MPD: Data set: Kliethermes1

Kliethermes CL, Crabbe JC. Genetic independence of mouse measures of some aspects of novelty seeking. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5018-23. Epub 2006 Mar 21. PubMed 16551746 FullText

High novelty seeking is correlated with risk for substance abuse. Mice were tested serially through the following five tests to assess novelty seeking: activity in a novel environment, novel environment preference, head dipping on a hole board, object preference on a hole board, and spontaneous alternation in a Y-maze.

Procedures conducted:

• monitoring system		Activity in a novel environment. Distance traveled, number of rears. 30 min test.
• two chamber assay		Novel environment preference. Activity in familiar and novel compartments. 20 min test.
• hole board test		Head dipping and other activity measures, hole board with and without objects in two of the holes. 10 min test.
• Y-maze		Spontaneous alternation.

Kliethermes1 downloads
• Download Kliethermes1 project data set animal data, as uploaded
• Download Kliethermes1 animal data matrix with factor-related expansion applied as necessary
• Download Kliethermes1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Kliethermes1 measures:

MP:0000436 abnormal head movements
MP:0001392 abnormal locomotor behavior
MP:0003107 abnormal response to novelty
MP:0003461 abnormal response to novel object
MP:0013189 abnormal exploration in a new environment
VT:0001392 locomotor behavior trait
VT:0010459 behavioral response to novel environment trait
VT:0010471 exploratory behavior trait
VT:0010709 behavioral response to novel object trait
VT:0010732 head movement trait

Investigators	Christopher L Kliethermes Drake University, Des Moines, IA John C Crabbe Oregon Health & Science University, Portland, OR
Contact	Christopher L Kliethermes christopher.kliethermes@drake.edu Lab web site
Acknowledgements	Funding provided by NIH AA10760, AA015015, AA13519, AA12714; US Department of Veterans Affairs
Project type	Phenotype strain survey data set
MPD identifiers	Kliethermes1 MPD:599
Data changelog	No updates/corrections. Initial release date: 08/2017.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Kliethermes1:1	Kliethermes1	monitoring system	(none)	distance traveled in a task to assess novelty seeking, 30 min test [cm] distance_MS 59901	inbred	14	both	8wks	N=6

Kliethermes1:2	Kliethermes1	monitoring system	(none)	number of rears in a task to assess novelty seeking, 30 min test [n] num_rears_MS 59902	inbred	14	both	8wks	N=6

Kliethermes1:3	Kliethermes1	monitoring system	(none)	time spent rearing in a task to assess novelty seeking, 30 min test [s] time_rears_MS 59903	inbred	14	both	8wks	N=6

Kliethermes1:4	Kliethermes1	monitoring system	(none)	residual score from regression of rears on horizontal activity in a task to assess novelty seeking, 30 min test [score] regression_MS 59904	inbred	14	both	8wks	N=6

Kliethermes1:11	Kliethermes1	two chamber assay	(none)	activity (beam breaks) in familiar compartment of novelty preference apparatus prior to preference test [n] activity_fam_prior_NP 59911	inbred	14	both	8wks	N=6

Kliethermes1:12	Kliethermes1	two chamber assay	(none)	activity (beam breaks) in familiar compartment of novelty preference apparatus, 20 min test [n] activity_fam_NP 59912	inbred	14	both	8wks	N=6

Kliethermes1:13	Kliethermes1	two chamber assay	(none)	activity (beam breaks) in novel compartment of novelty preference apparatus, 20 min test [n] activity_novel_NP 59913	inbred	14	both	8wks	N=6

Kliethermes1:16	Kliethermes1	two chamber assay	(none)	time spent in novel compartment of novelty preference apparatus, 20 min test [s] time_novel_NP 59916	inbred	14	both	8wks	N=6

Kliethermes1:17	Kliethermes1	two chamber assay	(none)	total activity (beam breaks) in novelty preference apparatus, 20 min test [n] tot_activity_NP 59917	inbred	14	both	8wks	N=6

Kliethermes1:18	Kliethermes1	two chamber assay	(none)	number of transitions between novel and familiar compartments in novelty preference apparatus, 20 min test [n] transitions_NP 59918	inbred	8	both	8wks	N=6

Kliethermes1:19	Kliethermes1	two chamber assay	(none)	residual score from regression of time spent in novel compartment on total activity in novelty preference apparatus, 20 min test [score] regression_time_NP 59919	inbred	14	both	8wks	N=6

Kliethermes1:20	Kliethermes1	two chamber assay	(none)	residual score from regression of activity in novel compartment on total activity in novelty preference apparatus, 20 min test [score] regression_activity_NP 59920	inbred	14	both	8wks	N=6

Kliethermes1:31	Kliethermes1	hole board test	(none)	distance traveled in head dip task to assess novelty seeking, 10 min test [cm] distance_HD 59931	inbred	14	both	8wks	N=6

Kliethermes1:32	Kliethermes1	hole board test	(none)	activity (beam breaks) in head dip task to assess novelty seeking, 10 min test [n] activity_HD 59932	inbred	14	both	8wks	N=6

Kliethermes1:33	Kliethermes1	hole board test	(none)	number of head dips in head dip task to assess novelty seeking, 10 min test [n] dips_HD 59933	inbred	14	both	8wks	N=6

Kliethermes1:34	Kliethermes1	hole board test	(none)	time spent head dipping in head dip task to assess novelty seeking, 10 min test [s] time_HD 59934	inbred	14	both	8wks	N=6

Kliethermes1:37	Kliethermes1	hole board test	(none)	residual score from regression of head dip count on horizontal activity in head dip task to assess novelty seeking, 10 min test [score] regression_HD 59937	inbred	14	both	8wks	N=6

Kliethermes1:38	Kliethermes1	hole board test	(none)	distance traveled in object preference task to assess novelty seeking, 10 min test [cm] distance_OP 59938	inbred	14	both	8wks	N=6

Kliethermes1:39	Kliethermes1	hole board test	(none)	activity (beam breaks) in object preference task to assess novelty seeking, 10 min test [n] activity_OP 59939	inbred	14	both	8wks	N=6

Kliethermes1:40	Kliethermes1	hole board test	(none)	number of head dips in object preference task to assess novelty seeking, 10 min test [n] dips_OP 59940	inbred	14	both	8wks	N=6

Kliethermes1:41	Kliethermes1	hole board test	(none)	time spent head dipping in object preference task to assess novelty seeking, 10 min test [s] time_OP 59941	inbred	14	both	8wks	N=6

Kliethermes1:42	Kliethermes1	hole board test	(none)	percentage of time spent head dipping during object preference task to assess novelty seeking, 10 min test [%] pct_time_OP 59942	inbred	14	both	8wks	N=6

Kliethermes1:43	Kliethermes1	hole board test	(none)	percentage of counts of head dipping at holes with objects during object preference task to assess novelty seeking, 10 min test [%] pct_num_OP 59943	inbred	14	both	8wks	N=6

Kliethermes1:44	Kliethermes1	hole board test	(none)	residual score from regression of object preference (count) on horizontal activity in object preference task to assess novelty seeking, 10 min test [score] regression_OP 59944	inbred	14	both	8wks	N=6

Kliethermes1:51	Kliethermes1	Y-maze	(none)	alternations during spontaneous alternation task to assess novelty seeking (0=same arm, 1=alternate arm) [n] alternation_Y 59951	inbred	14	both	8wks	N=6

Kliethermes1: Novelty seeking behavior in 14 inbred strains of mice (2006)