MPD: Measures involving trichloroethylene

Data set	MPD ID	Procedure / Protocol	Drug or Challenge	Phenotype Measure	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Rusyn2	36112	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), control group [IU/L] time: 2h 8h 24h	inbred	16	m	7wks	N=3	2010

Rusyn2	36117	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), treated group [IU/L] time: 2h 8h 24h	inbred	16	m	7wks	N=3	2010

Rusyn2	36122	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), control group [IU/L] time: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2	36127	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), treated group [IU/L] time: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2	36132	metabolic panel	trichloroethylene	blood urea nitrogen (serum BUN), control group [mg/dL] time: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2	36137	metabolic panel	trichloroethylene	blood urea nitrogen (serum BUN), treated group [mg/dL] time: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2	36167	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2	36175	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (serum TCA) [nmol/mL] time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2	36185	drug and metabolite quantification	trichloroethylene	DCV cysteine (serum DCVC x 10^-3) [nmol/mL] time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=2	2010

Rusyn2	36195	drug and metabolite quantification	trichloroethylene	DCV glutathione (serum DCVG x 10^-3) [nmol/mL] time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=2	2010

Rusyn6	51202	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (serum TCA) [nmol/mL] TCA_serum_tce	inbred	7	m	6-7wks	N=3	2014

Rusyn6	51204	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (serum DCA) [nmol/mL] DCA_serum_tce	inbred	7	m	6-7wks	N=3	2014

Rusyn6	51206	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl) glutathione (serum DCVG) [pmol/mL] DCVG_serum_tce	inbred	4	m	6-7wks	N=2	2014

Rusyn6	51208	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl)-L-cysteine (serum DCVC) [pmol/mL] DCVC_serum_tce	inbred	7	m	6-7wks	N=3	2014

Rusyn6	51209	metabolic panel	trichloroethylene	blood urea nitrogen (serum BUN) [mg/dL] control TCE	inbred	7	m	6-7wks	N=4	2014

Rusyn6	51211	organ weights	trichloroethylene	liver weight as a percent of body weight [%] control TCE	inbred	7	m	6-7wks	N=4	2014

Rusyn6	51214	histopathology	trichloroethylene	BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group [%] BrdU_liver_tce	inbred	7	m	6-7wks	N=3	2014

Rusyn6	51216	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (liver TCA) [nmol/g] TCA_liver_tce	inbred	7	m	6-7wks	N=4	2014

Rusyn6	51218	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (liver DCA) [nmol/g] DCA_liver_tce	inbred	7	m	6-7wks	N=4	2014

Rusyn6	51220	drug and metabolite quantification	trichloroethylene	trichloroethanol (liver TCOH) [nmol/g] TCOH_liver_tce	inbred	7	m	6-7wks	N=4	2014

Rusyn6	51222	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl) glutathione (liver DCVG) [pmol/g] DCVG_liver_tce	inbred	7	m	6-7wks	N=4	2014

Rusyn6	51226	RNA expression profiling	trichloroethylene	Acox1, mRNA in liver, relative to control group [ratio] Acox1_liver_tce	inbred	7	m	6-7wks	N=3	2014

Rusyn6	51228	RNA expression profiling	trichloroethylene	Cyp4a10, mRNA in liver, relative to control group [ratio] Cyp4a10_liver_tce	inbred	7	m	6-7wks	N=3	2014

Rusyn6	51230	RNA expression profiling	trichloroethylene	Ppara, mRNA in liver, relative to control group [ratio] Ppara_liver_tce	inbred	7	m	6-7wks	N=3	2014

Rusyn6	51251	organ weights	trichloroethylene	kidney weight as a percent of body weight [%] control TCE	inbred	7	m	6-7wks	N=4	2014

Rusyn6	51254	histopathology	trichloroethylene	BrdU-positive nuclei in kidney (proximal tubule cell proliferation), relative to control group [%] BrdU_kidney_tce	inbred	7	m	6-7wks	N=3	2014

Rusyn6	51255	histopathology	trichloroethylene	kidney injury molecule 1 (KIM-1) positive proximal tubules [%] control TCE	inbred	7	m	6-7wks	N=4	2014

Rusyn6	51258	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (kidney TCA) [nmol/g] TCA_kidney_tce	inbred	7	m	6-7wks	N=4	2014

Rusyn6	51260	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (kidney DCA) [nmol/g] DCA_kidney_tce	inbred	6	m	6-7wks	N=3	2014

Rusyn6	51262	drug and metabolite quantification	trichloroethylene	trichloroethanol (kidney TCOH) [nmol/g] TCOH_kidney_tce	inbred	7	m	6-7wks	N=4	2014

Rusyn6	51264	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl) glutathione (kidney DCVG) [pmol/g] DCVG_kidney_tce	inbred	6	m	6-7wks	N=2	2014

Rusyn6	51266	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl)-L-cysteine (kidney DCVC) [pmol/g] DCVC_kidney_tce	inbred	6	m	6-7wks	N=2	2014

Rusyn6	51268	RNA expression profiling	trichloroethylene	Acox1, mRNA in kidney, relative to control group [ratio] Acox1_kidney_tce	inbred	7	m	6-7wks	N=3	2014

Rusyn6	51270	RNA expression profiling	trichloroethylene	Cyp4a10, mRNA in kidney, relative to control group [ratio] Cyp4a10_kidney_tce	inbred	7	m	6-7wks	N=3	2014

Rusyn6	51272	RNA expression profiling	trichloroethylene	Ppara, mRNA in kidney, relative to control group [ratio] Ppara_kidney_tce	inbred	7	m	6-7wks	N=3	2014

