Project measure / variable:   Lake1   QTc

ID, description, units MPD:19945   QTc   rate-corrected QT interval   [ms]  
Data set, strains Lake1   B6.A consomic w/par   23 strains     sex: both     age: 11wks
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  STRAIN COMPARISON PLOT
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Lake1 - rate-corrected QT interval



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested23 strains23 strains
Mean of the strain means46.8   ms 46.5   ms
Median of the strain means46.9   ms 46.3   ms
SD of the strain means± 1.22 ± 1.43
Coefficient of variation (CV)0.0261 0.0307
Min–max range of strain means44.2   –   50.3   ms 44.1   –   50.8   ms
Mean sample size per strain8.0   mice 7.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 10.5651 10.5651 1.9724 0.1612
strain 22 360.4007 16.3818 3.0584 < 0.0001
sex:strain 22 265.4435 12.0656 2.2526 0.0013
Residuals 323 1730.1196 5.3564


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 50.3 6.58   8 2.33 0.131 42.5, 59.1 2.83
A/J m 46.4 4.0   8 1.42 0.0863 42.0, 52.4 -0.05
B6.A-Chr1 f 47.7 3.25   8 1.15 0.0682 41.4, 52.6 0.71
B6.A-Chr1 m 44.1 1.39   8 0.491 0.0315 41.7, 46.0 -1.66
B6.A-Chr10 f 45.9 3.09   9 1.03 0.0674 42.3, 53.2 -0.76
B6.A-Chr10 m 46.2 3.27   8 1.16 0.0707 42.7, 52.3 -0.19
B6.A-Chr11 f 47.6 3.39   8 1.2 0.0712 44.0, 53.1 0.63
B6.A-Chr11 m 46.4 1.43   8 0.504 0.0308 43.8, 48.1 -0.05
B6.A-Chr12 f 46.4 2.55   8 0.901 0.055 43.0, 50.2 -0.36
B6.A-Chr12 m 44.1 1.73   8 0.611 0.0392 40.9, 46.3 -1.66
B6.A-Chr13 f 46.1 1.89   8 0.669 0.041 43.5, 48.5 -0.6
B6.A-Chr13 m 48.8 1.27   8 0.449 0.026 46.6, 50.4 1.63
B6.A-Chr14 f 47.1 2.43   8 0.859 0.0516 43.9, 50.2 0.22
B6.A-Chr14 m 47.0 0.924   8 0.327 0.0196 45.5, 48.0 0.37
B6.A-Chr15 f 46.7 2.0   9 0.667 0.0429 44.4, 49.9 -0.11
B6.A-Chr15 m 47.0 0.905   7 0.342 0.0192 46.0, 48.5 0.37
B6.A-Chr16 f 45.7 2.09   8 0.737 0.0457 42.5, 48.1 -0.93
B6.A-Chr16 m 46.3 1.58   8 0.558 0.0341 43.4, 48.1 -0.12
B6.A-Chr17 f 46.4 1.99   8 0.702 0.0428 43.8, 50.4 -0.36
B6.A-Chr17 m 46.0 1.69   7 0.64 0.0368 43.0, 48.7 -0.33
B6.A-Chr18 f 45.3 1.59   8 0.563 0.0352 43.1, 48.2 -1.25
B6.A-Chr18 m 45.2 1.11   8 0.393 0.0246 43.8, 47.5 -0.89
B6.A-Chr19 f 46.1 1.46   8 0.517 0.0317 44.2, 48.7 -0.6
B6.A-Chr19 m 45.8 2.02   8 0.715 0.0441 43.2, 49.1 -0.47
B6.A-Chr2 f 47.2 1.48   8 0.522 0.0313 44.2, 48.7 0.3
B6.A-Chr2 m 47.3 2.36   8 0.833 0.0499 45.1, 51.4 0.58
B6.A-Chr3 f 44.2 2.77   8 0.979 0.0626 40.1, 48.9 -2.15
B6.A-Chr3 m 45.9 1.75   8 0.619 0.0381 43.1, 47.7 -0.4
B6.A-Chr4 f 48.4 2.45   8 0.864 0.0505 45.0, 51.9 1.28
B6.A-Chr4 m 50.8 3.02   8 1.07 0.0593 46.7, 56.1 3.03
B6.A-Chr5 f 47.1 1.51   8 0.534 0.0321 45.2, 49.2 0.22
B6.A-Chr5 m 47.2 1.8   8 0.638 0.0382 45.1, 50.0 0.51
B6.A-Chr6 f 46.2 2.37   7 0.896 0.0514 42.2, 48.8 -0.52
B6.A-Chr6 m 46.1 2.36   8 0.835 0.0512 43.2, 49.1 -0.26
B6.A-Chr7 f 47.7 2.01   8 0.711 0.0421 44.9, 50.5 0.71
B6.A-Chr7 m 45.2 2.12   8 0.75 0.047 40.5, 47.4 -0.89
B6.A-Chr8 f 47.8 3.23   8 1.14 0.0676 44.9, 54.7 0.79
B6.A-Chr8 m 46.5 1.86   12 0.538 0.04 42.1, 49.6 0.02
B6.A-Chr9 f 46.9 2.0   8 0.708 0.0427 44.0, 49.7 0.05
B6.A-Chr9 m 45.7 1.24   6 0.504 0.0271 43.7, 47.2 -0.54
B6.A-ChrX f 47.2 1.08   8 0.382 0.0229 45.4, 48.7 0.3
B6.A-ChrX m 47.0 1.36   8 0.482 0.029 45.4, 49.1 0.37
B6.A-ChrY f 47.5 1.36   8 0.482 0.0287 45.6, 49.7 0.54
B6.A-ChrY m 46.0 1.81   8 0.639 0.0392 43.1, 47.7 -0.33
C57BL/6J f 45.7 0.9   8 0.318 0.0197 44.6, 47.4 -0.93
C57BL/6J m 47.9 1.49   8 0.528 0.0312 46.2, 50.6 1.0


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 50.2875 0.8183 51.8973 48.6777
A/J m 46.4 0.8183 48.0098 44.7902
B6.A-Chr1 f 47.725 0.8183 49.3348 46.1152
B6.A-Chr1 m 44.05 0.8183 45.6598 42.4402
B6.A-Chr10 f 45.8889 0.7715 47.4066 44.3712
B6.A-Chr10 m 46.2375 0.8183 47.8473 44.6277
B6.A-Chr11 f 47.6 0.8183 49.2098 45.9902
B6.A-Chr11 m 46.3625 0.8183 47.9723 44.7527
B6.A-Chr12 f 46.3875 0.8183 47.9973 44.7777
B6.A-Chr12 m 44.1125 0.8183 45.7223 42.5027
B6.A-Chr13 f 46.125 0.8183 47.7348 44.5152
B6.A-Chr13 m 48.7625 0.8183 50.3723 47.1527
B6.A-Chr14 f 47.075 0.8183 48.6848 45.4652
B6.A-Chr14 m 47.0375 0.8183 48.6473 45.4277
B6.A-Chr15 f 46.6556 0.7715 48.1733 45.1378
B6.A-Chr15 m 47.0429 0.8748 48.7638 45.3219
B6.A-Chr16 f 45.6625 0.8183 47.2723 44.0527
B6.A-Chr16 m 46.2875 0.8183 47.8973 44.6777
B6.A-Chr17 f 46.425 0.8183 48.0348 44.8152
B6.A-Chr17 m 46.0 0.8748 47.7209 44.2791
B6.A-Chr18 f 45.2625 0.8183 46.8723 43.6527
B6.A-Chr18 m 45.25 0.8183 46.8598 43.6402
B6.A-Chr19 f 46.125 0.8183 47.7348 44.5152
B6.A-Chr19 m 45.8375 0.8183 47.4473 44.2277
B6.A-Chr2 f 47.2125 0.8183 48.8223 45.6027
B6.A-Chr2 m 47.2625 0.8183 48.8723 45.6527
B6.A-Chr3 f 44.2375 0.8183 45.8473 42.6277
B6.A-Chr3 m 45.8875 0.8183 47.4973 44.2777
B6.A-Chr4 f 48.3875 0.8183 49.9973 46.7777
B6.A-Chr4 m 50.8375 0.8183 52.4473 49.2277
B6.A-Chr5 f 47.0875 0.8183 48.6973 45.4777
B6.A-Chr5 m 47.25 0.8183 48.8598 45.6402
B6.A-Chr6 f 46.1571 0.8748 47.8781 44.4362
B6.A-Chr6 m 46.1125 0.8183 47.7223 44.5027
B6.A-Chr7 f 47.725 0.8183 49.3348 46.1152
B6.A-Chr7 m 45.15 0.8183 46.7598 43.5402
B6.A-Chr8 f 47.825 0.8183 49.4348 46.2152
B6.A-Chr8 m 46.5417 0.6681 47.8561 45.2273
B6.A-Chr9 f 46.925 0.8183 48.5348 45.3152
B6.A-Chr9 m 45.65 0.9448 47.5088 43.7912
B6.A-ChrX f 47.1875 0.8183 48.7973 45.5777
B6.A-ChrX m 47.05 0.8183 48.6598 45.4402
B6.A-ChrY f 47.5125 0.8183 49.1223 45.9027
B6.A-ChrY m 46.0375 0.8183 47.6473 44.4277
C57BL/6J f 45.6875 0.8183 47.2973 44.0777
C57BL/6J m 47.9375 0.8183 49.5473 46.3277


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 48.3437 0.5786 49.482 47.2055
B6.A-Chr1 both 45.8875 0.5786 47.0258 44.7492
B6.A-Chr10 both 46.0632 0.5623 47.1694 44.957
B6.A-Chr11 both 46.9812 0.5786 48.1195 45.843
B6.A-Chr12 both 45.25 0.5786 46.3883 44.1117
B6.A-Chr13 both 47.4437 0.5786 48.582 46.3055
B6.A-Chr14 both 47.0562 0.5786 48.1945 45.918
B6.A-Chr15 both 46.8492 0.5832 47.9965 45.7019
B6.A-Chr16 both 45.975 0.5786 47.1133 44.8367
B6.A-Chr17 both 46.2125 0.5989 47.3907 45.0343
B6.A-Chr18 both 45.2562 0.5786 46.3945 44.118
B6.A-Chr19 both 45.9812 0.5786 47.1195 44.843
B6.A-Chr2 both 47.2375 0.5786 48.3758 46.0992
B6.A-Chr3 both 45.0625 0.5786 46.2008 43.9242
B6.A-Chr4 both 49.6125 0.5786 50.7508 48.4742
B6.A-Chr5 both 47.1687 0.5786 48.307 46.0305
B6.A-Chr6 both 46.1348 0.5989 47.3131 44.9566
B6.A-Chr7 both 46.4375 0.5786 47.5758 45.2992
B6.A-Chr8 both 47.1833 0.5282 48.2225 46.1442
B6.A-Chr9 both 46.2875 0.625 47.517 45.058
B6.A-ChrX both 47.1187 0.5786 48.257 45.9805
B6.A-ChrY both 46.775 0.5786 47.9133 45.6367
C57BL/6J both 46.8125 0.5786 47.9508 45.6742




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA