MPD: Data set: Wahlsten1

Wahlsten D, Metten P, Crabbe JC. Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum. Brain Res. 2003 May 2;971(1):47-54. PubMed 12691836

Wahlsten D, Bachmanov A, Finn DA, Crabbe JC. Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16364-9. Epub 2006 Oct 19. PubMed 17053075

This study was conducted on the same set of mice rated for wildness and ease of handling (Wahlsten2). Wahlsten1 data were measured at two different sites, Edmonton and Portland. The data were pooled to compute strain means for the above MPD measurements. A study of the comparability / reproducability of results across the two testing sites is available: Wahlsten1_sitecorrs.csv

Procedures conducted:

• organ weights		Brain weight.
• open field test		Locomotor, exploratory, and anxiety-related behavior. 5 min test.
• elevated plus maze		Locomotor, exploratory, and anxiety-related behavior.
• histopathology		Corpus callosum, hippocampus, anterior commisure.

Notes
Test site is noted on each row in the project data set.

Wahlsten1 downloads
• Download Wahlsten1 project data set animal data, as uploaded
• Download Wahlsten1 animal data matrix with factor-related expansion applied as necessary
• Download Wahlsten1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Wahlsten1 measures:

MA:0000168 brain
MA:0000188 corpus callosum
MA:0002723 hippocampal commissure
MP:0000771 abnormal brain size
MP:0000780 abnormal corpus callosum morphology
MP:0001362 abnormal anxiety-related response
MP:0001392 abnormal locomotor behavior
MP:0008221 abnormal hippocampal commissure morphology
MP:0008225 abnormal anterior commissure morphology
MP:0013189 abnormal exploration in a new environment
MP:0020147 abnormal defecation amount
VT:0000771 brain size trait
VT:0000781 corpus callosum size trait
VT:0000807 hippocampus morphology trait
VT:0001392 locomotor behavior trait
VT:0002176 brain mass
VT:0002199 brain commissure morphology trait
VT:0010462 defecation behavior trait
VT:0010471 exploratory behavior trait
VT:0010716 anxiety-related behavior trait

Investigators	Douglas Wahlsten University of Windsor, Windsor, Ontario CANADA John C Crabbe Oregon Health & Science University, Portland, OR
Participants	Bachmanov A, Finn DA, Cooper S, Bryden C, Metten P, Sibert J, Moisan B
Contact	Douglas Wahlsten dlwahlst@uncg.edu
Acknowledgements	Funding provided by NIH AA12714, AA10760, AA10270, AA13519; Department of Veterans Affairs; Natural Sciences and Engineering Research Council of Canada (NSERC 45825) Generous funds from AstraZeneca were used to defray the cost of mice through the Mouse Phenome Project Collaborations Program.
Project type	Phenotype strain survey data set
MPD identifiers	Wahlsten1 MPD:108
Data changelog	1 update/correction. Initial release date: 07/2003.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Wahlsten1:3	Wahlsten1	body weight	(none)	body weight, end of testing (local parameter) [g] bw 10803	inbred	21	both	12wks	N=10

Wahlsten1:4	Wahlsten1	organ weights	(none)	brain weight, after fixation and trimming [g] brain_wt 10804 weight as percent of body weight	inbred	21	both	12wks	N=10

Wahlsten1:5	Wahlsten1	colony observation	(none)	tissue quality; 0=no faults, 1=one or more faults (local parameter) [score] tissue 10805	inbred	21	both	12wks	N=10

Wahlsten1:6	Wahlsten1	histopathology	(none)	length of corpus callosum at mid-sagittal plane [mm] cc_length 10806	inbred	21	both	12wks	N=10

Wahlsten1:7	Wahlsten1	histopathology	(none)	length of hippocampal commissure at mid-sagittal plane [mm] hc_length 10807	inbred	21	both	12wks	N=10

Wahlsten1:8	Wahlsten1	histopathology	(none)	length of anterior commissure at mid-sagittal plane [mm] ac_length 10808	inbred	21	both	12wks	N=10

Wahlsten1:9	Wahlsten1	histopathology	(none)	cross-sectional area of corpus callosum at midplane [mm²] cc_area 10809	inbred	21	both	12wks	N=10

Wahlsten1:10	Wahlsten1	histopathology	(none)	cross-sectional area of hippocampal commissure at midplane [mm²] hc_area 10810	inbred	21	both	12wks	N=10

Wahlsten1:11	Wahlsten1	histopathology	(none)	cross-sectional area of anterior commissure at midplane [mm²] ac_area 10811	inbred	21	both	12wks	N=10

Wahlsten1:12	Wahlsten1	histopathology	(none)	corpus callosum index (0=absent, 1=normal, <0.65 is abnormal) [score] cc_index 10812	inbred	21	both	12wks	N=10

Wahlsten1:13	Wahlsten1	histopathology	(none)	hippocampal commissure index (0=absent, 1=normal, <0.5 is abnormal) [score] hc_index 10813	inbred	21	both	12wks	N=10

Wahlsten1:14	Wahlsten1	histopathology	(none)	anterior commissure index (0=absent, 1=normal, <.60 is abnormal) [score] ac_index 10814	inbred	21	both	12wks	N=10

Wahlsten1:20	Wahlsten1	open field test	(none)	distance traveled in 1 min [cm] dist_OFT 10820 during minute: 1 2 3 4 5	inbred	21	both	9wks	N=9

Wahlsten1:25	Wahlsten1	open field test	(none)	average speed over 5 min trial [cm/sec] speed_ave_OFT 10825	inbred	21	both	9wks	N=9

Wahlsten1:31	Wahlsten1	open field test	(none)	percentage of 5 min spent within 10 cm of wall [%] pct_thigmotaxia 10831	inbred	21	both	9wks	N=9

Wahlsten1:32	Wahlsten1	open field test	(none)	number of fecal boli, within 5 min trial [n] defecation_OFT 10832	inbred	21	both	9wks	N=9

Wahlsten1:33	Wahlsten1	open field test	(none)	average distance traveled in 1 min [cm] dist_ave_OFT 10833	inbred	21	both	9wks	N=9

Wahlsten1:40	Wahlsten1	elevated plus maze	(none)	distance traveled in 1 min [cm] dist_EPM 10840 1 2 3 4 5	inbred	21	both	9wks	N=9

Wahlsten1:45	Wahlsten1	elevated plus maze	(none)	percentage of time spent moving; average of 5 min [%] pct_move 10845	inbred	21	both	9wks	N=9

Wahlsten1:46	Wahlsten1	elevated plus maze	(none)	speed when moving; average over 5 min [cm/sec] speed_ave_EPM 10846	inbred	21	both	9wks	N=9

Wahlsten1:50	Wahlsten1	elevated plus maze	(none)	time spent in two closed arms [s] close 10850	inbred	21	both	9wks	N=9

Wahlsten1:51	Wahlsten1	elevated plus maze	(none)	number fecal boli, 5 min trial [n] defecation_EPM 10851	inbred	21	both	9wks	N=9

Wahlsten1:52	Wahlsten1	elevated plus maze	(none)	percentage of time spent in open arms vs closed [%] pct_open 10852	inbred	21	both	9wks	N=9

Wahlsten1:53	Wahlsten1	elevated plus maze	(none)	average distance traveled in 1 min [cm] dist_ave_EPM 10853	inbred	21	both	9wks	N=9

Wahlsten1:54	Wahlsten1	elevated plus maze	(none)	time spent in center 5 x 5 cm hub [s] center 10854	inbred	21	both	9wks	N=9

Wahlsten1:55	Wahlsten1	elevated plus maze	(none)	time spent in two open arms [s] open 10855	inbred	21	both	9wks	N=9

Wahlsten1: Survey of motor activity, behavior, and forebrain morphometry in 21 inbred strains of mice across two laboratories (2003)

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