MPD: Project measures / variables set: Berndt2 tidal

Project measures / variables set: Berndt2 tidal_vol

ID, description, units	MPD:35168 tidal_vol tidal volume [mL] methacholine study
Measures	• saline • 5 MCh • 10 MCh • 20 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	plethysmography
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001942 lung capacity VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0002313 abnormal tidal volume MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt2 - tidal volume

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	0.2814	0.2814	83.4471	< 0.0001
between strain	28	3.7211	0.1329	39.4058	< 0.0001
between sex:strain	28	0.2447	0.0087	2.5909	< 0.0001
between Residuals	412	1.3895	0.0034
within group	3	1.3243	0.4414	333.277	< 0.0001
within group:sex	3	0.0354	0.0118	8.9147	< 0.0001
within group:strain	84	1.2483	0.0149	11.2199	< 0.0001
within group:sex:strain	84	0.1908	0.0023	1.715	0.0001
within Residuals	1236	1.6371	0.0013

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35168	plethysmography	methacholine	tidal volume [mL] saline tidal_vol_saline	inbred	29	both	9-12wks
Berndt2	35169	plethysmography	methacholine	tidal volume [mL] 5 MCh tidal_vol_mch5	inbred	29	both	9-12wks
Berndt2	35170	plethysmography	methacholine	tidal volume [mL] 10 MCh tidal_vol_mch10	inbred	29	both	9-12wks
Berndt2	35171	plethysmography	methacholine	tidal volume [mL] 20 MCh tidal_vol_mch20	inbred	29	both	9-12wks
Berndt2	35172	plethysmography	methacholine	tidal volume [mL] response index tidal_vol_slope	inbred	29	both	9-12wks	(supplemental / summary measure)