MPD: Project measures / variables set: Berndt1 pct

Project measures / variables set: Berndt1 pct_res

ID, description, units	MPD:34221 pct_res airway resistance (as % of baseline, H₂O pressure) [%] methacholine study
Measures	• MCh challenge (mg/mL): • 1 • 3 • 10 • 30
Data set, strains	Berndt1 inbred 37 strains sex: both age: 9-12wks
Procedure	ventilator
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0002328 abnormal airway resistance MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt1 - airway resistance (as % of baseline, H₂O pressure)

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	111755.7788	111755.7788	11.8494	0.0007
between strain	28	1190377.7702	42513.4918	4.5077	< 0.0001
between sex:strain	28	508366.7729	18155.9562	1.9251	0.004
between Residuals	327	3084040.8732	9431.3177
within MCh	3	20172894.0722	6724298.0241	1523.6879	< 0.0001
within MCh:sex	3	178220.1093	59406.7031	13.4612	< 0.0001
within MCh:strain	84	1571420.9306	18707.392	4.239	< 0.0001
within MCh:sex:strain	84	572232.9765	6812.2973	1.5436	0.0018
within Residuals	981	4329322.6214	4413.1729

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt1	34221	ventilator	methacholine	airway resistance (as % of baseline, H₂O pressure) [%] MCh challenge 1 mg/mL pct_res_mch1	inbred	37	both	9-12wks
Berndt1	34222	ventilator	methacholine	airway resistance (as % of baseline, H₂O pressure) [%] MCh challenge 3 mg/mL pct_res_mch3	inbred	37	both	9-12wks
Berndt1	34223	ventilator	methacholine	airway resistance (as % of baseline, H₂O pressure) [%] MCh challenge 10 mg/mL pct_res_mch10	inbred	37	both	9-12wks
Berndt1	34224	ventilator	methacholine	airway resistance (as % of baseline, H₂O pressure) [%] MCh challenge 30 mg/mL pct_res_mch30	inbred	37	both	9-12wks