MPD: Measures involving ethanol

Data set	MPD ID	Procedure / Protocol	Drug or Challenge	Phenotype Measure	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Bennett3	37501	alcohol quantification	ethanol	blood ethanol concentration (BEC) [mg/mL] first loss of balance (ataxia) first regain of balance second regain of balance	ILSXISS w/par	72	both	8-14wks	N=5	2007

Bennett3	37504	alcohol quantification	ethanol	acute functional tolerance to ethanol (BEC2-BEC1) [mg/mL] AFT1	ILSXISS w/par	72	both	8-14wks	N=5	2007

Bennett3	37505	alcohol quantification	ethanol	acute functional tolerance to ethanol (BEC2-BEC0) [mg/mL] AFT2	ILSXISS w/par	72	both	8-14wks	N=5	2007

Chesler6	27104	rotarod	ethanol	latency difference, two trial post alcohol average minus pre trial latency to fall off rotarod [s] Rotarod_atax	QTL population		both	9-34wks	N=186	2012

Chesler6	27105	body temperature	ethanol	post alcohol minus pre alcohol body temperature [° C] Hypotherm	QTL population		both	9-34wks	N=186	2012

Chesler6	27106	behavior observation	ethanol	alcohol induced loss of righting reflex, latency to return of reflex [s] LORR	QTL population		both	9-34wks	N=186	2012

Chesler6	27107	alcohol quantification	ethanol	blood ethanol concentration at return of righting reflex [mg/mL] LORR_BEC	QTL population		both	9-34wks	N=186	2012

Chesler6	27109	rotarod	ethanol	latency to fall, first alcohol trial [s] RotaTest1	QTL population		both	9-34wks	N=186	2012

Crabbe1	15403	balance beam	ethanol	missteps crossing 12.7mm wide balance beam [n] dose (g/kg) control 1.0 1.2 1.4	inbred	7	both	8-16wks	N=3	2003

Crabbe1	15404	balance beam	ethanol	missteps crossing 15.8mm wide balance beam [n] dose (g/kg): control 1.0 1.2 1.4	inbred	8	both	8-16wks	N=3	2003

Crabbe1	15405	balance beam	ethanol	missteps crossing 19.0 mm wide balance beam [n] dose (g/kg) control 1.0 1.2 1.4	inbred	8	both	8-16wks	N=3	2003

Crabbe1	15406	grid test	ethanol	grid habituation, distance traveled [cm] dose (g/kg): control 1.5 2.0 2.5	inbred	8	both	8-16wks	N=12	2003

Crabbe1	15407	grid test	ethanol	grid habituation, missteps per cm [n/cm] dose (g/kg): control 1.5 2.0 2.5	inbred	8	both	8-16wks	N=12	2003

Crabbe3	15810	rotarod	ethanol	latency to fall, fixed speed 3 rpm rotarod [s] dose (g/kg): 1 2 3	inbred	9	both	9-17wks	N=4	2003

Crabbe3	15815	rotarod	ethanol	latency to fall, fixed speed 6 rpm rotarod [s] dose (g/kg) 1 2 3	inbred	9	both	9-17wks	N=3	2003

Crabbe3	15820	rotarod	ethanol	latency to fall, fixed speed 10 rpm rotarod [s] dose (g/kg): 1 2 3	inbred	7	both	9-17wks	N=3	2003

Crabbe3	15840	rotarod	ethanol	latency to-fall, accelerating rotarod, test day 1 20 rpm/min (ARR1) [s] baseline ethanol difference	inbred	8	both	9-17wks	N=6	2003

Crabbe3	15845	rotarod	ethanol	latency to-fall, accelerating rotarod, test day 2 30 rpm/min (ARR1) [s] baseline ethanol difference	inbred	8	both	9-17wks	N=6	2003

Crabbe3	15855	rotarod	ethanol	latency to fall, accelerating rotarod, 20 rpm/min (ARR2) [s] baseline ethanol	inbred	21	both	9-17wks	N=9	2003

Crabbe3	15857	rotarod	ethanol	average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection trials minus pre-injection trials (ETPOST - ETBASE) [s] ARR2_chg_20rpm	inbred	21	both	9-17wks	N=9	2003

Crabbe4	19101	vertical wire mesh	ethanol	latency to fall from a vertical wire mesh grid 30 min post-injection [s] latency_screen30	inbred	8	both	9-10wks	N=5	2003

Crabbe4	19102	dowel balance test	ethanol	latency to fall, 0 min post-injection [s] 9.5mm 15.8mm	inbred	8	both	12-16wks	N=4	2003

Crabbe4	19103	dowel balance test	ethanol	latency to fall, 30 min post-injection [s] 9.5mm 15.8mm	inbred	8	both	12-16wks	N=4	2003

Crabbe4	19106	grip strength	ethanol	grip strength test: peak force applied [g] baseline 30min after ethanol	inbred	21	both	7-12wks	N=6	2003

Crabbe4	19108	grip strength	ethanol	change in peak force applied (T0-T30) post-injection, grip strength test [g] gripEtOHeffect	inbred	21	both	7-12wks	N=6	2003

Crabbe4	19109	grip strength	ethanol	percent change in average latency to fall post-injection, grip strength test [%] pct_gripchange	inbred	21	both	7-12wks	N=6	2003

Crabbe4	19111	alcohol quantification	ethanol	blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test [mg/mL] BEC_dowel15_8	inbred	8	both	12-16wks	N=3	2003

Crabbe4	19112	alcohol quantification	ethanol	blood ethanol concentration [mg/mL] time after ethanol: 30min 60min 105min 150min	inbred	21	both	7-12wks	N=6	2003

Crabbe5	19601	parallel rod floor test	ethanol	distance traveled, 1.6mm rod, 6mm space [cm] day1 control day2 control day3 ethanol	inbred	8	both	8-10wks	N=6	2005

Crabbe5	19603	parallel rod floor test	ethanol	motor incoordination, errors over distance traveled, 1.6mm rod, 6mm space [n/cm] day1 control day2 control day3 ethanol	inbred	8	both	7-14wks	N=6	2005

Metten1	16501	open field test	ethanol	line crossings, 2.75 g/kg i.p. [n] pre-injection 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1	16502	open field test	ethanol	line crossings, 3.0 g/kg i.p. [n] pre-injection 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1	16509	behavior observation	ethanol	hindlimb splay, 2.75 g/kg i.p. [score] 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1	16511	behavior observation	ethanol	hindlimb splay, 3.0 g/kg i.p. [score] 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1	16513	behavior observation	ethanol	erratic gait, 2.75 g/kg i.p. [score] 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten1	16515	behavior observation	ethanol	erratic gait, 3.0 g/kg i.p. [score] 10min after injection 30min after	inbred	9	both	8-11wks	N=4	2004

Metten2	19503	behavior observation	ethanol	peak handling-induced convulsion (HIC) score [score] control ethanol ethanol normalized to controls	inbred	15	m	8-15wks	N=9	2005

Metten2	19506	behavior observation	ethanol	latency to first handling-induced convulsions score used to calculate peak ethanol [h] peak_latency	inbred	15	m	8-15wks	N=11	2005

Metten2	19507	behavior observation	ethanol	withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores [AUC] withdrawal_EtOH	inbred	15	m	8-15wks	N=20	2005

Metten2	19508	behavior observation	ethanol	withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores normalized to controls [AUC] withdrawal_EtOHadj	inbred	14	m	8-15wks	N=11	2005

Bennett3

37501

ethanol

blood ethanol concentration (BEC) [mg/mL] first loss of balance (ataxia) first regain of balance second regain of balance

ILSXISS w/par

72

both

8-14wks

N=5

2007

Bennett3

37504

alcohol quantification

ethanol

acute functional tolerance to ethanol (BEC2-BEC1) [mg/mL] AFT1

ILSXISS w/par

72

both

8-14wks

N=5

2007

Bennett3

37505

alcohol quantification

ethanol

acute functional tolerance to ethanol (BEC2-BEC0) [mg/mL] AFT2

ILSXISS w/par

72

both

8-14wks

N=5

2007

Chesler6

27104

rotarod

ethanol

latency difference, two trial post alcohol average minus pre trial latency to fall off rotarod [s] Rotarod_atax

