MPD: Measures involving cocaine

Sort/ Pick	Data set	Procedure / Protocol	Drug or Challenge	Phenotype Measure	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Dickson2:31	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, mean number of infusions (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_infusions_mean 54831	DO population		both	12-16wks	N=35	2015

Dickson2:32	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, mean number of responses on the active lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_active_mean 54832	DO population		both	12-16wks	N=35	2015

Dickson2:33	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, mean number of responses on the inactive lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_inactive_mean 54833	DO population		both	12-16wks	N=35	2015

Dickson2:41	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, breakpoint for infusions (progressive ratio (PR) schedule), one 6h test [n] PR_infusions_breakpoint 54841	DO population		both	12-16wks	N=31	2015

Dickson2:42	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, number of presses on the active lever (progressive ratio (PR) schedule), one 6h test [n] PR_active 54842	DO population		both	12-16wks	N=31	2015

Dickson2:43	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, number of presses on the inactive lever (progressive ratio (PR) schedule), one 6h test [n] PR_inactive 54843	DO population		both	12-16wks	N=31	2015

Jentsch2:1	Jentsch2	operant conditioning chamber	cocaine	number of sessions (days) required to reach criteria for self-administration (FR1 reinforcement schedule) [d] acquisition_FR1 49701	BXD	4	both	8-17wks	N=8	2013

Jentsch2:2	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 1 - self administration: number of infusions earned [n] infusions_FR1 49702 day 1 day 3 day 5 last day	BXD	4	both	8-17wks	N=8	2013

Jentsch2:6	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 1 - discrimination index between active and inactive levers [%] discrimination_FR1 49706 day 1 day 3 day 5 last day	BXD	4	both	8-17wks	N=7	2013

Jentsch2:10	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 1 - time-out: number of responses [n] timeout_FR1 49710 day 1 day 3 day 5 last day	BXD	4	both	8-17wks	N=7	2013

Jentsch2:14	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 2 - self administration: number of infusions earned [n] infusions_FR2 49714 day 1 day 2 day 4	BXD	4	both	8-17wks	N=6	2013

Jentsch2:17	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 2 - discrimination index between active and inactive levers [%] discrimination_FR2 49717 day 1 day 2 day 4	BXD	4	both	8-17wks	N=6	2013

Jentsch2:20	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 2 - time-out: number of responses [n] timeout_FR2 49720 day 1 day 2 day 4	BXD	4	both	8-17wks	N=6	2013

Jentsch2:23	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 5 - self administration: number of infusions earned [n] infusions_FR5 49723 day 1 day 3 day 5	BXD	4	both	8-17wks	N=6	2013

Jentsch2:26	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 5 - discrimination index between active and inactive levers [%] discrimination_FR5 49726 day 1 day 3 day 5	BXD	4	both	8-17wks	N=6	2013

Jentsch2:29	Jentsch2	operant conditioning chamber	cocaine	Fixed ratio 5 - time-out: number of responses [n] timeout_FR5 49729 day 1 day 3 day 5	BXD	4	both	8-17wks	N=6	2013

Jentsch2:32	Jentsch2	operant conditioning chamber	cocaine	horizontal beam breaks [n] activity 49732 baseline 5 mg/kg 10 mg/kg 20 mg/kg	BXD	4	f	8-17wks	N=13	2013

Kumar1:1	Kumar1	circadian wheel running	cocaine	cocaine response over 30 minutes; data are averaged in 5 minute bins and then summed over 30 minutes [cm x 100] 1sum_5min_avg 29001	QTL population		both	10-14wks	N=122	2014

Kumar1:2	Kumar1	circadian wheel running	cocaine	cocaine response over 60 minutes; data are averaged in 5 minute bins and then summed over 60 minutes [cm x 100] 1sum_60min 29002	QTL population		both	10-14wks	N=122	2014

Kumar1:4	Kumar1	circadian wheel running	cocaine	average speed over 30 minutes after cocaine response [cm x 100 / min] 130avg 29004	QTL population		both	10-14wks	N=122	2014

Kumar1:5	Kumar1	circadian wheel running	cocaine	net response–baselineavg subtracted from 30avg [cm x 100 / min] 1resp-baseline 29005	QTL population		both	10-14wks	N=122	2014

Tarantino1:11	Tarantino1	open field test	cocaine	distance traveled, 30 min test [cm] dist 45911 baseline treated difference	inbred	45	m	8-11wks	N=18	2015

Tarantino1:16	Tarantino1	open field test	cocaine	ambulatory episodes, 30 min test [n] amb_epi 45916 baseline treated difference	inbred	45	m	8-11wks	N=18	2015

Tarantino1:21	Tarantino1	open field test	cocaine	rearing episodes, 30 min test [n] rear 45921 baseline treated difference	inbred	45	m	8-11wks	N=18	2015

Tarantino1:26	Tarantino1	open field test	cocaine	average velocity, 30 min test [cm/s] vel 45926 baseline treated difference	inbred	45	m	8-11wks	N=18	2015

Tarantino1:31	Tarantino1	open field test	cocaine	percentage of time resting, 30 min test [%] rest 45931 baseline treated difference	inbred	45	m	8-11wks	N=18	2015

Thomsen1:1	Thomsen1	open field test	cocaine	total activity, test 1, 3h test [n] activ_cocaine1 40701 baseline dose mg/kg i.p.: 3 10 18 32 56	inbred	15	both	8-10wks	N=8	2011

Thomsen1:7	Thomsen1	open field test	cocaine	total activity, test 2, 3h test [n] activ_cocaine2 40707 baseline dose mg/kg i.p.: 3 10 32	inbred	15	both	8-10wks	N=8	2011

Dickson2

cocaine

intravenous self-administration, mean number of infusions (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_infusions_mean 54831

