MPD: Measures involving ethanol

Sort/ Pick	Data set	Procedure / Protocol	Drug or Challenge	Phenotype Measure	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Bennett3:1	Bennett3	alcohol quantification	ethanol	blood ethanol concentration (BEC) [mg/mL] BEC 37501 first loss of balance (ataxia) first regain of balance second regain of balance	ILSXISS w/par	72	both	8-14wks	N=5	2007

Bennett3:4	Bennett3	alcohol quantification	ethanol	acute functional tolerance to ethanol (BEC2-BEC1) [mg/mL] AFT1 37504	ILSXISS w/par	72	both	8-14wks	N=5	2007

Bennett3:5	Bennett3	alcohol quantification	ethanol	acute functional tolerance to ethanol (BEC2-BEC0) [mg/mL] AFT2 37505	ILSXISS w/par	72	both	8-14wks	N=5	2007

Chesler6:4	Chesler6	rotarod	ethanol	latency difference, two trial post alcohol average minus pre trial latency to fall off rotarod [s] Rotarod_atax 27104	QTL population		both	9-34wks	N=186	2012

Chesler6:5	Chesler6	body temperature	ethanol	post alcohol minus pre alcohol body temperature [° C] Hypotherm 27105	QTL population		both	9-34wks	N=186	2012

Chesler6:6	Chesler6	behavior observation	ethanol	alcohol induced loss of righting reflex, latency to return of reflex [s] LORR 27106	QTL population		both	9-34wks	N=186	2012

Chesler6:7	Chesler6	alcohol quantification	ethanol	blood ethanol concentration at return of righting reflex [mg/mL] LORR_BEC 27107	QTL population		both	9-34wks	N=186	2012

Chesler6:9	Chesler6	rotarod	ethanol	latency to fall, first alcohol trial [s] RotaTest1 27109	QTL population		both	9-34wks	N=186	2012

Crabbe1:3	Crabbe1	balance beam	ethanol	missteps crossing 12.7mm wide balance beam [n] bal12 15403 dose (g/kg) control 1.0 1.2 1.4	inbred	7	both	8-16wks	N=3	2003

Crabbe1:4	Crabbe1	balance beam	ethanol	missteps crossing 15.8mm wide balance beam [n] bal15 15404 dose (g/kg): control 1.0 1.2 1.4	inbred	8	both	8-16wks	N=3	2003

Crabbe1:5	Crabbe1	balance beam	ethanol	missteps crossing 19.0 mm wide balance beam [n] bal19 15405 dose (g/kg) control 1.0 1.2 1.4	inbred	8	both	8-16wks	N=3	2003

Crabbe1:6	Crabbe1	grid test	ethanol	grid habituation, distance traveled [cm] grid_dist 15406 dose (g/kg): control 1.5 2.0 2.5	inbred	8	both	8-16wks	N=12	2003

Crabbe1:7	Crabbe1	grid test	ethanol	grid habituation, missteps per cm [n/cm] grid_ataxia 15407 dose (g/kg): control 1.5 2.0 2.5	inbred	8	both	8-16wks	N=12	2003

Crabbe3:10	Crabbe3	rotarod	ethanol	latency to fall, fixed speed 3 rpm rotarod [s] FS_3rpm_EtOH 15810 dose (g/kg): 1 2 3	inbred	9	both	9-17wks	N=4	2003

Crabbe3:15	Crabbe3	rotarod	ethanol	latency to fall, fixed speed 6 rpm rotarod [s] FS_6rpm_EtOH 15815 dose (g/kg) 1 2 3	inbred	9	both	9-17wks	N=3	2003

Crabbe3:20	Crabbe3	rotarod	ethanol	latency to fall, fixed speed 10 rpm rotarod [s] FS_10rpm_EtOH 15820 dose (g/kg): 1 2 3	inbred	7	both	9-17wks	N=3	2003

Crabbe3:40	Crabbe3	rotarod	ethanol	latency to-fall, accelerating rotarod, test day 1 20 rpm/min (ARR1) [s] ARR1_20rpm 15840 baseline ethanol difference	inbred	8	both	9-17wks	N=6	2003