QTL population

both

9-34wks

N=186

2012

Chesler6

27105

body temperature

ethanol

post alcohol minus pre alcohol body temperature [° C] Hypotherm

QTL population

both

9-34wks

N=186

2012

Chesler6

27106

behavior observation

ethanol

alcohol induced loss of righting reflex, latency to return of reflex [s] LORR

QTL population

both

9-34wks

N=186

2012

Chesler6

27107

alcohol quantification

ethanol

blood ethanol concentration at return of righting reflex [mg/mL] LORR_BEC

QTL population

both

9-34wks

N=186

2012

Chesler6

27109

rotarod

ethanol

latency to fall, first alcohol trial [s] RotaTest1

QTL population

both

9-34wks

N=186

2012

Crabbe1

15403

balance beam

ethanol

missteps crossing 12.7mm wide balance beam [n] dose (g/kg) control 1.0 1.2 1.4

inbred

7

both

8-16wks

N=3

2003

Crabbe1

15404

balance beam

ethanol

missteps crossing 15.8mm wide balance beam [n] dose (g/kg): control 1.0 1.2 1.4

inbred

8

both

8-16wks

N=3

2003

Crabbe1

15405

balance beam

ethanol

missteps crossing 19.0 mm wide balance beam [n] dose (g/kg) control 1.0 1.2 1.4

inbred

8

both

8-16wks

N=3

2003

Crabbe1

15406

grid test

ethanol

grid habituation, distance traveled [cm] dose (g/kg): control 1.5 2.0 2.5

inbred

8

both

8-16wks

N=12

2003

Crabbe1

15407

grid test

ethanol

grid habituation, missteps per cm [n/cm] dose (g/kg): control 1.5 2.0 2.5

inbred

8

both

8-16wks

N=12

2003

Crabbe3

15810

rotarod

ethanol

latency to fall, fixed speed 3 rpm rotarod [s] dose (g/kg): 1 2 3

inbred

9

both

9-17wks

N=4

2003

Crabbe3

15815

rotarod

ethanol

latency to fall, fixed speed 6 rpm rotarod [s] dose (g/kg) 1 2 3

inbred

9

both

9-17wks

N=3

2003

Crabbe3

15820

rotarod

ethanol

latency to fall, fixed speed 10 rpm rotarod [s] dose (g/kg): 1 2 3

inbred

7

both

9-17wks

N=3

2003

Crabbe3

15840

rotarod

ethanol

latency to-fall, accelerating rotarod, test day 1 20 rpm/min (ARR1) [s] baseline ethanol difference

inbred

8

both

9-17wks

N=6

2003

Crabbe3

15845

rotarod

ethanol

latency to-fall, accelerating rotarod, test day 2 30 rpm/min (ARR1) [s] baseline ethanol difference

inbred

8

both

9-17wks

N=6

2003

Crabbe3

15855

rotarod

ethanol

latency to fall, accelerating rotarod, 20 rpm/min (ARR2) [s] baseline ethanol

inbred

21

both

9-17wks

N=9

2003

Crabbe3

15857

rotarod

ethanol

average latency to fall, accelerating rotarod, 20 rpm/min (ARR2), post-injection trials minus pre-injection trials (ETPOST - ETBASE) [s] ARR2_chg_20rpm

inbred

21

both

9-17wks

N=9

2003

Crabbe4

19101

vertical wire mesh

ethanol

latency to fall from a vertical wire mesh grid 30 min post-injection [s] latency_screen30

inbred

8

both

9-10wks

N=5

2003

Crabbe4

19102

dowel balance test

ethanol

latency to fall, 0 min post-injection [s] 9.5mm 15.8mm

inbred

8

both

12-16wks

N=4

2003

Crabbe4

19103

dowel balance test

ethanol

latency to fall, 30 min post-injection [s] 9.5mm 15.8mm

inbred

8

both

12-16wks

N=4

2003

Crabbe4

19106

grip strength

ethanol

grip strength test: peak force applied [g] baseline 30min after ethanol

inbred

21

both

7-12wks

N=6

2003

Crabbe4

19108

grip strength

ethanol

change in peak force applied (T0-T30) post-injection, grip strength test [g] gripEtOHeffect

inbred

21

both

7-12wks

N=6

2003

Crabbe4

19109

grip strength

ethanol

percent change in average latency to fall post-injection, grip strength test [%] pct_gripchange

inbred

21

both

7-12wks

N=6

2003

Crabbe4

19111

alcohol quantification

ethanol

blood ethanol concentration (BEC), 35 min post-injection, dowel (15.8 mm) test [mg/mL] BEC_dowel15_8

inbred

8

both

12-16wks

N=3

2003

Crabbe4

19112

alcohol quantification

ethanol

blood ethanol concentration [mg/mL] time after ethanol: 30min 60min 105min 150min

inbred

21

both

7-12wks

N=6

2003

Crabbe5

19601

parallel rod floor test

ethanol

distance traveled, 1.6mm rod, 6mm space [cm] day1 control day2 control day3 ethanol

inbred

8

both

8-10wks

N=6

2005

Crabbe5

19603

parallel rod floor test

ethanol

motor incoordination, errors over distance traveled, 1.6mm rod, 6mm space [n/cm] day1 control day2 control day3 ethanol

inbred

8

both

7-14wks

N=6

2005

Metten1

16501

open field test

ethanol

line crossings, 2.75 g/kg i.p. [n] pre-injection 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

16502

open field test

ethanol

line crossings, 3.0 g/kg i.p. [n] pre-injection 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

16509

behavior observation

ethanol

hindlimb splay, 2.75 g/kg i.p. [score] 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

16511

behavior observation

ethanol

hindlimb splay, 3.0 g/kg i.p. [score] 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

16513

behavior observation

ethanol

erratic gait, 2.75 g/kg i.p. [score] 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten1

16515

behavior observation

ethanol

erratic gait, 3.0 g/kg i.p. [score] 10min after injection 30min after

inbred

9

both

8-11wks

N=4

2004

Metten2

19503

behavior observation

ethanol

peak handling-induced convulsion (HIC) score [score] control ethanol ethanol normalized to controls

inbred

15

m

8-15wks

N=9

2005

Metten2

19506

behavior observation

ethanol

latency to first handling-induced convulsions score used to calculate peak ethanol [h] peak_latency

inbred

15

m

8-15wks

N=11

2005

Metten2

19507

behavior observation

ethanol

withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores [AUC] withdrawal_EtOH

inbred

15

m

8-15wks

N=20

2005

Metten2

19508

behavior observation

ethanol

withdrawal severity during 0-25h, area under curve of handling-induced convulsions scores normalized to controls [AUC] withdrawal_EtOHadj

inbred

14

m

8-15wks

N=11

2005