MPD: Measures involving cocaine

Data set	MPD ID	Procedure / Protocol	Drug or Challenge	Phenotype Measure	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Dickson2	54831	operant conditioning chamber	cocaine	intravenous self-administration, mean number of infusions (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_infusions_mean	DO population		both	12-16wks	N=35	2015

Dickson2	54832	operant conditioning chamber	cocaine	intravenous self-administration, mean number of responses on the active lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_active_mean	DO population		both	12-16wks	N=35	2015

Dickson2	54833	operant conditioning chamber	cocaine	intravenous self-administration, mean number of responses on the inactive lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_inactive_mean	DO population		both	12-16wks	N=35	2015

Dickson2	54841	operant conditioning chamber	cocaine	intravenous self-administration, breakpoint for infusions (progressive ratio (PR) schedule), one 6h test [n] PR_infusions_breakpoint	DO population		both	12-16wks	N=31	2015

Dickson2	54842	operant conditioning chamber	cocaine	intravenous self-administration, number of presses on the active lever (progressive ratio (PR) schedule), one 6h test [n] PR_active	DO population		both	12-16wks	N=31	2015

Dickson2	54843	operant conditioning chamber	cocaine	intravenous self-administration, number of presses on the inactive lever (progressive ratio (PR) schedule), one 6h test [n] PR_inactive	DO population		both	12-16wks	N=31	2015

Jentsch2	49701	operant conditioning chamber	cocaine	number of sessions (days) required to reach criteria for self-administration (FR1 reinforcement schedule) [d] acquisition_FR1	BXD	4	both	8-17wks	N=8	2013

Jentsch2	49702	operant conditioning chamber	cocaine	Fixed ratio 1 - self administration: number of infusions earned [n] day 1 day 3 day 5 last day	BXD	4	both	8-17wks	N=8	2013

Jentsch2	49706	operant conditioning chamber	cocaine	Fixed ratio 1 - discrimination index between active and inactive levers [%] day 1 day 3 day 5 last day	BXD	4	both	8-17wks	N=7	2013

Jentsch2	49710	operant conditioning chamber	cocaine	Fixed ratio 1 - time-out: number of responses [n] day 1 day 3 day 5 last day	BXD	4	both	8-17wks	N=7	2013

Jentsch2	49714	operant conditioning chamber	cocaine	Fixed ratio 2 - self administration: number of infusions earned [n] day 1 day 2 day 4	BXD	4	both	8-17wks	N=6	2013

Jentsch2	49717	operant conditioning chamber	cocaine	Fixed ratio 2 - discrimination index between active and inactive levers [%] day 1 day 2 day 4	BXD	4	both	8-17wks	N=6	2013

Jentsch2	49720	operant conditioning chamber	cocaine	Fixed ratio 2 - time-out: number of responses [n] day 1 day 2 day 4	BXD	4	both	8-17wks	N=6	2013

Jentsch2	49723	operant conditioning chamber	cocaine	Fixed ratio 5 - self administration: number of infusions earned [n] day 1 day 3 day 5	BXD	4	both	8-17wks	N=6	2013

Jentsch2	49726	operant conditioning chamber	cocaine	Fixed ratio 5 - discrimination index between active and inactive levers [%] day 1 day 3 day 5	BXD	4	both	8-17wks	N=6	2013

Jentsch2	49729	operant conditioning chamber	cocaine	Fixed ratio 5 - time-out: number of responses [n] day 1 day 3 day 5	BXD	4	both	8-17wks	N=6	2013

Jentsch2	49732	operant conditioning chamber	cocaine	horizontal beam breaks [n] baseline 5 mg/kg 10 mg/kg 20 mg/kg	BXD	4	f	8-17wks	N=13	2013

Kumar1	29001	circadian wheel running	cocaine	cocaine response over 30 minutes; data are averaged in 5 minute bins and then summed over 30 minutes [cm x 100] 1sum_5min_avg	QTL population		both	10-14wks	N=122	2014

Kumar1	29002	circadian wheel running	cocaine	cocaine response over 60 minutes; data are averaged in 5 minute bins and then summed over 60 minutes [cm x 100] 1sum_60min	QTL population		both	10-14wks	N=122	2014

Kumar1	29004	circadian wheel running	cocaine	average speed over 30 minutes after cocaine response [cm x 100 / min] 130avg	QTL population		both	10-14wks	N=122	2014

Kumar1	29005	circadian wheel running	cocaine	net response–baselineavg subtracted from 30avg [cm x 100 / min] 1resp-baseline	QTL population		both	10-14wks	N=122	2014

Tarantino1	45911	open field test	cocaine	distance traveled, 30 min test [cm] baseline treated difference	inbred	45	m	8-11wks	N=18	2015

Tarantino1	45916	open field test	cocaine	ambulatory episodes, 30 min test [n] baseline treated difference	inbred	45	m	8-11wks	N=18	2015

Tarantino1	45921	open field test	cocaine	rearing episodes, 30 min test [n] baseline treated difference	inbred	45	m	8-11wks	N=18	2015

Tarantino1	45926	open field test	cocaine	average velocity, 30 min test [cm/s] baseline treated difference	inbred	45	m	8-11wks	N=18	2015

Tarantino1	45931	open field test	cocaine	percentage of time resting, 30 min test [%] baseline treated difference	inbred	45	m	8-11wks	N=18	2015

Thomsen1	40701	open field test	cocaine	total activity, test 1, 3h test [n] baseline dose mg/kg i.p.: 3 10 18 32 56	inbred	15	both	8-10wks	N=8	2011

Thomsen1	40707	open field test	cocaine	total activity, test 2, 3h test [n] baseline dose mg/kg i.p.: 3 10 32	inbred	15	both	8-10wks	N=8	2011

