Kliethermes1: Novelty seeking behavior in 14 inbred strains of mice (2006)

Kliethermes CL, Crabbe JC. Genetic independence of mouse measures of some aspects of novelty seeking. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5018-23. Epub 2006 Mar 21.   PubMed 16551746     FullText


       
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Participants Christopher L Kliethermes       Drake University Des Moines, IA
John C Crabbe       Oregon Health & Science University Portland, OR
ContactChristopher L Kliethermes     christopher.kliethermes@drake.edu     Lab web site
AcknowledgementsFunding provided by NIH AA10760, AA015015, AA13519, AA12714; US Department of Veterans Affairs
Project type Phenotype strain survey data set
MPD identifiersKliethermes1     MPD:599
Data changelog No updates/corrections.       Initial release date: 08/2017.
Formatted citation
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High novelty seeking is correlated with risk for substance abuse. Mice were tested serially through the following five tests to assess novelty seeking: activity in a novel environment, novel environment preference, head dipping on a hole board, object preference on a hole board, and spontaneous alternation in a Y-maze.

Summary of procedures that were conducted
• monitoring system Activity in a novel environment. Distance traveled, number of rears. 30 min test.
• two chamber assay Novel environment preference. Activity in familiar and novel compartments. 20 min test.
• hole board test Head dipping and other activity measures, on hole board and with objects in two of the holes. 10 min test.
• Y-maze Spontaneous alternation.
Mice: inbred   14 strains   ♀♂   age 8wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Kliethermes1 59901 monitoring system (none) distance traveled in a task to assess novelty seeking, 30 min test   [cm]  distance_MS inbred 14 both 8wks N=6
    Kliethermes1 59902 monitoring system (none) number of rears in a task to assess novelty seeking, 30 min test   [n]  num_rears_MS inbred 14 both 8wks N=6
    Kliethermes1 59903 monitoring system (none) time spent rearing in a task to assess novelty seeking, 30 min test   [s]  time_rears_MS inbred 14 both 8wks N=6
    Kliethermes1 59904 monitoring system (none) residual score from regression of rears on horizontal activity in a task to assess novelty seeking, 30 min test   [score]  regression_MS inbred 14 both 8wks N=6
    Kliethermes1 59911 two chamber assay (none) activity (beam breaks) in familiar compartment of novelty preference apparatus prior to preference test   [n]  activity_fam_prior_NP inbred 14 both 8wks N=6
    Kliethermes1 59912 two chamber assay (none) activity (beam breaks) in familiar compartment of novelty preference apparatus, 20 min test   [n]  activity_fam_NP inbred 14 both 8wks N=6
    Kliethermes1 59913 two chamber assay (none) activity (beam breaks) in novel compartment of novelty preference apparatus, 20 min test   [n]  activity_novel_NP inbred 14 both 8wks N=6
    Kliethermes1 59916 two chamber assay (none) time spent in novel compartment of novelty preference apparatus, 20 min test   [s]  time_novel_NP inbred 14 both 8wks N=6
    Kliethermes1 59917 two chamber assay (none) total activity (beam breaks) in novelty preference apparatus, 20 min test   [n]  tot_activity_NP inbred 14 both 8wks N=6
    Kliethermes1 59918 two chamber assay (none) number of transitions between novel and familiar compartments in novelty preference apparatus, 20 min test   [n]  transitions_NP inbred 8 both 8wks N=6
    Kliethermes1 59919 two chamber assay (none) residual score from regression of time spent in novel compartment on total activity in novelty preference apparatus, 20 min test   [score]  regression_time_NP inbred 14 both 8wks N=6
    Kliethermes1 59920 two chamber assay (none) residual score from regression of activity in novel compartment on total activity in novelty preference apparatus, 20 min test   [score]  regression_activity_NP inbred 14 both 8wks N=6
    Kliethermes1 59931 hole board test (none) distance traveled in head dip task to assess novelty seeking, 10 min test   [cm]  distance_HD inbred 14 both 8wks N=6
    Kliethermes1 59932 hole board test (none) activity (beam breaks) in head dip task to assess novelty seeking, 10 min test   [n]  activity_HD inbred 14 both 8wks N=6
    Kliethermes1 59933 hole board test (none) number of head dips in head dip task to assess novelty seeking, 10 min test   [n]  dips_HD inbred 14 both 8wks N=6
    Kliethermes1 59934 hole board test (none) time spent head dipping in head dip task to assess novelty seeking, 10 min test   [s]  time_HD inbred 14 both 8wks N=6
    Kliethermes1 59937 hole board test (none) residual score from regression of head dip count on horizontal activity in head dip task to assess novelty seeking, 10 min test   [score]  regression_HD inbred 14 both 8wks N=6
    Kliethermes1 59938 hole board test (none) distance traveled in object preference task to assess novelty seeking, 10 min test   [cm]  distance_OP inbred 14 both 8wks N=6
    Kliethermes1 59939 hole board test (none) activity (beam breaks) in object preference task to assess novelty seeking, 10 min test   [n]  activity_OP inbred 14 both 8wks N=7
    Kliethermes1 59940 hole board test (none) number of head dips in object preference task to assess novelty seeking, 10 min test   [n]  dips_OP inbred 14 both 8wks N=6
    Kliethermes1 59941 hole board test (none) time spent head dipping in object preference task to assess novelty seeking, 10 min test   [s]  time_OP inbred 14 both 8wks N=6
    Kliethermes1 59942 hole board test (none) percentage of time spent head dipping during object preference task to assess novelty seeking, 10 min test   [%]  pct_time_OP inbred 14 both 8wks N=6
    Kliethermes1 59943 hole board test (none) percentage of counts of head dipping at holes with objects during object preference task to assess novelty seeking, 10 min test   [%]  pct_num_OP inbred 14 both 8wks N=6
    Kliethermes1 59944 hole board test (none) residual score from regression of object preference (count) on horizontal activity in object preference task to assess novelty seeking, 10 min test   [score]  regression_OP inbred 14 both 8wks N=6
    Kliethermes1 59951 Y-maze (none) alternations during spontaneous alternation task to assess novelty seeking (0=same arm, 1=alternate arm)   [n]  alternation_Y inbred 14 both 8wks N=6
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