MPD: Data set: Dickson2

Dickson PE, Ndukum J, Wilcox T, Clark J, Roy B, Zhang L, Li Y, Lin DT, Chesler EJ. Association of novelty-related behaviors and intravenous cocaine self-administration in Diversity Outbred mice. Psychopharmacology (Berl). 2015 Mar;232(6):1011-24. doi: 10.1007/s00213-014-3737-5. Epub 2014 Sep 20. PubMed 25238945 FullText

FR = fixed ratio; PR = progressive ratio;

Procedures conducted:

• open field test		Locomotor activity and exploratory behavior. 20 min test.
• hole board test		Exploratory behavior. 10 min test.
• monitoring system		Novelty preference test (preference for novel side vs. familiar side). 10 min test.
• operant conditioning chamber		Intravenous self-administration of cocaine via activation of levers.

Dickson2 downloads
• Download Dickson2 project data set animal data, as uploaded
• Download Dickson2 animal data matrix with factor-related expansion applied as necessary
• Download Dickson2 strain means, SD, N, etc. one row per strain/sex/measure
• Dickson2 supplementary data

Ontology terms mapped to Dickson2 measures:

MP:0001362 abnormal anxiety-related response
MP:0001392 abnormal locomotor behavior
MP:0001988 cocaine preference
MP:0002803 abnormal operant conditioning behavior
MP:0003107 abnormal response to novelty
MP:0010698 abnormal impulsive behavior control
MP:0013189 abnormal exploration in a new environment
MP:0020158 abnormal behavioral response to cocaine
VT:0001392 locomotor behavior trait
VT:0002063 learning/memory/conditioning trait
VT:0010471 exploratory behavior trait
VT:0010473 impulsivity behavior trait
VT:0010531 operant conditioning behavior trait
VT:0010709 behavioral response to novel object trait
VT:0010716 anxiety-related behavior trait

Investigators	Price E Dickson The Jackson Laboratory, Bar Harbor, ME Elissa J Chesler The Jackson Laboratory, Bar Harbor, ME
Participants	Ndukum J, Wilcox T, Clark J, Roy B, Zhang L, Li Y, Lin D-T
Contact	Price E Dickson price.dickson@jax.org
Affiliated Center	Center for Systems Neurogenetics of Addiction (CSNA)
Acknowledgements	Funding provided by NIH CA034196, GM076468; acknowledge support from NIDA Drug Supply Program
Project type	Phenotype strain survey data set
MPD identifiers	Dickson2 MPD:548
Data changelog	No updates/corrections. Initial release date: 06/2016.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	Sex	Age	Sample Size (Avg)
Dickson2:1	Dickson2	open field test	(none)	total distance traveled, 20 min test [cm] OFT_distance 54801	DO population	both	12-16wks	N=48

Dickson2:2	Dickson2	open field test	(none)	time spent in center, 20 min test [s] OFT_center 54802	DO population	both	12-16wks	N=48

Dickson2:11	Dickson2	monitoring system	(none)	percentage of total time spent in chamber with novel wall, 10 min test [%] novel_wall 54811	DO population	both	12-16wks	N=48

Dickson2:21	Dickson2	hole board test	(none)	number of hole pokes, 10 min test [n] hole_pokes 54821	DO population	both	12-16wks	N=46

Dickson2:31	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, mean number of infusions (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_infusions_mean 54831	DO population	both	12-16wks	N=35

Dickson2:32	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, mean number of responses on the active lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_active_mean 54832	DO population	both	12-16wks	N=35

Dickson2:33	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, mean number of responses on the inactive lever (fixed ratio 1 (FR1) schedule), over ten 120 min sessions [n] FR1_inactive_mean 54833	DO population	both	12-16wks	N=35

Dickson2:41	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, breakpoint for infusions (progressive ratio (PR) schedule), one 6h test [n] PR_infusions_breakpoint 54841	DO population	both	12-16wks	N=31

Dickson2:42	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, number of presses on the active lever (progressive ratio (PR) schedule), one 6h test [n] PR_active 54842	DO population	both	12-16wks	N=31

Dickson2:43	Dickson2	operant conditioning chamber	cocaine	intravenous self-administration, number of presses on the inactive lever (progressive ratio (PR) schedule), one 6h test [n] PR_inactive 54843	DO population	both	12-16wks	N=31

Dickson2: Novelty-related behaviors and intravenous cocaine self-administration in a Diversity Outbred (DO) mouse population (2015)