MPD: Project measures / variables set: Berndt2 tot

Project measures / variables set: Berndt2 tot_respi

ID, description, units	MPD:35128 tot_respi respiratory cycle [s] methacholine study
Measures	• saline • 5 MCh • 10 MCh • 20 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	plethysmography
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0001951 abnormal breathing pattern MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt2 - respiratory cycle

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	0.0315	0.0315	4.2253	0.0405
between strain	28	4.2388	0.1514	20.3021	< 0.0001
between sex:strain	28	0.3955	0.0141	1.894	0.0045
between Residuals	412	3.0722	0.0075
within group	3	0.0037	0.0012	0.3783	0.7687
within group:sex	3	0.0132	0.0044	1.3435	0.2587
within group:strain	84	2.0953	0.0249	7.6356	< 0.0001
within group:sex:strain	84	0.3495	0.0042	1.2738	0.0529
within Residuals	1236	4.0377	0.0033

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35128	plethysmography	methacholine	respiratory cycle [s] saline tot_respi_saline	inbred	29	both	9-12wks
Berndt2	35129	plethysmography	methacholine	respiratory cycle [s] 5 MCh tot_respi_mch5	inbred	29	both	9-12wks
Berndt2	35130	plethysmography	methacholine	respiratory cycle [s] 10 MCh tot_respi_mch10	inbred	29	both	9-12wks
Berndt2	35131	plethysmography	methacholine	respiratory cycle [s] 20 MCh tot_respi_mch20	inbred	29	both	9-12wks
Berndt2	35132	plethysmography	methacholine	respiratory cycle [s] response index tot_respi_slope	inbred	29	both	9-12wks	(supplemental / summary measure)