Jentsch2: Drug study: Cocaine self-administration behavior and capacities for inhibitory control in 4 BXD recombinant inbred strains of mice (2013)

Cervantes MC, Laughlin RE, Jentsch JD. Cocaine self-administration behavior in inbred mouse lines segregating different capacities for inhibitory control. Psychopharmacology (Berl). 2013 Oct;229(3):515-25. doi: 10.1007/s00213-013-3135-4. Epub 2013 May 17.   PubMed 23681162     FullText


       
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Participants J D Jentsch       Binghamton University Binghamton, NY
With: Cervantes MC, Laughlin RE
ContactJ D Jentsch     jjentsch@binghamton.edu     Lab web site
Part of a series: • reversal learning, 51 BXD strains   see Jentsch1
• cocaine study, 4 BXD strains   (this project) Jentsch2
AcknowledgementsFunding provided by NIH DA031852, DA024635, DE019580, MH083270, NS062410
Project type Phenotype strain survey data set
MPD identifiersJentsch2     MPD:497
Data changelog No updates/corrections.       Initial release date: 02/2014.
Formatted citation
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Locomotor activity test involved baseline readings while other tests did not, see protocol for details.

Summary of procedures that were conducted
• operant conditioning chamber Intravenous self-administration of cocaine via activation of levers, and locomotor activity.
Mice: BXD   4 strains   ♀♂   age 8-17wks   2 cohorts

Select table page: First Prev Next Last
Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Jentsch2 49701 operant conditioning chamber cocaine number of sessions (days) required to reach criteria for self-administration (FR1 reinforcement schedule)   [d]  acquisition_FR1 BXD 4 both 8-17wks N=8
    Jentsch2 49702 operant conditioning chamber cocaine Fixed ratio 1 - self administration   [n]     day 1    day 3    day 5    last day BXD 4 both 8-17wks N=8
    Jentsch2 49706 operant conditioning chamber cocaine Fixed ratio 1 - discrimination index   [%]     day 1    day 3    day 5    last day BXD 4 both 8-17wks N=7
    Jentsch2 49710 operant conditioning chamber cocaine Fixed ratio 1 - time-out response   [n]     day 1    day 3    day 5    last day BXD 4 both 8-17wks N=7
    Jentsch2 49714 operant conditioning chamber cocaine Fixed ratio 2 - self administration   [n]     day 1    day 2    day 4 BXD 4 both 8-17wks N=6
    Jentsch2 49717 operant conditioning chamber cocaine Fixed ratio 2 - discrimination index   [%]     day 1    day 2    day 4 BXD 4 both 8-17wks N=6
    Jentsch2 49720 operant conditioning chamber cocaine Fixed ratio 2 - time-out response   [n]     day 1    day 2    day 4 BXD 4 both 8-17wks N=6
    Jentsch2 49723 operant conditioning chamber cocaine Fixed ratio 5 - self administration   [n]     day 1    day 3    day 5 BXD 4 both 8-17wks N=6
    Jentsch2 49726 operant conditioning chamber cocaine Fixed ratio 5 - discrimination index   [%]     day 1    day 3    day 5 BXD 4 both 8-17wks N=6
    Jentsch2 49729 operant conditioning chamber cocaine Fixed ratio 5 - time-out response   [n]     day 1    day 3    day 5 BXD 4 both 8-17wks N=6
    Jentsch2 49732 operant conditioning chamber cocaine horizontal beam breaks   [n]     baseline    5 mg/kg    10 mg/kg    20 mg/kg BXD 4 f 8-17wks N=13
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