Wahlsten1: Survey of motor activity, behavior, and forebrain morphometry in 21 inbred strains of mice across two laboratories (2003)

Wahlsten D, Metten P, Crabbe JC. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res. 2003 May 2;971(1):47-54.   PubMed 12691836  

Wahlsten D, Bachmanov A, Finn DA, Crabbe JC. Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16364-9. Epub 2006 Oct 19.   PubMed 17053075  

Test site is noted on each row in the project data set.

Wahlsten1 downloads
• Download Wahlsten1 project data set     animal data, as uploaded
• Download Wahlsten1 animal data matrix     with factor-related expansion applied as necessary
• Download Wahlsten1 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Douglas Wahlsten       University of Windsor,  Windsor, Ontario CANADA
John C Crabbe       Oregon Health & Science University,  Portland, OR
Participants Bachmanov A, Finn DA, Cooper S, Bryden C, Metten P, Sibert J, Moisan B
ContactDouglas Wahlsten     dlwahlst@uncg.edu
AcknowledgementsFunding provided by NIH AA12714, AA10760, AA10270, AA13519; Department of Veterans Affairs; Natural Sciences and Engineering Research Council of Canada (NSERC 45825)

Generous funds from AstraZeneca were used to defray the cost of mice through the Mouse Phenome Project Collaborations Program.
Project type Phenotype strain survey data set
MPD identifiersWahlsten1     MPD:108
Data changelog 1 update/correction.       Initial release date: 07/2003.
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This study was conducted on the same set of mice rated for wildness and ease of handling (Wahlsten2). Wahlsten1 data were measured at two different sites, Edmonton and Portland. The data were pooled to compute strain means for the above MPD measurements. A study of the comparability / reproducability of results across the two testing sites is available: Wahlsten1_sitecorrs.csv

Procedures conducted:
• organ weights  Brain weight.
• open field test  Locomotor, exploratory, and anxiety-related behavior. 5 min test.
• elevated plus maze  Locomotor, exploratory, and anxiety-related behavior.
• histopathology  Corpus callosum, hippocampus, anterior commisure.

Mice: inbred   21 strains   ♀♂   age 9, 12 wks   1 experimental group