Dickson2

54831

cocaine

intravenous self-administration, mean number of infusions (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_infusions_mean

DO population

both

12-16wks

N=35

2015

Dickson2

54832

operant conditioning chamber

cocaine

intravenous self-administration, mean number of responses on the active lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_active_mean

DO population

both

12-16wks

N=35

2015

Dickson2

54833

operant conditioning chamber

cocaine

intravenous self-administration, mean number of responses on the inactive lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_inactive_mean

DO population

both

12-16wks

N=35

2015

Dickson2

54841

operant conditioning chamber

cocaine

intravenous self-administration, breakpoint for infusions (progressive ratio (PR) schedule), one 6h test [n] PR_infusions_breakpoint

DO population

both

12-16wks

N=31

2015

Dickson2

54842

operant conditioning chamber

cocaine

intravenous self-administration, number of presses on the active lever (progressive ratio (PR) schedule), one 6h test [n] PR_active

DO population

both

12-16wks

N=31

2015

Dickson2

54843

operant conditioning chamber

cocaine

intravenous self-administration, number of presses on the inactive lever (progressive ratio (PR) schedule), one 6h test [n] PR_inactive

DO population

both

12-16wks

N=31

2015

Jentsch2

49701

operant conditioning chamber

cocaine

number of sessions (days) required to reach criteria for self-administration (FR1 reinforcement schedule) [d] acquisition_FR1

BXD

4

both

8-17wks

N=8

2013

Jentsch2

49702

operant conditioning chamber

cocaine

Fixed ratio 1 - self administration: number of infusions earned [n] day 1 day 3 day 5 last day

BXD

4

both

8-17wks

N=8

2013

Jentsch2

49706

operant conditioning chamber

cocaine

Fixed ratio 1 - discrimination index between active and inactive levers [%] day 1 day 3 day 5 last day

BXD

4

both

8-17wks

N=7

2013

Jentsch2

49710

operant conditioning chamber

cocaine

Fixed ratio 1 - time-out: number of responses [n] day 1 day 3 day 5 last day

BXD

4

both

8-17wks

N=7

2013

Jentsch2

49714

operant conditioning chamber

cocaine

Fixed ratio 2 - self administration: number of infusions earned [n] day 1 day 2 day 4

BXD

4

both

8-17wks

N=6

2013

Jentsch2

49717

operant conditioning chamber

cocaine

Fixed ratio 2 - discrimination index between active and inactive levers [%] day 1 day 2 day 4

BXD

4

both

8-17wks

N=6

2013

Jentsch2

49720

operant conditioning chamber

cocaine

Fixed ratio 2 - time-out: number of responses [n] day 1 day 2 day 4

BXD

4

both

8-17wks

N=6

2013

Jentsch2

49723

operant conditioning chamber

cocaine

Fixed ratio 5 - self administration: number of infusions earned [n] day 1 day 3 day 5

BXD

4

both

8-17wks

N=6

2013

Jentsch2

49726

operant conditioning chamber

cocaine

Fixed ratio 5 - discrimination index between active and inactive levers [%] day 1 day 3 day 5

BXD

4

both

8-17wks

N=6

2013

Jentsch2

49729

operant conditioning chamber

cocaine

Fixed ratio 5 - time-out: number of responses [n] day 1 day 3 day 5

BXD

4

both

8-17wks

N=6

2013

Jentsch2

49732

operant conditioning chamber

cocaine

horizontal beam breaks [n] baseline 5 mg/kg 10 mg/kg 20 mg/kg

BXD

4

f

8-17wks

N=13

2013

Kumar1

29001

circadian wheel running

cocaine

cocaine response over 30 minutes; data are averaged in 5 minute bins and then summed over 30 minutes [cm x 100] 1sum_5min_avg

QTL population

both

10-14wks

N=122

2014

Kumar1

29002

circadian wheel running

cocaine

cocaine response over 60 minutes; data are averaged in 5 minute bins and then summed over 60 minutes [cm x 100] 1sum_60min

QTL population

both

10-14wks

N=122

2014

Kumar1

29004

circadian wheel running

cocaine

average speed over 30 minutes after cocaine response [cm x 100 / min] 130avg

QTL population

both

10-14wks

N=122

2014

Kumar1

29005

circadian wheel running

cocaine

net response–baselineavg subtracted from 30avg [cm x 100 / min] 1resp-baseline

QTL population

both

10-14wks

N=122

2014

Tarantino1

45911

open field test

cocaine

distance traveled, 30 min test [cm] baseline treated difference

inbred

45

m

8-11wks

N=18

2015

Tarantino1

45916

open field test

cocaine

ambulatory episodes, 30 min test [n] baseline treated difference

inbred

45

m

8-11wks

N=18

2015

Tarantino1

45921

open field test

cocaine

rearing episodes, 30 min test [n] baseline treated difference

inbred

45

m

8-11wks

N=18

2015

Tarantino1

45926

open field test

cocaine

average velocity, 30 min test [cm/s] baseline treated difference

inbred

45

m

8-11wks

N=18

2015

Tarantino1

45931

open field test

cocaine

percentage of time resting, 30 min test [%] baseline treated difference

inbred

45

m

8-11wks

N=18

2015

Thomsen1

40701

open field test

cocaine

total activity, test 1, 3h test [n] baseline dose mg/kg i.p.: 3 10 18 32 56

inbred

15

both

8-10wks

N=8

2011

Thomsen1

40707

open field test

cocaine

total activity, test 2, 3h test [n] baseline dose mg/kg i.p.: 3 10 32

inbred

15

both

8-10wks

N=8

2011