Project measure / variable:   Lake1   TBIL

ID, description, units MPD:19931   TBIL   total bilirubin (plasma TBIL)   [mg/dL]  
Data set, strains Lake1   B6.A consomic w/par   23 strains     sex: both     age: 8wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Lake1 - total bilirubin (plasma TBIL)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested23 strains23 strains
Mean of the strain means0.446   mg/dL 0.481   mg/dL
Median of the strain means0.400   mg/dL 0.443   mg/dL
SD of the strain means± 0.146 ± 0.105
Coefficient of variation (CV)0.327 0.219
Min–max range of strain means0.337   –   0.960   mg/dL 0.343   –   0.760   mg/dL
Mean sample size per strain7.0   mice 7.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.1981 0.1981 4.4268 0.0363
strain 22 1.766 0.0803 1.7941 0.0173
sex:strain 22 2.5703 0.1168 2.6113 0.0002
Residuals 283 12.6617 0.0447


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
A/J f 0.525 0.104   8 0.0366 0.197 0.4, 0.7 0.54
A/J m 0.487 0.0835   8 0.0295 0.171 0.4, 0.6 0.06
B6.A-Chr1 f 0.425 0.05   4 0.025 0.118 0.4, 0.5 -0.14
B6.A-Chr1 m 0.5 0.0816   7 0.0309 0.163 0.4, 0.6 0.18
B6.A-Chr10 f 0.343 0.0787   7 0.0297 0.229 0.2, 0.4 -0.71
B6.A-Chr10 m 0.614 0.485   7 0.183 0.789 0.3, 1.7 1.27
B6.A-Chr11 f 0.35 0.0926   8 0.0327 0.265 0.2, 0.5 -0.66
B6.A-Chr11 m 0.383 0.117   6 0.0477 0.305 0.3, 0.6 -0.93
B6.A-Chr12 f 0.375 0.0707   8 0.025 0.189 0.3, 0.5 -0.49
B6.A-Chr12 m 0.362 0.0744   8 0.0263 0.205 0.3, 0.5 -1.13
B6.A-Chr13 f 0.35 0.105   6 0.0428 0.3 0.2, 0.5 -0.66
B6.A-Chr13 m 0.443 0.151   7 0.0571 0.341 0.2, 0.7 -0.36
B6.A-Chr14 f 0.337 0.106   8 0.0375 0.314 0.2, 0.5 -0.75
B6.A-Chr14 m 0.425 0.0463   8 0.0164 0.109 0.4, 0.5 -0.53
B6.A-Chr15 f 0.75 0.164   6 0.0671 0.219 0.5, 1.0 2.08
B6.A-Chr15 m 0.575 0.167   8 0.059 0.29 0.3, 0.8 0.9
B6.A-Chr16 f 0.375 0.167   8 0.059 0.445 -0.49
B6.A-Chr16 m 0.417 0.0753   6 0.0307 0.181 0.3, 0.5 -0.61
B6.A-Chr17 f 0.96 1.15   5 0.514 1.2 0.2, 3.0 3.52
B6.A-Chr17 m 0.387 0.125   8 0.0441 0.322 0.2, 0.6 -0.89
B6.A-Chr18 f 0.5 0.177   8 0.0627 0.355 0.3, 0.8 0.37
B6.A-Chr18 m 0.425 0.0886   8 0.0313 0.209 0.3, 0.5 -0.53
B6.A-Chr19 f 0.429 0.0756   7 0.0286 0.176 0.3, 0.5 -0.12
B6.A-Chr19 m 0.443 0.0787   7 0.0297 0.178 0.3, 0.5 -0.36
B6.A-Chr2 f 0.362 0.0744   8 0.0263 0.205 0.3, 0.5 -0.58
B6.A-Chr2 m 0.76 0.358   5 0.16 0.471 0.6, 1.4 2.66
B6.A-Chr3 f 0.388 0.0991   8 0.035 0.256 0.3, 0.6 -0.4
B6.A-Chr3 m 0.637 0.262   8 0.0925 0.41 0.1, 1.0 1.49
B6.A-Chr4 f 0.517 0.194   6 0.0792 0.376 0.4, 0.9 0.49
B6.A-Chr4 m 0.486 0.09   7 0.034 0.185 0.4, 0.6 0.05
B6.A-Chr5 f 0.337 0.0916   8 0.0324 0.271 0.2, 0.5 -0.75
B6.A-Chr5 m 0.438 0.0744   8 0.0263 0.17 0.4, 0.6 -0.41
B6.A-Chr6 f 0.414 0.146   7 0.0553 0.353 0.3, 0.7 -0.22
B6.A-Chr6 m 0.562 0.185   8 0.0653 0.328 0.2, 0.7 0.77
B6.A-Chr7 f 0.4 0.115   7 0.0436 0.289 0.2, 0.6 -0.31
B6.A-Chr7 m 0.343 0.0976   7 0.0369 0.285 0.2, 0.5 -1.31
B6.A-Chr8 f 0.35 0.0926   8 0.0327 0.265 0.2, 0.5 -0.66
B6.A-Chr8 m 0.618 0.4   11 0.12 0.646 0.4, 1.8 1.31
B6.A-Chr9 f 0.45 0.152   6 0.0619 0.337 0.3, 0.7 0.03
B6.A-Chr9 m 0.5 0.107   8 0.0378 0.214 0.4, 0.7 0.18
B6.A-ChrX f 0.357 0.127   7 0.0481 0.356 0.2, 0.6 -0.61
B6.A-ChrX m 0.35 0.105   6 0.0428 0.3 0.2, 0.5 -1.24
B6.A-ChrY f 0.463 0.141   8 0.0498 0.304 0.2, 0.6 0.12
B6.A-ChrY m 0.417 0.117   6 0.0477 0.281 0.2, 0.5 -0.61
C57BL/6J f 0.5 0.163   4 0.0816 0.327 0.3, 0.7 0.37
C57BL/6J m 0.486 0.069   7 0.0261 0.142 0.4, 0.6 0.05


