MPD: Project measures / variables set: Berndt1 airway_res

Project measures / variables set: Berndt1 airway_res_series

ID, description, units	MPD:34210 airway_res_series airway resistance (H₂O pressure) [cm/mL/s] methacholine study
Measures	• baseline • MCh challenge (mg/mL): • 1 • 3 • 10 • 30
Data set, strains	Berndt1 inbred 37 strains sex: both age: 9-12wks
Procedure	ventilator
Comparison	repeated measures, baseline then treated multiple doses, same cohort
Ontology mappings	VT:0001943 respiration trait VT:0002338 pulmonary ventilation trait VT:0010487 response to xenobiotic stimulus trait MA:0000415 lung MP:0002328 abnormal airway resistance MP:0002334 abnormal airway responsiveness MP:0008872 abnormal physiological response to xenobiotic

Values Means Δ Means Z-scores

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Berndt1 - airway resistance (H₂O pressure)

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA Summary "within" = Within error "between" = Between Error (Animal ID)

Factor	DF	Sum of squares	Mean sum of squares	F value	p-value (Pr>F)
between sex	1	3.4829	3.4829	22.9954	< 0.0001
between strain	28	46.3255	1.6545	10.9234	< 0.0001
between sex:strain	28	17.0996	0.6107	4.032	< 0.0001
between Residuals	327	49.5283	0.1515
within MCh	4	380.5433	95.1358	2060.3852	< 0.0001
within MCh:sex	4	4.5914	1.1478	24.8593	< 0.0001
within MCh:strain	112	22.1156	0.1975	4.2765	< 0.0001
within MCh:sex:strain	112	9.0184	0.0805	1.7439	< 0.0001
within Residuals	1308	60.3953	0.0462

Q-Q normality assessment based on residuals

INDIVIDUAL MEASURES

Project	ID		Treatment	Measure / Variable Description	Panel	Strains tested	Sex	Age
Berndt1	34210	ventilator	methacholine	airway resistance (H₂O pressure) [cm/mL/s] baseline airway_res_saline	inbred	37	both	9-12wks
Berndt1	34211	ventilator	methacholine	airway resistance (H₂O pressure) [cm/mL/s] MCh challenge 1 mg/mL airway_res_mch1	inbred	37	both	9-12wks
Berndt1	34212	ventilator	methacholine	airway resistance (H₂O pressure) [cm/mL/s] MCh challenge 3 mg/mL airway_res_mch3	inbred	37	both	9-12wks
Berndt1	34213	ventilator	methacholine	airway resistance (H₂O pressure) [cm/mL/s] MCh challenge 10 mg/mL airway_res_mch10	inbred	37	both	9-12wks
Berndt1	34214	ventilator	methacholine	airway resistance (H₂O pressure) [cm/mL/s] MCh challenge 30 mg/mL airway_res_mch30	inbred	37	both	9-12wks