MPD: Project measures / variables set: Berndt2 airway

Project measures / variables set: Berndt2 airway_res

ID, description, units	MPD:35181 airway_res airway resistance (H₂0 pressure) [cm/mL/s] methacholine study
Measures	• saline • 1 MCh • 3 MCh • 10 MCh • 30 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	ventilator
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0002328 abnormal airway resistance MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt2 - airway resistance (H₂0 pressure)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	3.5056	3.5056	23.2561	< 0.0001
between strain	25	43.8974	1.7559	11.6484	< 0.0001
between sex:strain	25	16.7194	0.6688	4.4366	< 0.0001
between Residuals	285	42.9612	0.1507
within group	4	332.4687	83.1172	1806.5092	< 0.0001
within group:sex	4	4.8668	1.2167	26.4443	< 0.0001
within group:strain	100	18.9532	0.1895	4.1194	< 0.0001
within group:sex:strain	100	8.2113	0.0821	1.7847	< 0.0001
within Residuals	1140	52.4512	0.046

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35181	ventilator	methacholine	airway resistance (H₂0 pressure) [cm/mL/s] saline airway_res_saline	inbred	29	both	9-12wks
Berndt2	35182	ventilator	methacholine	airway resistance (H₂0 pressure) [cm/mL/s] 1 MCh airway_res_mch1	inbred	29	both	9-12wks
Berndt2	35183	ventilator	methacholine	airway resistance (H₂0 pressure) [cm/mL/s] 3 MCh airway_res_mch3	inbred	29	both	9-12wks
Berndt2	35184	ventilator	methacholine	airway resistance (H₂0 pressure) [cm/mL/s] 10 MCh airway_res_mch10	inbred	29	both	9-12wks
Berndt2	35185	ventilator	methacholine	airway resistance (H₂0 pressure) [cm/mL/s] 30 MCh airway_res_mch30	inbred	29	both	9-12wks
Berndt2	35186	ventilator	methacholine	airway resistance (H₂0 pressure) [cm/mL/s] response index airway_res_slope	inbred	29	both	9-12wks	(supplemental / summary measure)