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
A/J f 0.525 0.0748 0.6722 0.3778
A/J m 0.4875 0.0748 0.6347 0.3403
B6.A-Chr1 f 0.425 0.1058 0.6332 0.2168
B6.A-Chr1 m 0.5 0.0799 0.6574 0.3426
B6.A-Chr10 f 0.3429 0.0799 0.5002 0.1855
B6.A-Chr10 m 0.6143 0.0799 0.7717 0.4569
B6.A-Chr11 f 0.35 0.0748 0.4972 0.2028
B6.A-Chr11 m 0.3833 0.0864 0.5533 0.2134
B6.A-Chr12 f 0.375 0.0748 0.5222 0.2278
B6.A-Chr12 m 0.3625 0.0748 0.5097 0.2153
B6.A-Chr13 f 0.35 0.0864 0.52 0.18
B6.A-Chr13 m 0.4429 0.0799 0.6002 0.2855
B6.A-Chr14 f 0.3375 0.0748 0.4847 0.1903
B6.A-Chr14 m 0.425 0.0748 0.5722 0.2778
B6.A-Chr15 f 0.75 0.0864 0.92 0.58
B6.A-Chr15 m 0.575 0.0748 0.7222 0.4278
B6.A-Chr16 f 0.375 0.0748 0.5222 0.2278
B6.A-Chr16 m 0.4167 0.0864 0.5866 0.2467
B6.A-Chr17 f 0.96 0.0946 1.1462 0.7738
B6.A-Chr17 m 0.3875 0.0748 0.5347 0.2403
B6.A-Chr18 f 0.5 0.0748 0.6472 0.3528
B6.A-Chr18 m 0.425 0.0748 0.5722 0.2778
B6.A-Chr19 f 0.4286 0.0799 0.5859 0.2712
B6.A-Chr19 m 0.4429 0.0799 0.6002 0.2855
B6.A-Chr2 f 0.3625 0.0748 0.5097 0.2153
B6.A-Chr2 m 0.76 0.0946 0.9462 0.5738
B6.A-Chr3 f 0.3875 0.0748 0.5347 0.2403
B6.A-Chr3 m 0.6375 0.0748 0.7847 0.4903
B6.A-Chr4 f 0.5167 0.0864 0.6866 0.3467
B6.A-Chr4 m 0.4857 0.0799 0.6431 0.3283
B6.A-Chr5 f 0.3375 0.0748 0.4847 0.1903
B6.A-Chr5 m 0.4375 0.0748 0.5847 0.2903
B6.A-Chr6 f 0.4143 0.0799 0.5717 0.2569
B6.A-Chr6 m 0.5625 0.0748 0.7097 0.4153
B6.A-Chr7 f 0.4 0.0799 0.5574 0.2426
B6.A-Chr7 m 0.3429 0.0799 0.5002 0.1855
B6.A-Chr8 f 0.35 0.0748 0.4972 0.2028
B6.A-Chr8 m 0.6182 0.0638 0.7437 0.4926
B6.A-Chr9 f 0.45 0.0864 0.62 0.28
B6.A-Chr9 m 0.5 0.0748 0.6472 0.3528
B6.A-ChrX f 0.3571 0.0799 0.5145 0.1998
B6.A-ChrX m 0.35 0.0864 0.52 0.18
B6.A-ChrY f 0.4625 0.0748 0.6097 0.3153
B6.A-ChrY m 0.4167 0.0864 0.5866 0.2467
C57BL/6J f 0.5 0.1058 0.7082 0.2918
C57BL/6J m 0.4857 0.0799 0.6431 0.3283


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
A/J both 0.5062 0.0529 0.6103 0.4022
B6.A-Chr1 both 0.4625 0.0663 0.593 0.332
B6.A-Chr10 both 0.4786 0.0565 0.5898 0.3673
B6.A-Chr11 both 0.3667 0.0571 0.4791 0.2542
B6.A-Chr12 both 0.3688 0.0529 0.4728 0.2647
B6.A-Chr13 both 0.3964 0.0588 0.5122 0.2806
B6.A-Chr14 both 0.3812 0.0529 0.4853 0.2772
B6.A-Chr15 both 0.6625 0.0571 0.7749 0.5501
B6.A-Chr16 both 0.3958 0.0571 0.5083 0.2834
B6.A-Chr17 both 0.6738 0.0603 0.7924 0.5551
B6.A-Chr18 both 0.4625 0.0529 0.5666 0.3584
B6.A-Chr19 both 0.4357 0.0565 0.547 0.3244
B6.A-Chr2 both 0.5612 0.0603 0.6799 0.4426
B6.A-Chr3 both 0.5125 0.0529 0.6166 0.4084
B6.A-Chr4 both 0.5012 0.0588 0.617 0.3854
B6.A-Chr5 both 0.3875 0.0529 0.4916 0.2834
B6.A-Chr6 both 0.4884 0.0547 0.5961 0.3807
B6.A-Chr7 both 0.3714 0.0565 0.4827 0.2602
B6.A-Chr8 both 0.4841 0.0491 0.5808 0.3874
B6.A-Chr9 both 0.475 0.0571 0.5874 0.3626
B6.A-ChrX both 0.3536 0.0588 0.4694 0.2378
B6.A-ChrY both 0.4396 0.0571 0.552 0.3272
C57BL/6J both 0.4929 0.0663 0.6233 0.3624




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA