MPD: Measures involving trichloroethylene

Sort/ Pick	Data set	Procedure / Protocol	Drug or Challenge	Phenotype Measure	Panel	No. of Strains	Sex	Age	Sample Size (Avg)	Year
Rusyn2:12	Rusyn2	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), control group [IU/L] ALT_ctrl 36112 time: 2h 8h 24h	inbred	16	m	7wks	N=3	2010

Rusyn2:17	Rusyn2	metabolic panel	trichloroethylene	alanine transaminase (serum ALT), treated group [IU/L] ALT_tce 36117 time: 2h 8h 24h	inbred	16	m	7wks	N=3	2010

Rusyn2:22	Rusyn2	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), control group [IU/L] AST_ctrl 36122 time: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2:27	Rusyn2	metabolic panel	trichloroethylene	aspartate transaminase (serum AST), treated group [IU/L] AST_tce 36127 time: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2:32	Rusyn2	metabolic panel	trichloroethylene	blood urea nitrogen (serum BUN), control group [mg/dL] BUN_ctrl 36132 time: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2:37	Rusyn2	metabolic panel	trichloroethylene	blood urea nitrogen (serum BUN), treated group [mg/dL] BUN_tce 36137 time: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2:67	Rusyn2	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] DCA_tce 36167 time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2:75	Rusyn2	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (serum TCA) [nmol/mL] TCA_tce 36175 time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=3	2010

Rusyn2:85	Rusyn2	drug and metabolite quantification	trichloroethylene	DCV cysteine (serum DCVC x 10^-3) [nmol/mL] DCV_cysteine_tce 36185 time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=2	2010

Rusyn2:95	Rusyn2	drug and metabolite quantification	trichloroethylene	DCV glutathione (serum DCVG x 10^-3) [nmol/mL] DCV_glutathione_tce 36195 time after treatment: 2h 8h 24h	inbred	15	m	7wks	N=2	2010

Rusyn6:2	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (serum TCA) [nmol/mL] TCA_serum_tce 51202	inbred	7	m	6-7wks	N=3	2014

Rusyn6:4	Rusyn6	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (serum DCA) [nmol/mL] DCA_serum_tce 51204	inbred	7	m	6-7wks	N=3	2014

Rusyn6:6	Rusyn6	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl) glutathione (serum DCVG) [pmol/mL] DCVG_serum_tce 51206	inbred	4	m	6-7wks	N=2	2014

Rusyn6:8	Rusyn6	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl)-L-cysteine (serum DCVC) [pmol/mL] DCVC_serum_tce 51208	inbred	7	m	6-7wks	N=3	2014

Rusyn6:9	Rusyn6	metabolic panel	trichloroethylene	blood urea nitrogen (serum BUN) [mg/dL] BUN 51209 control TCE	inbred	7	m	6-7wks	N=4	2014

Rusyn6:11	Rusyn6	organ weights	trichloroethylene	liver weight as a percent of body weight [%] liver_adj 51211 control TCE	inbred	7	m	6-7wks	N=4	2014

Rusyn6:14	Rusyn6	histopathology	trichloroethylene	BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group [%] BrdU_liver_tce 51214	inbred	7	m	6-7wks	N=3	2014

Rusyn6:16	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (liver TCA) [nmol/g] TCA_liver_tce 51216	inbred	7	m	6-7wks	N=4	2014

Rusyn6:18	Rusyn6	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (liver DCA) [nmol/g] DCA_liver_tce 51218	inbred	7	m	6-7wks	N=4	2014

Rusyn6:20	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroethanol (liver TCOH) [nmol/g] TCOH_liver_tce 51220	inbred	7	m	6-7wks	N=4	2014

Rusyn6:22	Rusyn6	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl) glutathione (liver DCVG) [pmol/g] DCVG_liver_tce 51222	inbred	7	m	6-7wks	N=4	2014

Rusyn6:26	Rusyn6	RNA expression profiling	trichloroethylene	Acox1, mRNA in liver, relative to control group [ratio] Acox1_liver_tce 51226	inbred	7	m	6-7wks	N=3	2014

Rusyn6:28	Rusyn6	RNA expression profiling	trichloroethylene	Cyp4a10, mRNA in liver, relative to control group [ratio] Cyp4a10_liver_tce 51228	inbred	7	m	6-7wks	N=3	2014

Rusyn6:30	Rusyn6	RNA expression profiling	trichloroethylene	Ppara, mRNA in liver, relative to control group [ratio] Ppara_liver_tce 51230	inbred	7	m	6-7wks	N=3	2014

Rusyn6:51	Rusyn6	organ weights	trichloroethylene	kidney weight as a percent of body weight [%] kidney_adj 51251 control TCE	inbred	7	m	6-7wks	N=4	2014

Rusyn6:54	Rusyn6	histopathology	trichloroethylene	BrdU-positive nuclei in kidney (proximal tubule cell proliferation), relative to control group [%] BrdU_kidney_tce 51254	inbred	7	m	6-7wks	N=3	2014

Rusyn6:55	Rusyn6	histopathology	trichloroethylene	kidney injury molecule 1 (KIM-1) positive proximal tubules [%] KIM1_kidney 51255 control TCE	inbred	7	m	6-7wks	N=4	2014

Rusyn6:58	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroacetic acid (kidney TCA) [nmol/g] TCA_kidney_tce 51258	inbred	7	m	6-7wks	N=4	2014

Rusyn6:60	Rusyn6	drug and metabolite quantification	trichloroethylene	dichloroacetic acid (kidney DCA) [nmol/g] DCA_kidney_tce 51260	inbred	6	m	6-7wks	N=3	2014

Rusyn6:62	Rusyn6	drug and metabolite quantification	trichloroethylene	trichloroethanol (kidney TCOH) [nmol/g] TCOH_kidney_tce 51262	inbred	7	m	6-7wks	N=4	2014

Rusyn6:64	Rusyn6	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl) glutathione (kidney DCVG) [pmol/g] DCVG_kidney_tce 51264	inbred	6	m	6-7wks	N=2	2014

Rusyn6:66	Rusyn6	drug and metabolite quantification	trichloroethylene	S-(1,2-dichlorovinyl)-L-cysteine (kidney DCVC) [pmol/g] DCVC_kidney_tce 51266	inbred	6	m	6-7wks	N=2	2014

Rusyn6:68	Rusyn6	RNA expression profiling	trichloroethylene	Acox1, mRNA in kidney, relative to control group [ratio] Acox1_kidney_tce 51268	inbred	7	m	6-7wks	N=3	2014

Rusyn6:70	Rusyn6	RNA expression profiling	trichloroethylene	Cyp4a10, mRNA in kidney, relative to control group [ratio] Cyp4a10_kidney_tce 51270	inbred	7	m	6-7wks	N=3	2014

Rusyn6:72	Rusyn6	RNA expression profiling	trichloroethylene	Ppara, mRNA in kidney, relative to control group [ratio] Ppara_kidney_tce 51272	inbred	7	m	6-7wks	N=3	2014

Rusyn2

metabolic panel

trichloroethylene

alanine transaminase (serum ALT), control group [IU/L] ALT_ctrl 36112 time: 2h 8h 24h

inbred

16

m

7wks

N=3

2010

Rusyn2

metabolic panel

trichloroethylene

alanine transaminase (serum ALT), treated group [IU/L] ALT_tce 36117 time: 2h 8h 24h

inbred

16

m

7wks

N=3

2010

Rusyn2

metabolic panel

trichloroethylene

aspartate transaminase (serum AST), control group [IU/L] AST_ctrl 36122 time: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

metabolic panel

trichloroethylene

aspartate transaminase (serum AST), treated group [IU/L] AST_tce 36127 time: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

metabolic panel

trichloroethylene

blood urea nitrogen (serum BUN), control group [mg/dL] BUN_ctrl 36132 time: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

metabolic panel

trichloroethylene

blood urea nitrogen (serum BUN), treated group [mg/dL] BUN_tce 36137 time: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (serum DCA x 10^-3) [nmol/mL] DCA_tce 36167 time after treatment: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (serum TCA) [nmol/mL] TCA_tce 36175 time after treatment: 2h 8h 24h

inbred

15

m

7wks

N=3

2010

Rusyn2

drug and metabolite quantification

trichloroethylene

DCV cysteine (serum DCVC x 10^-3) [nmol/mL] DCV_cysteine_tce 36185 time after treatment: 2h 8h 24h

inbred

15

m

7wks

N=2

2010

Rusyn2

drug and metabolite quantification

trichloroethylene

DCV glutathione (serum DCVG x 10^-3) [nmol/mL] DCV_glutathione_tce 36195 time after treatment: 2h 8h 24h

inbred

15

m

7wks

N=2

2010

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (serum TCA) [nmol/mL] TCA_serum_tce 51202

inbred

7

m

6-7wks

N=3

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (serum DCA) [nmol/mL] DCA_serum_tce 51204

inbred

7

m

6-7wks

N=3

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl) glutathione (serum DCVG) [pmol/mL] DCVG_serum_tce 51206

inbred

4

m

6-7wks

N=2

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl)-L-cysteine (serum DCVC) [pmol/mL] DCVC_serum_tce 51208

inbred

7

m

6-7wks

N=3

2014

Rusyn6

metabolic panel

trichloroethylene

blood urea nitrogen (serum BUN) [mg/dL] BUN 51209 control TCE

inbred

7

m

6-7wks

N=4

2014

Rusyn6

organ weights

trichloroethylene

liver weight as a percent of body weight [%] liver_adj 51211 control TCE

inbred

7

m

6-7wks

N=4

2014

Rusyn6

histopathology

trichloroethylene

BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group [%] BrdU_liver_tce 51214

inbred

7

m

6-7wks

N=3

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (liver TCA) [nmol/g] TCA_liver_tce 51216

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (liver DCA) [nmol/g] DCA_liver_tce 51218

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroethanol (liver TCOH) [nmol/g] TCOH_liver_tce 51220

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl) glutathione (liver DCVG) [pmol/g] DCVG_liver_tce 51222

inbred

7

m

6-7wks

N=4

2014

Rusyn6

RNA expression profiling

trichloroethylene

Acox1, mRNA in liver, relative to control group [ratio] Acox1_liver_tce 51226

inbred

7

m

6-7wks

N=3

2014

Rusyn6

RNA expression profiling

trichloroethylene

Cyp4a10, mRNA in liver, relative to control group [ratio] Cyp4a10_liver_tce 51228

inbred

7

m

6-7wks

N=3

2014

Rusyn6

RNA expression profiling

trichloroethylene

Ppara, mRNA in liver, relative to control group [ratio] Ppara_liver_tce 51230

inbred

7

m

6-7wks

N=3

2014

Rusyn6

organ weights

trichloroethylene

kidney weight as a percent of body weight [%] kidney_adj 51251 control TCE

inbred

7

m

6-7wks

N=4

2014

Rusyn6

histopathology

trichloroethylene

BrdU-positive nuclei in kidney (proximal tubule cell proliferation), relative to control group [%] BrdU_kidney_tce 51254

inbred

7

m

6-7wks

N=3

2014

Rusyn6

histopathology

trichloroethylene

kidney injury molecule 1 (KIM-1) positive proximal tubules [%] KIM1_kidney 51255 control TCE

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroacetic acid (kidney TCA) [nmol/g] TCA_kidney_tce 51258

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

dichloroacetic acid (kidney DCA) [nmol/g] DCA_kidney_tce 51260

inbred

6

m

6-7wks

N=3

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

trichloroethanol (kidney TCOH) [nmol/g] TCOH_kidney_tce 51262

inbred

7

m

6-7wks

N=4

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl) glutathione (kidney DCVG) [pmol/g] DCVG_kidney_tce 51264

inbred

6

m

6-7wks

N=2

2014

Rusyn6

drug and metabolite quantification

trichloroethylene

S-(1,2-dichlorovinyl)-L-cysteine (kidney DCVC) [pmol/g] DCVC_kidney_tce 51266

inbred

6

m

6-7wks

N=2

2014

Rusyn6

RNA expression profiling

trichloroethylene

Acox1, mRNA in kidney, relative to control group [ratio] Acox1_kidney_tce 51268

inbred

7

m

6-7wks

N=3

2014

Rusyn6

RNA expression profiling

trichloroethylene

Cyp4a10, mRNA in kidney, relative to control group [ratio] Cyp4a10_kidney_tce 51270

inbred

7

m

6-7wks

N=3

2014

Rusyn6

RNA expression profiling

trichloroethylene

Ppara, mRNA in kidney, relative to control group [ratio] Ppara_kidney_tce 51272

inbred

7

m

6-7wks

N=3

2014

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