Crabbe3:45	Crabbe3	rotarod	ethanol	latency to-fall, accelerating rotarod, test day 2 30 rpm/min (ARR1) [s] ARR1_30rpm 15845 baseline ethanol difference	inbred	8	both	9-17wks	N=6	2003

Crabbe3:55	Crabbe3	rotarod	ethanol	latency to fall, accelerating rotarod, 20 rpm/min (ARR2) [s] ARR2_20rpm 15855 baseline ethanol	inbred	21	both	9-17wks	N=9	2003

Crabbe3:57	Crabbe3	rotarod	ethanol	average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection trials minus pre-injection trials (ETPOST - ETBASE) [s] ARR2_chg_20rpm 15857	inbred	21	both	9-17wks	N=9	2003

Crabbe4:1	Crabbe4	vertical wire mesh	ethanol	latency to fall from a vertical wire mesh grid 30 min post-injection [s] latency_screen30 19101	inbred	8	both	9-10wks	N=5	2003

Crabbe4:2	Crabbe4	dowel balance test	ethanol	latency to fall, 0 min post-injection [s] latency_dowel0 19102 9.5mm 15.8mm	inbred	8	both	12-16wks	N=4	2003

Crabbe4:3	Crabbe4	dowel balance test	ethanol	latency to fall, 30 min post-injection [s] latency_dowel30 19103 9.5mm 15.8mm	inbred	8	both	12-16wks	N=4	2003

Crabbe4:6	Crabbe4	grip strength	ethanol	grip strength test: peak force applied [g] grip 19106 baseline 30min after ethanol	inbred	21	both	7-12wks	N=6	2003

Crabbe4:8	Crabbe4	grip strength	ethanol	change in peak force applied (T0-T30) post-injection, grip strength test [g] gripEtOHeffect 19108	inbred	21	both	7-12wks	N=6	2003

Crabbe4:9	Crabbe4	grip strength	ethanol	percent change in average latency to fall post-injection, grip strength test [%] pct_gripchange 19109	inbred	21	both	7-12wks	N=6	2003

Crabbe4:11	Crabbe4	alcohol quantification	ethanol	blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test [mg/mL] BEC_dowel15_8 19111	inbred	8	both	12-16wks	N=3	2003

Crabbe4:12	Crabbe4	alcohol quantification	ethanol	blood ethanol concentration [mg/mL] BEC 19112 time after ethanol: 30min 60min 105min 150min	inbred	21	both	7-12wks	N=6	2003

Crabbe5:1	Crabbe5	parallel rod floor test	ethanol	distance traveled, 1.6mm rod, 6mm space [cm] dist 19601 day1 control day2 control day3 ethanol	inbred	8	both	8-10wks	N=6	2005

Crabbe5:3	Crabbe5	parallel rod floor test	ethanol	motor incoordination, errors over distance traveled, 1.6mm rod, 6mm space [n/cm] err 19603 day1 control day2 control day3 ethanol	inbred	8	both	7-14wks	N=6	2005

Metten1:1	Metten1	open field test	ethanol	line crossings, 2.75 g/kg i.p. [n] line_doseA 16501 pre-injection 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1:2	Metten1	open field test	ethanol	line crossings, 3.0 g/kg i.p. [n] line_doseB 16502 pre-injection 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1:9	Metten1	behavior observation	ethanol	hindlimb splay, 2.75 g/kg i.p. [score] splay_doseA 16509 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1:11	Metten1	behavior observation	ethanol	hindlimb splay, 3.0 g/kg i.p. [score] splay_doseB 16511 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1:13	Metten1	behavior observation	ethanol	erratic gait, 2.75 g/kg i.p. [score] wobble_doseA 16513 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1:15	Metten1	behavior observation	ethanol	erratic gait, 3.0 g/kg i.p. [score] wobble_doseB 16515 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten2:3	Metten2	behavior observation	ethanol	peak handling-induced convulsion (HIC) score [score] peak 19503 control ethanol ethanol normalized to controls	inbred	15	m	8-15wks	N=9	2005

