MPD: Phenotype measures associated with VT:0002338

Data set	MPD ID	Procedure / Protocol	Drug or Challenge	Phenotype Measure	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Ackerman1	15601	ventilator	methacholine	individual pulmonary resistance values, a percentage of baseline for the 100 µg/kg dose [%] RL100	QTL population		f	7-8wks	N=372	2005

Ackerman1	15602	ventilator	methacholine	individual pulmonary resistance, a percentage of baseline for the 330 µg/kg dose [%] RL330	QTL population		f	7-8wks	N=372	2005

Ackerman1	15603	ventilator	methacholine	individual pulmonary resistance, a percentage of baseline for the 1000 µg/kg dose [%] RL1000	QTL population		f	7-8wks	N=372	2005

Ackerman1	15604	ventilator	methacholine	individual pulmonary resistance, a percentage of baseline for the 3300 µg/kg dose [%] RL3300	QTL population		f	7-8wks	N=372	2005

Ackerman1	15605	ventilator	methacholine	effective doses of methacholine required for a 1.50-fold increase in R_L), log transformed [log(n)] logED150	QTL population		f	7-8wks	N=372	2005

Berndt1	34201	ventilator	(none)	airway resistance (naive, untreated, H₂O pressure) [cm/mL/s] airway_res	inbred	36	both	9-12wks	N=9	2010

Berndt1	34210	ventilator	methacholine	airway resistance (H₂O pressure) [cm/mL/s] baseline MCh challenge (mg/mL): 1 3 10 30	inbred	36	both	9-12wks	N=8	2010

Berndt1	34221	ventilator	methacholine	airway resistance (as % of baseline, H₂O pressure) [%] MCh challenge (mg/mL): 1 3 10 30	inbred	36	both	9-12wks	N=8	2010

Berndt2	35101	plethysmography	methacholine	minute ventilation [mL/min] saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2	35108	plethysmography	methacholine	breath frequency [n/min] saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2	35114	plethysmography	methacholine	inspiratory phase [s] saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2	35121	plethysmography	methacholine	expiratory phase [s] saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2	35128	plethysmography	methacholine	respiratory cycle [s] saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2	35134	plethysmography	methacholine	duty cycle [ratio] saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2	35141	plethysmography	methacholine	inspiratory flow rate [mL/kg/s] saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2	35148	plethysmography	methacholine	expiratory flow rate [mL/kg/s] saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2	35154	plethysmography	methacholine	respiratory flow rate [mL/kg/s] saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2	35161	plethysmography	methacholine	enhanced pause saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2	35168	plethysmography	methacholine	tidal volume [mL] saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2	35181	ventilator	methacholine	airway resistance (H₂0 pressure) [cm/mL/s] saline 1 MCh 3 MCh 10 MCh 30 MCh response index	inbred	29	both	9-12wks	N=9	2010

Mathes1	45209	monitoring system	(none)	nocturnal respiratory exchange ratio (RER) prior to wheel running (VCO2:VO2) [ratio] RER_pre	CC pre w/par	138	m	10-12wks	N=1	2011

McMullan7	61601	monitoring system	(none)	mean oxygen consumption at start of experiment, during day [mL/h] no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7	61604	monitoring system	exercise	mean oxygen consumption after 4 wks of treatment, during day [mL/h] no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7	61607	monitoring system	(none)	mean oxygen consumption at start of experiment, during night [mL/h] no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7	61611	monitoring system	exercise	mean oxygen consumption after 4 wks of treatment, during night [mL/h] no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7	61614	monitoring system	(none)	mean carbon dioxide production at start of experiment, during day [mL/h] no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7	61617	monitoring system	exercise	mean carbon dioxide production after 4 wks of treatment, during day [mL/h] no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7	61621	monitoring system	(none)	mean carbon dioxide production at start of experiment, during night [mL/h] no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7	61624	monitoring system	exercise	mean carbon dioxide production after 4 wks of treatment, during night [mL/h] no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

Schulz1	1630	ventilator	(none)	Fowler dead space volume to total lung capacity [µL/µL] ratio_VDF_TLC	inbred	7	both	12-14wks	N=15	2000

Schulz1	1631	ventilator	(none)	Fowler dead space volume to body weight [µL/g] ratio_VDF_bw	inbred	7	both	12-14wks	N=14	2000

Schulz1	1632	ventilator	(none)	Fowler dead space volume [µL] VDF	inbred	7	both	12-14wks	N=15	2000

Seburn1	9208	monitoring system	(none)	oxygen volume, 3 day test [mL/kg/h] daily light dark	inbred	16	both	7-9wks	N=8	2001

Seburn1	9211	monitoring system	(none)	carbon dioxide volume, 3 day test [mL/kg/h] daily light dark	inbred	14	both	7-9wks	N=8	2001

Ackerman1

15601

ventilator

methacholine

individual pulmonary resistance values, a percentage of baseline for the 100 µg/kg dose [%] RL100

QTL population

f

7-8wks

N=372

2005

Ackerman1

15602

ventilator

methacholine

individual pulmonary resistance, a percentage of baseline for the 330 µg/kg dose [%] RL330

QTL population

f

7-8wks

N=372

2005

Ackerman1

15603

ventilator

methacholine

individual pulmonary resistance, a percentage of baseline for the 1000 µg/kg dose [%] RL1000

QTL population

f

7-8wks

N=372

2005

Ackerman1

15604

ventilator

methacholine

individual pulmonary resistance, a percentage of baseline for the 3300 µg/kg dose [%] RL3300

QTL population

f

7-8wks

N=372

2005

Ackerman1

15605

ventilator

methacholine

effective doses of methacholine required for a 1.50-fold increase in R_L), log transformed [log(n)] logED150

QTL population

f

7-8wks

N=372

2005

Berndt1

34201

ventilator

(none)

airway resistance (naive, untreated, H₂O pressure) [cm/mL/s] airway_res

inbred

36

both

9-12wks

N=9

2010

Berndt1

34210

ventilator

methacholine

airway resistance (H₂O pressure) [cm/mL/s] baseline MCh challenge (mg/mL): 1 3 10 30

inbred

36

both

9-12wks

N=8

2010

Berndt1

34221

ventilator

methacholine

airway resistance (as % of baseline, H₂O pressure) [%] MCh challenge (mg/mL): 1 3 10 30

inbred

36

both

9-12wks

N=8

2010

Berndt2

35101

plethysmography

methacholine

minute ventilation [mL/min] saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

35108

plethysmography

methacholine

breath frequency [n/min] saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

35114

plethysmography

methacholine

inspiratory phase [s] saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

35121

plethysmography

methacholine

expiratory phase [s] saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

35128

plethysmography

methacholine

respiratory cycle [s] saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

35134

plethysmography

methacholine

duty cycle [ratio] saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

35141

plethysmography

methacholine

inspiratory flow rate [mL/kg/s] saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

35148

plethysmography

methacholine

expiratory flow rate [mL/kg/s] saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

35154

plethysmography

methacholine

respiratory flow rate [mL/kg/s] saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

35161

plethysmography

methacholine

enhanced pause saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

35168

plethysmography

methacholine

tidal volume [mL] saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

35181

ventilator

methacholine

airway resistance (H₂0 pressure) [cm/mL/s] saline 1 MCh 3 MCh 10 MCh 30 MCh response index

inbred

29

both

9-12wks

N=9

2010

Mathes1

45209

monitoring system

(none)

nocturnal respiratory exchange ratio (RER) prior to wheel running (VCO2:VO2) [ratio] RER_pre

CC pre w/par

138

m

10-12wks

N=1

2011

McMullan7

61601

monitoring system

(none)

mean oxygen consumption at start of experiment, during day [mL/h] no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

61604

monitoring system

exercise

mean oxygen consumption after 4 wks of treatment, during day [mL/h] no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

61607

monitoring system

(none)

mean oxygen consumption at start of experiment, during night [mL/h] no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

61611

monitoring system

exercise

mean oxygen consumption after 4 wks of treatment, during night [mL/h] no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

61614

monitoring system

(none)

mean carbon dioxide production at start of experiment, during day [mL/h] no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

61617

monitoring system

exercise

mean carbon dioxide production after 4 wks of treatment, during day [mL/h] no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

61621

monitoring system

(none)

mean carbon dioxide production at start of experiment, during night [mL/h] no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

61624

monitoring system

exercise

mean carbon dioxide production after 4 wks of treatment, during night [mL/h] no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

Schulz1

1630

ventilator

(none)

Fowler dead space volume to total lung capacity [µL/µL] ratio_VDF_TLC

inbred

7

both

12-14wks

N=15

2000

Schulz1

1631

ventilator

(none)

Fowler dead space volume to body weight [µL/g] ratio_VDF_bw

inbred

7

both

12-14wks

N=14

2000

Schulz1

1632

ventilator

(none)

Fowler dead space volume [µL] VDF

inbred

7

both

12-14wks

N=15

2000

Seburn1

9208

monitoring system

(none)

oxygen volume, 3 day test [mL/kg/h] daily light dark

inbred

16

both

7-9wks

N=8

2001

Seburn1

9211

monitoring system

(none)

carbon dioxide volume, 3 day test [mL/kg/h] daily light dark

inbred

14

both

7-9wks

N=8

2001

Phenotype measures associated with VT:0002338 'pulmonary ventilation trait'

Phenotype measures associated with
VT:0002338 'pulmonary ventilation trait'