Rusyn2

36112

metabolic panel

trichloroethylene

alanine transaminase (serum ALT), control group [IU/L] time: 2h 8h 24h

inbred

16

m

7wks

N=3

2010

Rusyn2

36117

metabolic panel

trichloroethylene

alanine transaminase (serum ALT), treated group [IU/L] time: 2h 8h 24h

inbred

16

m

7wks

N=3

2010

Rusyn2

36122

metabolic panel

trichloroethylene

aspartate transaminase (serum AST), control group [IU/L] time: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

36127

metabolic panel

trichloroethylene

aspartate transaminase (serum AST), treated group [IU/L] time: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

36132

metabolic panel

trichloroethylene

blood urea nitrogen (serum BUN), control group [mg/dL] time: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

36137

metabolic panel

trichloroethylene

blood urea nitrogen (serum BUN), treated group [mg/dL] time: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

36167

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] time after treatment: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

36175

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (serum TCA) [nmol/mL] time after treatment: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

36185

drug and metabolite quantification

trichloroethylene

DCV cysteine (serum DCVC x 10^-3) [nmol/mL] time after treatment: 2h 8h 24h

inbred

15

m

7wks

N=2

2010

Rusyn2

36195

drug and metabolite quantification

trichloroethylene

DCV glutathione (serum DCVG x 10^-3) [nmol/mL] time after treatment: 2h 8h 24h

inbred

15

m

7wks

N=2

2010

Rusyn6

51202

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (serum TCA) [nmol/mL] TCA_serum_tce

inbred

7

m

6-7wks

N=3

2014

Rusyn6

51204

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (serum DCA) [nmol/mL] DCA_serum_tce

inbred

7

m

6-7wks

N=3

2014

Rusyn6

51206

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl) glutathione (serum DCVG) [pmol/mL] DCVG_serum_tce

inbred

4

m

6-7wks

N=2

2014

Rusyn6

51208

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl)-L-cysteine (serum DCVC) [pmol/mL] DCVC_serum_tce

inbred

7

m

6-7wks

N=3

2014

Rusyn6

51209

metabolic panel

trichloroethylene

blood urea nitrogen (serum BUN) [mg/dL] control TCE

inbred

7

m

6-7wks

N=4

2014

Rusyn6

51211

organ weights

trichloroethylene

liver weight as a percent of body weight [%] control TCE

inbred

7

m

6-7wks

N=4

2014

Rusyn6

51214

histopathology

trichloroethylene

BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group [%] BrdU_liver_tce

inbred

7

m

6-7wks

N=3

2014

Rusyn6

51216

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (liver TCA) [nmol/g] TCA_liver_tce

inbred

7

m

6-7wks

N=4

2014

Rusyn6

51218

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (liver DCA) [nmol/g] DCA_liver_tce

inbred

7

m

6-7wks

N=4

2014

Rusyn6

51220

drug and metabolite quantification

trichloroethylene

trichloroethanol (liver TCOH) [nmol/g] TCOH_liver_tce

inbred

7

m

6-7wks

N=4

2014

Rusyn6

51222

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl) glutathione (liver DCVG) [pmol/g] DCVG_liver_tce

inbred

7

m

6-7wks

N=4

2014

Rusyn6

51226

RNA expression profiling

trichloroethylene

Acox1, mRNA in liver, relative to control group [ratio] Acox1_liver_tce

inbred

7

m

6-7wks

N=3

2014

Rusyn6

51228

RNA expression profiling

trichloroethylene

Cyp4a10, mRNA in liver, relative to control group [ratio] Cyp4a10_liver_tce

inbred

7

m

6-7wks

N=3

2014

Rusyn6

51230

RNA expression profiling

trichloroethylene

Ppara, mRNA in liver, relative to control group [ratio] Ppara_liver_tce

inbred

7

m

6-7wks

N=3

2014

Rusyn6

51251

organ weights

trichloroethylene

kidney weight as a percent of body weight [%] control TCE

inbred

7

m

6-7wks

N=4

2014

Rusyn6

51254

histopathology

trichloroethylene

BrdU-positive nuclei in kidney (proximal tubule cell proliferation), relative to control group [%] BrdU_kidney_tce

inbred

7

m

6-7wks

N=3

2014

Rusyn6

51255

histopathology

trichloroethylene

kidney injury molecule 1 (KIM-1) positive proximal tubules [%] control TCE

inbred

7

m

6-7wks

N=4

2014

Rusyn6

51258

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (kidney TCA) [nmol/g] TCA_kidney_tce

inbred

7

m

6-7wks

N=4

2014

Rusyn6

51260

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (kidney DCA) [nmol/g] DCA_kidney_tce

inbred

6

m

6-7wks

N=3

2014

Rusyn6

51262

drug and metabolite quantification

trichloroethylene

trichloroethanol (kidney TCOH) [nmol/g] TCOH_kidney_tce

inbred

7

m

6-7wks

N=4

2014

Rusyn6

51264

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl) glutathione (kidney DCVG) [pmol/g] DCVG_kidney_tce

inbred

6

m

6-7wks

N=2

2014

Rusyn6

51266

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl)-L-cysteine (kidney DCVC) [pmol/g] DCVC_kidney_tce

inbred

6

m

6-7wks

N=2

2014

Rusyn6

51268

RNA expression profiling

trichloroethylene

Acox1, mRNA in kidney, relative to control group [ratio] Acox1_kidney_tce

inbred

7

m

6-7wks

N=3

2014

Rusyn6

51270

RNA expression profiling

trichloroethylene

Cyp4a10, mRNA in kidney, relative to control group [ratio] Cyp4a10_kidney_tce

inbred

7

m

6-7wks

N=3

2014

Rusyn6

51272

RNA expression profiling

trichloroethylene

Ppara, mRNA in kidney, relative to control group [ratio] Ppara_kidney_tce

inbred

7

m

6-7wks

N=3

2014