MPD: Project measures / variables set: Berndt2 inspiratory

Project measures / variables set: Berndt2 inspiratory

ID, description, units	MPD:35114 inspiratory inspiratory phase [s] methacholine study
Measures	• saline • 5 MCh • 10 MCh • 20 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	plethysmography
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0001951 abnormal breathing pattern MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt2 - inspiratory phase

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	0.0022	0.0022	5.1708	0.0235
between strain	28	0.2587	0.0092	21.9042	< 0.0001
between sex:strain	28	0.0187	0.0007	1.5796	0.0324
between Residuals	412	0.1738	0.0004
within group	3	0.0715	0.0238	107.1378	< 0.0001
within group:sex	3	0.0009	0.0003	1.4074	0.239
within group:strain	84	0.1352	0.0016	7.2346	< 0.0001
within group:sex:strain	84	0.0241	0.0003	1.2883	0.0452
within Residuals	1236	0.2749	0.0002

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35114	plethysmography	methacholine	inspiratory phase [s] saline inspiratory_saline	inbred	29	both	9-12wks
Berndt2	35115	plethysmography	methacholine	inspiratory phase [s] 5 MCh inspiratory_mch5	inbred	29	both	9-12wks
Berndt2	35116	plethysmography	methacholine	inspiratory phase [s] 10 MCh inspiratory_mch10	inbred	29	both	9-12wks
Berndt2	35117	plethysmography	methacholine	inspiratory phase [s] 20 MCh inspiratory_mch20	inbred	29	both	9-12wks
Berndt2	35118	plethysmography	methacholine	inspiratory phase [s] response index inspiratory_slope	inbred	29	both	9-12wks	(supplemental / summary measure)