pressure) [cm/mL/s] airway_res 34201

inbred

36

both

9-12wks

N=9

2010

Berndt1

ventilator

methacholine

airway resistance (H₂O pressure) [cm/mL/s] airway_res_series 34210 baseline MCh challenge (mg/mL): 1 3 10 30

inbred

36

both

9-12wks

N=8

2010

Berndt1

ventilator

methacholine

airway resistance (as % of baseline, H₂O pressure) [%] pct_res 34221 MCh challenge (mg/mL): 1 3 10 30

inbred

36

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

minute ventilation [mL/min] min_vent 35101 saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

breath frequency [n/min] breath_freq 35108 saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

inspiratory phase [s] inspiratory 35114 saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

expiratory phase [s] expiratory 35121 saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

respiratory cycle [s] tot_respi 35128 saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

duty cycle [ratio] duty_cycle 35134 saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

inspiratory flow rate [mL/kg/s] insp_flow 35141 saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

expiratory flow rate [mL/kg/s] exp_flow 35148 saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

respiratory flow rate [mL/kg/s] resp_flow 35154 saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

enhanced pause penh 35161 saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

tidal volume [mL] tidal_vol 35168 saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

ventilator

methacholine

airway resistance (H₂0 pressure) [cm/mL/s] airway_res 35181 saline 1 MCh 3 MCh 10 MCh 30 MCh response index

inbred

29

both

9-12wks

N=9

2010

Mathes1

monitoring system

(none)

nocturnal respiratory exchange ratio (RER) prior to wheel running (VCO2:VO2) [ratio] RER_pre 45209

CC pre w/par

138

m

10-12wks

N=1

2011

McMullan7

monitoring system

(none)

mean oxygen consumption at start of experiment, during day [mL/h] VO2_d_start 61601 no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

exercise

mean oxygen consumption after 4 wks of treatment, during day [mL/h] VO2_d_end 61604 no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

(none)

mean oxygen consumption at start of experiment, during night [mL/h] VO2_n_start 61607 no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

exercise

mean oxygen consumption after 4 wks of treatment, during night [mL/h] VO2_n_end 61611 no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

(none)

mean carbon dioxide production at start of experiment, during day [mL/h] VCO2_d_start 61614 no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

exercise

mean carbon dioxide production after 4 wks of treatment, during day [mL/h] VCO2_d_end 61617 no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

(none)

mean carbon dioxide production at start of experiment, during night [mL/h] VCO2_n_start 61621 no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

exercise

mean carbon dioxide production after 4 wks of treatment, during night [mL/h] VCO2_n_end 61624 no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

Schulz1

ventilator

(none)

Fowler dead space volume to total lung capacity [µL/µL] ratio_VDF_TLC 1630

inbred

7

both

12-14wks

N=15

2000

Schulz1

ventilator

(none)

Fowler dead space volume to body weight [µL/g] ratio_VDF_bw 1631

inbred

7

both

12-14wks

N=14

2000

Schulz1

ventilator

(none)

Fowler dead space volume [µL] VDF 1632

inbred

7

both

12-14wks

N=15

2000

Seburn1

monitoring system

(none)

oxygen volume, 3 day test [mL/kg/h] VO2 9208 daily light dark

inbred

16

both

7-9wks

N=8

2001

Seburn1

monitoring system

(none)

carbon dioxide volume, 3 day test [mL/kg/h] VCO2 9211 daily light dark

inbred

14

both

7-9wks

N=8

2001

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