Intervention:   trichloroethylene          

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg) Year
    Rusyn2 36112 metabolic panel trichloroethylene alanine transaminase (serum ALT), control group   [IU/L]     control group:    2h    8h    24h inbred 16 m 7wks N=3 2010
    Rusyn2 36117 metabolic panel trichloroethylene alanine transaminase (serum ALT), treated group   [IU/L]     treated group:    2h    8h    24h inbred 16 m 7wks N=3 2010
    Rusyn2 36122 metabolic panel trichloroethylene aspartate transaminase (serum AST), control group   [IU/L]     control group:    2h    8h    24h inbred 15 m 7wks N=3 2010
    Rusyn2 36127 metabolic panel trichloroethylene aspartate transaminase (serum AST), treated group   [IU/L]     treated group:    2h    8h    24h inbred 15 m 7wks N=3 2010
    Rusyn2 36132 metabolic panel trichloroethylene blood urea nitrogen (serum BUN), control group   [mg/dL]     control group:    2h    8h    24h inbred 15 m 7wks N=3 2010
    Rusyn2 36137 metabolic panel trichloroethylene blood urea nitrogen (serum BUN), treated group   [mg/dL]     treated group:    2h    8h    24h inbred 15 m 7wks N=3 2010
    Rusyn2 36167 drug and metabolite quantification trichloroethylene dichloroacetic acid (serum DCA x 10-3)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=3 2010
    Rusyn2 36175 drug and metabolite quantification trichloroethylene trichloroacetic acid (serum TCA)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=3 2010
    Rusyn2 36185 drug and metabolite quantification trichloroethylene DCV cysteine (serum DCVC x 10-3)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=2 2010
    Rusyn2 36195 drug and metabolite quantification trichloroethylene DCV glutathione (serum DCVG x 10-3)   [nmol/mL]     treated group:    2h    8h    24h inbred 15 m 7wks N=2 2010
    Rusyn6 51202 drug and metabolite quantification trichloroethylene trichloroacetic acid (serum TCA)   [nmol/mL]  TCA_serum_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51204 drug and metabolite quantification trichloroethylene dichloroacetic acid (serum DCA)   [nmol/mL]  DCA_serum_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51206 drug and metabolite quantification trichloroethylene S-(1,2-dichlorovinyl) glutathione (serum DCVG)   [pmol/mL]  DCVG_serum_tce inbred 4 m 6-7wks N=2 2014
    Rusyn6 51208 drug and metabolite quantification trichloroethylene S-(1,2-dichlorovinyl)-L-cysteine (serum DCVC)   [pmol/mL]  DCVC_serum_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51209 metabolic panel trichloroethylene blood urea nitrogen (serum BUN)   [mg/dL]     control    TCE inbred 7 m 6-7wks N=4 2014
    Rusyn6 51211 organ weights trichloroethylene liver weight as a percent of body weight   [%]     control    TCE inbred 7 m 6-7wks N=4 2014
    Rusyn6 51214 histopathology trichloroethylene BrdU-positive nuclei in liver (hepatocellular proliferation), relative to control group   [%]  BrdU_liver_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51216 drug and metabolite quantification trichloroethylene trichloroacetic acid (liver TCA)   [nmol/g]  TCA_liver_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51218 drug and metabolite quantification trichloroethylene dichloroacetic acid (liver DCA)   [nmol/g]  DCA_liver_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51220 drug and metabolite quantification trichloroethylene trichloroethanol (liver TCOH)   [nmol/g]  TCOH_liver_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51222 drug and metabolite quantification trichloroethylene S-(1,2-dichlorovinyl) glutathione (liver DCVG)   [pmol/g]  DCVG_liver_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51226 RNA expression profiling trichloroethylene Acox1, mRNA in liver, relative to control group   [ratio]  Acox1_liver_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51228 RNA expression profiling trichloroethylene Cyp4a10, mRNA in liver, relative to control group   [ratio]  Cyp4a10_liver_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51230 RNA expression profiling trichloroethylene Ppara, mRNA in liver, relative to control group   [ratio]  Ppara_liver_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51251 organ weights trichloroethylene kidney weight as a percent of body weight   [%]     control    TCE inbred 7 m 6-7wks N=4 2014
    Rusyn6 51254 histopathology trichloroethylene BrdU-positive nuclei in kidney (proximal tubule cell proliferation), relative to control group   [%]  BrdU_kidney_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51255 histopathology trichloroethylene kidney injury molecule 1 (KIM-1) positive proximal tubules   [%]     control    TCE inbred 7 m 6-7wks N=4 2014
    Rusyn6 51258 drug and metabolite quantification trichloroethylene trichloroacetic acid (kidney TCA)   [nmol/g]  TCA_kidney_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51260 drug and metabolite quantification trichloroethylene dichloroacetic acid (kidney DCA)   [nmol/g]  DCA_kidney_tce inbred 6 m 6-7wks N=3 2014
    Rusyn6 51262 drug and metabolite quantification trichloroethylene trichloroethanol (kidney TCOH)   [nmol/g]  TCOH_kidney_tce inbred 7 m 6-7wks N=4 2014
    Rusyn6 51264 drug and metabolite quantification trichloroethylene S-(1,2-dichlorovinyl) glutathione (kidney DCVG)   [pmol/g]  DCVG_kidney_tce inbred 6 m 6-7wks N=3 2014
    Rusyn6 51266 drug and metabolite quantification trichloroethylene S-(1,2-dichlorovinyl)-L-cysteine (kidney DCVC)   [pmol/g]  DCVC_kidney_tce inbred 6 m 6-7wks N=3 2014
    Rusyn6 51268 RNA expression profiling trichloroethylene Acox1, mRNA in kidney, relative to control group   [ratio]  Acox1_kidney_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51270 RNA expression profiling trichloroethylene Cyp4a10, mRNA in kidney, relative to control group   [ratio]  Cyp4a10_kidney_tce inbred 7 m 6-7wks N=3 2014
    Rusyn6 51272 RNA expression profiling trichloroethylene Ppara, mRNA in kidney, relative to control group   [ratio]  Ppara_kidney_tce inbred 7 m 6-7wks N=3 2014
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Other available data sets:
Data set Procedure What's in this data set Strains
Tested
Sex Age Year
Rusyn8 study archive
with trichloroethylene
Trichloroethylene exposure. None None CC  (45) m 2017