Berndt1: Methacholine-induced changes in airway resistance in 37 inbred strains of mice (2010)

Leme AS, Berndt A, Williams LK, Tsaih SW, Szatkiewicz JP, Verdugo R, Paigen B, Shapiro SD. A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Mol Genet Genomics. 2010 Apr;283(4):317-26. Epub 2010 Feb 9.   PubMed 20143096     FullText


       
Berndt1 downloads
• Download Berndt1 project data set     one row per animal, one column per trait
• Download Berndt1 strain means, SD, N, etc.     one row per strain/sex/measure
Participants Annerose Berndt       University of Pittsburgh School of Medicine Pittsburgh, PA
Adriana S Leme       University of Pittsburgh School of Medicine Pittsburgh, PA
Beverly Paigen       The Jackson Laboratory Bar Harbor, ME
Steven D Shapiro       University of Pittsburgh School of Medicine Pittsburgh, PA
ContactAnnerose Berndt     anb128@pitt.edu     Lab web site
AcknowledgementsFunding provided by HL66611, HL83069, CA34196
Project type Phenotype strain survey data set
MPD identifiersBerndt1     MPD:342
Data changelog 1 update/correction.       Initial release date: 07/2010.
Formatted citation
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Summary of procedures that were conducted
• ventilator Airway resistance. Baseline vs. methacholine-challenged (several doses).
Mice: inbred   37 strains   ♀♂   age 9-12wks   1 cohort

Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Berndt1 34201 ventilator (none) airway resistance (naive, untreated, H2O pressure)   [cm/mL/s]  airway_res inbred 36 both 9-12wks N=9
    Berndt1 34210 ventilator methacholine airway resistance (H2O pressure)   [cm/mL/s]     baseline    MCh challenge (mg/mL):    1    3    10    30 inbred 36 both 9-12wks N=9
    Berndt1 34221 ventilator methacholine airway resistance (as % of baseline, H2O pressure)   [%]     MCh challenge (mg/mL):    1    3    10    30 inbred 36 both 9-12wks N=8
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