MPD: Phenotype measures mapped to VT:0002338, pulmonary ventilation trait

Sort/ Pick	Data set	Procedure / Protocol	Drug or Challenge	Phenotype Measure / Variable	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Ackerman1:1	Ackerman1	ventilator	methacholine	individual pulmonary resistance values, a percentage of baseline for the 100 µg/kg dose [%] RL100 15601 measure	QTL population		f	7-8wks	N=372	2005

Ackerman1:2	Ackerman1	ventilator	methacholine	individual pulmonary resistance, a percentage of baseline for the 330 µg/kg dose [%] RL330 15602 measure	QTL population		f	7-8wks	N=372	2005

Ackerman1:3	Ackerman1	ventilator	methacholine	individual pulmonary resistance, a percentage of baseline for the 1000 µg/kg dose [%] RL1000 15603 measure	QTL population		f	7-8wks	N=372	2005

Ackerman1:4	Ackerman1	ventilator	methacholine	individual pulmonary resistance, a percentage of baseline for the 3300 µg/kg dose [%] RL3300 15604 measure	QTL population		f	7-8wks	N=372	2005

Ackerman1:5	Ackerman1	ventilator	methacholine	effective doses of methacholine required for a 1.50-fold increase in R_L), log transformed [log(n)] logED150 15605 measure	QTL population		f	7-8wks	N=372	2005

Berndt1:1	Berndt1	ventilator	(none)	airway resistance (naive, untreated, H₂O pressure) [cm/mL/s] airway_res 34201 measure	inbred	36	both	9-12wks	N=9	2010

Berndt1:10	Berndt1	ventilator	methacholine	airway resistance (H₂O pressure) [cm/mL/s] airway_res_series 34210 measure baseline MCh challenge (mg/mL): 1 3 10 30	inbred	36	both	9-12wks	N=8	2010

Berndt1:21	Berndt1	ventilator	methacholine	airway resistance (as % of baseline, H₂O pressure) [%] pct_res 34221 measure MCh challenge (mg/mL): 1 3 10 30	inbred	36	both	9-12wks	N=8	2010

Berndt2:1	Berndt2	plethysmography	methacholine	minute ventilation [mL/min] min_vent 35101 measure saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:8	Berndt2	plethysmography	methacholine	breath frequency [n/min] breath_freq 35108 measure saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:14	Berndt2	plethysmography	methacholine	inspiratory phase [s] inspiratory 35114 measure saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:21	Berndt2	plethysmography	methacholine	expiratory phase [s] expiratory 35121 measure saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:28	Berndt2	plethysmography	methacholine	respiratory cycle [s] tot_respi 35128 measure saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:34	Berndt2	plethysmography	methacholine	duty cycle [ratio] duty_cycle 35134 measure saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:41	Berndt2	plethysmography	methacholine	inspiratory flow rate [mL/kg/s] insp_flow 35141 measure saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:48	Berndt2	plethysmography	methacholine	expiratory flow rate [mL/kg/s] exp_flow 35148 measure saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:54	Berndt2	plethysmography	methacholine	respiratory flow rate [mL/kg/s] resp_flow 35154 measure saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:61	Berndt2	plethysmography	methacholine	enhanced pause penh 35161 measure saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:68	Berndt2	plethysmography	methacholine	tidal volume [mL] tidal_vol 35168 measure saline 5 MCh 10 MCh 20 MCh response index	inbred	29	both	9-12wks	N=8	2010

Berndt2:81	Berndt2	ventilator	methacholine	airway resistance (H₂0 pressure) [cm/mL/s] airway_res 35181 measure saline 1 MCh 3 MCh 10 MCh 30 MCh response index	inbred	29	both	9-12wks	N=9	2010

GMC09:31	GMC09	monitoring system	(none)	mean oxygen consumption, 21 h test, 15 min bins [mL/h] VO2_mean 55831 measure	inbred w/CC8	8	both	12-13wks	N=17	2018

GMC09:32	GMC09	monitoring system	(none)	mean carbon dioxide production, 21 h test, 15 min bins [mL/h] VCO2_mean 55832 measure	inbred w/CC8	8	both	12-13wks	N=17	2018

GMC12:11	GMC12	echocardiography	(none)	respiration rate [n/min] resp_rate 56111 measure	inbred w/CC8	8	both	14-15wks	N=15	2018

GMC19:11	GMC19	ventilator	(none)	residual volume (RV) in the lungs after a maximal exhalation [mL] residual_vol 56811 measure	inbred w/CC8	7	f	21-22wks	N=3	2018