Metten2:6	Metten2	behavior observation	ethanol	latency to first handling-induced convulsions score used to calculate peak ethanol [h] peak_latency 19506	inbred	15	m	8-15wks	N=11	2005

Metten2:7	Metten2	behavior observation	ethanol	withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores [AUC] withdrawal_EtOH 19507	inbred	15	m	8-15wks	N=20	2005

Metten2:8	Metten2	behavior observation	ethanol	withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores normalized to controls [AUC] withdrawal_EtOHadj 19508	inbred	14	m	8-15wks	N=11	2005

Bennett3

ethanol

blood ethanol concentration (BEC) [mg/mL] BEC 37501 first loss of balance (ataxia) first regain of balance second regain of balance

ILSXISS w/par

72

both

8-14wks

N=5

2007

Bennett3

alcohol quantification

ethanol

acute functional tolerance to ethanol (BEC2-BEC1) [mg/mL] AFT1 37504

ILSXISS w/par

72

both

8-14wks

N=5

2007

Bennett3

alcohol quantification

ethanol

acute functional tolerance to ethanol (BEC2-BEC0) [mg/mL] AFT2 37505

ILSXISS w/par

72

both

8-14wks

N=5

2007

Chesler6

rotarod

ethanol

latency difference, two trial post alcohol average minus pre trial latency to fall off rotarod [s] Rotarod_atax 27104

QTL population

both

9-34wks

N=186

2012

Chesler6

body temperature

ethanol

post alcohol minus pre alcohol body temperature [° C] Hypotherm 27105

QTL population

both

9-34wks

N=186

2012

Chesler6

behavior observation

ethanol

alcohol induced loss of righting reflex, latency to return of reflex [s] LORR 27106

QTL population

both

9-34wks

N=186

2012

Chesler6

alcohol quantification

ethanol

blood ethanol concentration at return of righting reflex [mg/mL] LORR_BEC 27107

QTL population

both

9-34wks

N=186

2012

Chesler6

rotarod

ethanol

latency to fall, first alcohol trial [s] RotaTest1 27109

QTL population

both

9-34wks

N=186

2012

Crabbe1

balance beam

ethanol

missteps crossing 12.7mm wide balance beam [n] bal12 15403 dose (g/kg) control 1.0 1.2 1.4

inbred

7

both

8-16wks

N=3

2003

Crabbe1

balance beam

ethanol

missteps crossing 15.8mm wide balance beam [n] bal15 15404 dose (g/kg): control 1.0 1.2 1.4

inbred

8

both

8-16wks

N=3

2003

Crabbe1

balance beam

ethanol

missteps crossing 19.0 mm wide balance beam [n] bal19 15405 dose (g/kg) control 1.0 1.2 1.4

inbred

8

both

8-16wks

N=3

2003

Crabbe1

grid test

ethanol

grid habituation, distance traveled [cm] grid_dist 15406 dose (g/kg): control 1.5 2.0 2.5

inbred

8

both

8-16wks

N=12

2003

Crabbe1

grid test

ethanol

grid habituation, missteps per cm [n/cm] grid_ataxia 15407 dose (g/kg): control 1.5 2.0 2.5

inbred

8

both

8-16wks

N=12

2003

Crabbe3

rotarod

ethanol

latency to fall, fixed speed 3 rpm rotarod [s] FS_3rpm_EtOH 15810 dose (g/kg): 1 2 3

inbred

9

both

9-17wks

N=4

2003

Crabbe3

rotarod

ethanol

latency to fall, fixed speed 6 rpm rotarod [s] FS_6rpm_EtOH 15815 dose (g/kg) 1 2 3

inbred

9

both

9-17wks

N=3

2003

Crabbe3

rotarod

ethanol

latency to fall, fixed speed 10 rpm rotarod [s] FS_10rpm_EtOH 15820 dose (g/kg): 1 2 3

inbred

7

both

9-17wks

N=3

2003

Crabbe3

rotarod

ethanol

latency to-fall, accelerating rotarod, test day 1 20 rpm/min (ARR1) [s] ARR1_20rpm 15840 baseline ethanol difference

