MPD: Project measures / variables set: Berndt2 breath

Project measures / variables set: Berndt2 breath_freq

ID, description, units	MPD:35108 breath_freq breath frequency [n/min] methacholine study
Measures	• saline • 5 MCh • 10 MCh • 20 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	plethysmography
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0001951 abnormal breathing pattern MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

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Berndt2 - breath frequency

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	3214.9198	3214.9198	1.0653	0.3026
between strain	28	2074434.0047	74086.9287	24.5486	< 0.0001
between sex:strain	28	132667.9225	4738.1401	1.57	0.0343
between Residuals	412	1243403.1836	3017.9689
within group	3	22326.8838	7442.2946	5.3752	0.0011
within group:sex	3	4648.4695	1549.4898	1.1191	0.3402
within group:strain	84	804371.4472	9575.8506	6.9162	< 0.0001
within group:sex:strain	84	159844.3874	1902.9094	1.3744	0.0164
within Residuals	1236	1711317.7946	1384.5613

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35108	plethysmography	methacholine	breath frequency [n/min] saline breath_freq_saline	inbred	29	both	9-12wks
Berndt2	35109	plethysmography	methacholine	breath frequency [n/min] 5 MCh breath_freq_mch5	inbred	29	both	9-12wks
Berndt2	35110	plethysmography	methacholine	breath frequency [n/min] 10 MCh breath_freq_mch10	inbred	29	both	9-12wks
Berndt2	35111	plethysmography	methacholine	breath frequency [n/min] 20 MCh breath_freq_mch20	inbred	29	both	9-12wks
Berndt2	35112	plethysmography	methacholine	breath frequency [n/min] response index breath_freq_slope	inbred	29	both	9-12wks	(supplemental / summary measure)