MPD: Project measures / variables set: Berndt2 exp

Project measures / variables set: Berndt2 exp_flow

ID, description, units	MPD:35148 exp_flow expiratory flow rate [mL/kg/s] methacholine study
Measures	• saline • 5 MCh • 10 MCh • 20 MCh • response index
Data set, strains	Berndt2 inbred 29 strains sex: both age: 9-12wks
Procedure	plethysmography
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0001951 abnormal breathing pattern MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt2 - expiratory flow rate

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	18.43	18.43	42.6076	< 0.0001
between strain	28	319.0012	11.3929	26.3388	< 0.0001
between sex:strain	28	23.7053	0.8466	1.9573	0.0029
between Residuals	412	178.2116	0.4326
within group	3	72.9812	24.3271	153.002	< 0.0001
within group:sex	3	2.131	0.7103	4.4676	0.004
within group:strain	84	119.9305	1.4277	8.9796	< 0.0001
within group:sex:strain	84	21.2429	0.2529	1.5905	0.0008
within Residuals	1236	196.5218	0.159

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt2	35148	plethysmography	methacholine	expiratory flow rate [mL/kg/s] saline exp_flow_saline	inbred	29	both	9-12wks
Berndt2	35149	plethysmography	methacholine	expiratory flow rate [mL/kg/s] 5 MCh exp_flow_mch5	inbred	29	both	9-12wks
Berndt2	35150	plethysmography	methacholine	expiratory flow rate [mL/kg/s] 10 MCh exp_flow_mch10	inbred	29	both	9-12wks
Berndt2	35151	plethysmography	methacholine	expiratory flow rate [mL/kg/s] 20 MCh exp_flow_mch20	inbred	29	both	9-12wks
Berndt2	35152	plethysmography	methacholine	expiratory flow rate [mL/kg/s] response index exp_flow_slope	inbred	29	both	9-12wks	(supplemental / summary measure)