inbred

8

both

9-17wks

N=6

2003

Crabbe3

rotarod

ethanol

latency to-fall, accelerating rotarod, test day 2 30 rpm/min (ARR1) [s] ARR1_30rpm 15845 baseline ethanol difference

inbred

8

both

9-17wks

N=6

2003

Crabbe3

rotarod

ethanol

latency to fall, accelerating rotarod, 20 rpm/min (ARR2) [s] ARR2_20rpm 15855 baseline ethanol

inbred

21

both

9-17wks

N=9

2003

Crabbe3

rotarod

ethanol

average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection trials minus pre-injection trials (ETPOST - ETBASE) [s] ARR2_chg_20rpm 15857

inbred

21

both

9-17wks

N=9

2003

Crabbe4

vertical wire mesh

ethanol

latency to fall from a vertical wire mesh grid 30 min post-injection [s] latency_screen30 19101

inbred

8

both

9-10wks

N=5

2003

Crabbe4

dowel balance test

ethanol

latency to fall, 0 min post-injection [s] latency_dowel0 19102 9.5mm 15.8mm

inbred

8

both

12-16wks

N=4

2003

Crabbe4

dowel balance test

ethanol

latency to fall, 30 min post-injection [s] latency_dowel30 19103 9.5mm 15.8mm

inbred

8

both

12-16wks

N=4

2003

Crabbe4

grip strength

ethanol

grip strength test: peak force applied [g] grip 19106 baseline 30min after ethanol

inbred

21

both

7-12wks

N=6

2003

Crabbe4

grip strength

ethanol

change in peak force applied (T0-T30) post-injection, grip strength test [g] gripEtOHeffect 19108

inbred

21

both

7-12wks

N=6

2003

Crabbe4

grip strength

ethanol

percent change in average latency to fall post-injection, grip strength test [%] pct_gripchange 19109

inbred

21

both

7-12wks

N=6

2003

Crabbe4

alcohol quantification

ethanol

blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test [mg/mL] BEC_dowel15_8 19111

inbred

8

both

12-16wks

N=3

2003

Crabbe4

alcohol quantification

ethanol

blood ethanol concentration [mg/mL] BEC 19112 time after ethanol: 30min 60min 105min 150min

inbred

21

both

7-12wks

N=6

2003

Crabbe5

parallel rod floor test

ethanol

distance traveled, 1.6mm rod, 6mm space [cm] dist 19601 day1 control day2 control day3 ethanol

inbred

8

both

8-10wks

N=6

2005

Crabbe5

parallel rod floor test

ethanol

motor incoordination, errors over distance traveled, 1.6mm rod, 6mm space [n/cm] err 19603 day1 control day2 control day3 ethanol

inbred

8

both

7-14wks

N=6

2005

Metten1

open field test

ethanol

line crossings, 2.75 g/kg i.p. [n] line_doseA 16501 pre-injection 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

open field test

ethanol

line crossings, 3.0 g/kg i.p. [n] line_doseB 16502 pre-injection 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

behavior observation

ethanol

hindlimb splay, 2.75 g/kg i.p. [score] splay_doseA 16509 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

behavior observation

ethanol

hindlimb splay, 3.0 g/kg i.p. [score] splay_doseB 16511 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

behavior observation

ethanol

erratic gait, 2.75 g/kg i.p. [score] wobble_doseA 16513 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

behavior observation

ethanol

erratic gait, 3.0 g/kg i.p. [score] wobble_doseB 16515 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten2

behavior observation

ethanol

peak handling-induced convulsion (HIC) score [score] peak 19503 control ethanol ethanol normalized to controls

inbred

15

m

8-15wks

N=9

2005

Metten2

behavior observation

ethanol

latency to first handling-induced convulsions score used to calculate peak ethanol [h] peak_latency 19506

inbred

15

m

8-15wks

N=11

2005

Metten2

behavior observation

ethanol

withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores [AUC] withdrawal_EtOH 19507

inbred

15

m

8-15wks

N=20

2005

Metten2

behavior observation

ethanol

withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores normalized to controls [AUC] withdrawal_EtOHadj 19508

inbred

14

m

8-15wks

N=11

2005