GMC19:12	GMC19	ventilator	(none)	expiratory reserve volume (ERV), FVC minus IC [mL] expiratory_vol 56812 measure	inbred w/CC8	8	f	21-22wks	N=3	2018

GMC19:13	GMC19	ventilator	(none)	forced expiratory volume expired in first 100 ms of fast expiration (FEV100) [mL] forced_expiratory_vol 56813 measure	inbred w/CC8	8	f	21-22wks	N=3	2018

GMC19:14	GMC19	ventilator	(none)	tidal volume (TV) of air into or out of lungs during quiet breathing [mL] tidal_vol 56814 measure	inbred w/CC8	8	f	21-22wks	N=4	2018

GMC19:21	GMC19	ventilator	(none)	total lung capacity (TLC), volume in the lungs at maximal inflation, sum of VC and RV [mL] lung_capacity 56821 measure	inbred w/CC8	7	f	21-22wks	N=3	2018

GMC19:22	GMC19	ventilator	(none)	vital capacity (VC), volume of air breathed out after deepest inhalation [mL] vital_capacity 56822 measure	inbred w/CC8	8	f	21-22wks	N=3	2018

GMC19:23	GMC19	ventilator	(none)	forced vital capacity (FVC), volume expired during fast expiration [mL] forced_capacity 56823 measure	inbred w/CC8	8	f	21-22wks	N=3	2018

GMC19:24	GMC19	ventilator	(none)	inspiratory capacity (IC), volume inspired during slow inspiration [mL] inspiratory_capacity 56824 measure	inbred w/CC8	8	f	21-22wks	N=3	2018

GMC19:25	GMC19	ventilator	(none)	functional residual capacity (FRC), volume in lungs at end-expiratory position [mL] residual_capacity 56825 measure	inbred w/CC8	8	f	21-22wks	N=3	2018

GMC19:31	GMC19	ventilator	(none)	lung compliance (chord compliance) (H₂O pressure) [mL/cm] chord_compliance 56831 measure	inbred w/CC8	8	f	21-22wks	N=3	2018

GMC19:32	GMC19	ventilator	(none)	dynamic compliance (C) of respiratory system with breathing rate of 130/min (H₂O pressure) [mL/cm] dynamic_compliance 56832 measure	inbred w/CC8	8	f	21-22wks	N=4	2018

GMC19:41	GMC19	ventilator	(none)	respiratory system resistance (H₂O pressure) [cm/mL/s] resistance 56841 measure	inbred w/CC8	8	f	21-22wks	N=4	2018

GMC19:42	GMC19	ventilator	(none)	peak expiratory flow (PEF) [mL/s] peak_flow 56842 measure	inbred w/CC8	8	f	21-22wks	N=3	2018

Mathes1:9	Mathes1	monitoring system	(none)	nocturnal respiratory exchange ratio (RER) prior to wheel running (VCO2:VO2) [ratio] RER_pre 45209 measure	CC pre w/par	138	m	10-12wks	N=1	2011

McMullan7:1	McMullan7	monitoring system	(none)	mean oxygen consumption at start of experiment, during day [mL/h] VO2_d_start 61601 measure no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:4	McMullan7	monitoring system	exercise	mean oxygen consumption after 4 wks of treatment, during day [mL/h] VO2_d_end 61604 measure no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:7	McMullan7	monitoring system	(none)	mean oxygen consumption at start of experiment, during night [mL/h] VO2_n_start 61607 measure no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:11	McMullan7	monitoring system	exercise	mean oxygen consumption after 4 wks of treatment, during night [mL/h] VO2_n_end 61611 measure no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:14	McMullan7	monitoring system	(none)	mean carbon dioxide production at start of experiment, during day [mL/h] VCO2_d_start 61614 measure no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:17	McMullan7	monitoring system	exercise	mean carbon dioxide production after 4 wks of treatment, during day [mL/h] VCO2_d_end 61617 measure no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:21	McMullan7	monitoring system	(none)	mean carbon dioxide production at start of experiment, during night [mL/h] VCO2_n_start 61621 measure no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

McMullan7:24	McMullan7	monitoring system	exercise	mean carbon dioxide production after 4 wks of treatment, during night [mL/h] VCO2_n_end 61624 measure no exercise group moderate intensity group high intensity group	CC	4	both	8-10wks	N=8	2018

Schulz1:30	Schulz1	ventilator	(none)	Fowler dead space volume to total lung capacity [µL/µL] ratio_VDF_TLC 1630 measure	inbred	7	both	12-14wks	N=15	2000

Schulz1:31	Schulz1	ventilator	(none)	Fowler dead space volume to body weight [µL/g] ratio_VDF_bw 1631 measure	inbred	7	both	12-14wks	N=14	2000

Schulz1:32	Schulz1	ventilator	(none)	Fowler dead space volume [µL] VDF 1632 measure	inbred	7	both	12-14wks	N=15	2000

Seburn1:8	Seburn1	monitoring system	(none)	oxygen volume, 3 day test [mL/kg/h] VO2 9208 measure daily light dark	inbred	16	both	7-9wks	N=8	2001

Seburn1:11	Seburn1	monitoring system	(none)	carbon dioxide volume, 3 day test [mL/kg/h] VCO2 9211 measure daily light dark	inbred	14	both	7-9wks	N=8	2001

Ackerman1

ventilator

methacholine

individual pulmonary resistance values, a percentage of baseline for the 100 µg/kg dose [%] RL100 15601 measure

QTL population

f

7-8wks

N=372

2005

Ackerman1

ventilator

methacholine

individual pulmonary resistance, a percentage of baseline for the 330 µg/kg dose [%] RL330 15602 measure

QTL population

f

7-8wks

N=372

2005

Ackerman1

ventilator

methacholine

individual pulmonary resistance, a percentage of baseline for the 1000 µg/kg dose [%] RL1000 15603 measure

QTL population

f

7-8wks

N=372

2005

Ackerman1

ventilator

methacholine

individual pulmonary resistance, a percentage of baseline for the 3300 µg/kg dose [%] RL3300 15604 measure

QTL population

f

7-8wks

N=372

2005

Ackerman1

ventilator

methacholine

effective doses of methacholine required for a 1.50-fold increase in R_L), log transformed [log(n)] logED150 15605 measure

QTL population

f

7-8wks

N=372

2005

Berndt1

ventilator

(none)

airway resistance (naive, untreated, H₂O pressure) [cm/mL/s] airway_res 34201 measure

inbred

36

both

9-12wks

N=9

2010

Berndt1

ventilator

methacholine

airway resistance (H₂O pressure) [cm/mL/s] airway_res_series 34210 measure baseline MCh challenge (mg/mL): 1 3 10 30

inbred

36

both

9-12wks

N=8

2010

Berndt1

ventilator

methacholine

airway resistance (as % of baseline, H₂O pressure) [%] pct_res 34221 measure MCh challenge (mg/mL): 1 3 10 30

inbred

36

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

minute ventilation [mL/min] min_vent 35101 measure saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

breath frequency [n/min] breath_freq 35108 measure saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

inspiratory phase [s] inspiratory 35114 measure saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

expiratory phase [s] expiratory 35121 measure saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

respiratory cycle [s] tot_respi 35128 measure saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

duty cycle [ratio] duty_cycle 35134 measure saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

inspiratory flow rate [mL/kg/s] insp_flow 35141 measure saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

expiratory flow rate [mL/kg/s] exp_flow 35148 measure saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

respiratory flow rate [mL/kg/s] resp_flow 35154 measure saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

enhanced pause penh 35161 measure saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

plethysmography

methacholine

tidal volume [mL] tidal_vol 35168 measure saline 5 MCh 10 MCh 20 MCh response index

inbred

29

both

9-12wks

N=8

2010

Berndt2

ventilator

methacholine

airway resistance (H₂0 pressure) [cm/mL/s] airway_res 35181 measure saline 1 MCh 3 MCh 10 MCh 30 MCh response index

inbred

29

both

9-12wks

N=9

2010

GMC09

monitoring system

(none)

mean oxygen consumption, 21 h test, 15 min bins [mL/h] VO2_mean 55831 measure

inbred w/CC8

8

both

12-13wks

N=17

2018

GMC09

monitoring system

(none)

mean carbon dioxide production, 21 h test, 15 min bins [mL/h] VCO2_mean 55832 measure

inbred w/CC8

8

both

12-13wks

N=17

2018

GMC12

echocardiography

(none)

respiration rate [n/min] resp_rate 56111 measure

inbred w/CC8

8

both

14-15wks

N=15

2018

GMC19

ventilator

(none)

residual volume (RV) in the lungs after a maximal exhalation [mL] residual_vol 56811 measure

inbred w/CC8

7

f

21-22wks

N=3

2018

GMC19

ventilator

(none)

expiratory reserve volume (ERV), FVC minus IC [mL] expiratory_vol 56812 measure

inbred w/CC8

8

f

21-22wks

N=3

2018

GMC19

ventilator

(none)

forced expiratory volume expired in first 100 ms of fast expiration (FEV100) [mL] forced_expiratory_vol 56813 measure

inbred w/CC8

8

f

21-22wks

N=3

2018

GMC19

ventilator

(none)

tidal volume (TV) of air into or out of lungs during quiet breathing [mL] tidal_vol 56814 measure

inbred w/CC8

8

f

21-22wks

N=4

2018

GMC19

ventilator

(none)

total lung capacity (TLC), volume in the lungs at maximal inflation, sum of VC and RV [mL] lung_capacity 56821 measure

inbred w/CC8

7

f

21-22wks

N=3

2018

GMC19

ventilator

(none)

vital capacity (VC), volume of air breathed out after deepest inhalation [mL] vital_capacity 56822 measure

inbred w/CC8

8

f

21-22wks

N=3

2018

GMC19

ventilator

(none)

forced vital capacity (FVC), volume expired during fast expiration [mL] forced_capacity 56823 measure

inbred w/CC8

8

f

21-22wks

N=3

2018

GMC19

ventilator

(none)

inspiratory capacity (IC), volume inspired during slow inspiration [mL] inspiratory_capacity 56824 measure

inbred w/CC8

8

f

21-22wks

N=3

2018

GMC19

ventilator

(none)

functional residual capacity (FRC), volume in lungs at end-expiratory position [mL] residual_capacity 56825 measure

inbred w/CC8

8

f

21-22wks

N=3

2018

GMC19

ventilator

(none)

lung compliance (chord compliance) (H₂O pressure) [mL/cm] chord_compliance 56831 measure

inbred w/CC8

8

f

21-22wks

N=3

2018

GMC19

ventilator

(none)

dynamic compliance (C) of respiratory system with breathing rate of 130/min (H₂O pressure) [mL/cm] dynamic_compliance 56832 measure

inbred w/CC8

8

f

21-22wks

N=4

2018

GMC19

ventilator

(none)

respiratory system resistance (H₂O pressure) [cm/mL/s] resistance 56841 measure

inbred w/CC8

8

f

21-22wks

N=4

2018

GMC19

ventilator

(none)

peak expiratory flow (PEF) [mL/s] peak_flow 56842 measure

inbred w/CC8

8

f

21-22wks

N=3

2018

Mathes1

monitoring system

(none)

nocturnal respiratory exchange ratio (RER) prior to wheel running (VCO2:VO2) [ratio] RER_pre 45209 measure

CC pre w/par

138

m

10-12wks

N=1

2011

McMullan7

monitoring system

(none)

mean oxygen consumption at start of experiment, during day [mL/h] VO2_d_start 61601 measure no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

exercise

mean oxygen consumption after 4 wks of treatment, during day [mL/h] VO2_d_end 61604 measure no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

(none)

mean oxygen consumption at start of experiment, during night [mL/h] VO2_n_start 61607 measure no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

exercise

mean oxygen consumption after 4 wks of treatment, during night [mL/h] VO2_n_end 61611 measure no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

(none)

mean carbon dioxide production at start of experiment, during day [mL/h] VCO2_d_start 61614 measure no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

exercise

mean carbon dioxide production after 4 wks of treatment, during day [mL/h] VCO2_d_end 61617 measure no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

(none)

mean carbon dioxide production at start of experiment, during night [mL/h] VCO2_n_start 61621 measure no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

McMullan7

monitoring system

exercise

mean carbon dioxide production after 4 wks of treatment, during night [mL/h] VCO2_n_end 61624 measure no exercise group moderate intensity group high intensity group

CC

4

both

8-10wks

N=8

2018

Schulz1

ventilator

(none)

Fowler dead space volume to total lung capacity [µL/µL] ratio_VDF_TLC 1630 measure

inbred

7

both

12-14wks

N=15

2000

Schulz1

ventilator

(none)

Fowler dead space volume to body weight [µL/g] ratio_VDF_bw 1631 measure

inbred

7

both

12-14wks

N=14

2000

Schulz1

ventilator

(none)

Fowler dead space volume [µL] VDF 1632 measure

inbred

7

both

12-14wks

N=15

2000

Seburn1

monitoring system

(none)

oxygen volume, 3 day test [mL/kg/h] VO2 9208 measure daily light dark

inbred

16

both

7-9wks

N=8

2001

Seburn1

monitoring system

(none)

carbon dioxide volume, 3 day test [mL/kg/h] VCO2 9211 measure daily light dark

inbred

14

both

7-9wks

N=8

2001

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