DO population

both

12-16wks

N=35

2015

Dickson2

operant conditioning chamber

cocaine

intravenous self-administration, mean number of responses on the active lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_active_mean 54832

DO population

both

12-16wks

N=35

2015

Dickson2

operant conditioning chamber

cocaine

intravenous self-administration, mean number of responses on the inactive lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_inactive_mean 54833

DO population

both

12-16wks

N=35

2015

Dickson2

operant conditioning chamber

cocaine

intravenous self-administration, breakpoint for infusions (progressive ratio (PR) schedule), one 6h test [n] PR_infusions_breakpoint 54841

DO population

both

12-16wks

N=31

2015

Dickson2

operant conditioning chamber

cocaine

intravenous self-administration, number of presses on the active lever (progressive ratio (PR) schedule), one 6h test [n] PR_active 54842

DO population

both

12-16wks

N=31

2015

Dickson2

operant conditioning chamber

cocaine

intravenous self-administration, number of presses on the inactive lever (progressive ratio (PR) schedule), one 6h test [n] PR_inactive 54843

DO population

both

12-16wks

N=31

2015

Jentsch2

operant conditioning chamber

cocaine

number of sessions (days) required to reach criteria for self-administration (FR1 reinforcement schedule) [d] acquisition_FR1 49701

BXD

4

both

8-17wks

N=8

2013

Jentsch2

operant conditioning chamber

cocaine

Fixed ratio 1 - self administration: number of infusions earned [n] infusions_FR1 49702 day 1 day 3 day 5 last day

BXD

4

both

8-17wks

N=8

2013

Jentsch2

operant conditioning chamber

cocaine

Fixed ratio 1 - discrimination index between active and inactive levers [%] discrimination_FR1 49706 day 1 day 3 day 5 last day

BXD

4

both

8-17wks

N=7

2013

Jentsch2

operant conditioning chamber

cocaine

Fixed ratio 1 - time-out: number of responses [n] timeout_FR1 49710 day 1 day 3 day 5 last day

BXD

4

both

8-17wks

N=7

2013

Jentsch2

operant conditioning chamber

cocaine

Fixed ratio 2 - self administration: number of infusions earned [n] infusions_FR2 49714 day 1 day 2 day 4

BXD

4

both

8-17wks

N=6

2013

Jentsch2

operant conditioning chamber

cocaine

Fixed ratio 2 - discrimination index between active and inactive levers [%] discrimination_FR2 49717 day 1 day 2 day 4

BXD

4

both

8-17wks

N=6

2013

Jentsch2

operant conditioning chamber

cocaine

Fixed ratio 2 - time-out: number of responses [n] timeout_FR2 49720 day 1 day 2 day 4

BXD

4

both

8-17wks

N=6

2013

Jentsch2

operant conditioning chamber

cocaine

Fixed ratio 5 - self administration: number of infusions earned [n] infusions_FR5 49723 day 1 day 3 day 5

BXD

4

both

8-17wks

N=6

2013

Jentsch2

operant conditioning chamber

cocaine

Fixed ratio 5 - discrimination index between active and inactive levers [%] discrimination_FR5 49726 day 1 day 3 day 5

BXD

4

both

8-17wks

N=6

2013

Jentsch2

operant conditioning chamber

cocaine

Fixed ratio 5 - time-out: number of responses [n] timeout_FR5 49729 day 1 day 3 day 5

BXD

4

both

8-17wks

N=6

2013

Jentsch2

operant conditioning chamber

cocaine

horizontal beam breaks [n] activity 49732 baseline 5 mg/kg 10 mg/kg 20 mg/kg

BXD

4

f

8-17wks

N=13

2013

Kumar1

circadian wheel running

cocaine

cocaine response over 30 minutes; data are averaged in 5 minute bins and then summed over 30 minutes [cm x 100] 1sum_5min_avg 29001

QTL population

both

10-14wks

N=122

2014

Kumar1

circadian wheel running

cocaine

cocaine response over 60 minutes; data are averaged in 5 minute bins and then summed over 60 minutes [cm x 100] 1sum_60min 29002

QTL population

both

10-14wks

N=122

2014

Kumar1

circadian wheel running

cocaine

average speed over 30 minutes after cocaine response [cm x 100 / min] 130avg 29004

QTL population

both

10-14wks

N=122

2014

Kumar1

circadian wheel running

cocaine

net response–baselineavg subtracted from 30avg [cm x 100 / min] 1resp-baseline 29005

QTL population

both

10-14wks

N=122

2014

Tarantino1

open field test

cocaine

distance traveled, 30 min test [cm] dist 45911 baseline treated difference

inbred

45

m

8-11wks

N=18

2015

Tarantino1

open field test

cocaine

ambulatory episodes, 30 min test [n] amb_epi 45916 baseline treated difference

inbred

45

m

8-11wks

N=18

2015

Tarantino1

open field test

cocaine

rearing episodes, 30 min test [n] rear 45921 baseline treated difference

inbred

45

m

8-11wks

N=18

2015

Tarantino1

open field test

cocaine

average velocity, 30 min test [cm/s] vel 45926 baseline treated difference

inbred

45

m

8-11wks

N=18

2015

Tarantino1

open field test

cocaine

percentage of time resting, 30 min test [%] rest 45931 baseline treated difference

inbred

45

m

8-11wks

N=18

2015

Thomsen1

open field test

cocaine

total activity, test 1, 3h test [n] activ_cocaine1 40701 baseline dose mg/kg i.p.: 3 10 18 32 56

inbred

15

both

8-10wks

N=8

2011

Thomsen1

open field test

cocaine

total activity, test 2, 3h test [n] activ_cocaine2 40707 baseline dose mg/kg i.p.: 3 10 32

inbred

15

both

8-10wks

N=8

2011