Kliethermes1: Novelty seeking behavior in 14 inbred strains of mice (2006)

Kliethermes CL, Crabbe JC. Genetic independence of mouse measures of some aspects of novelty seeking. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5018-23. Epub 2006 Mar 21.   PubMed 16551746     FullText


         
High novelty seeking is correlated with risk for substance abuse. Mice were tested serially through the following five tests to assess novelty seeking: activity in a novel environment, novel environment preference, head dipping on a hole board, object preference on a hole board, and spontaneous alternation in a Y-maze.

Procedures conducted:
• monitoring system  Activity in a novel environment. Distance traveled, number of rears. 30 min test.
• two chamber assay  Novel environment preference. Activity in familiar and novel compartments. 20 min test.
• hole board test  Head dipping and other activity measures, hole board with and without objects in two of the holes. 10 min test.
• Y-maze  Spontaneous alternation.

Kliethermes1 downloads
• Download Kliethermes1 project data set     animal data, as uploaded
• Download Kliethermes1 animal data matrix     with factor-related expansion applied as necessary
• Download Kliethermes1 strain means, SD, N, etc.     one row per strain/sex/measure
Investigators Christopher L Kliethermes       Drake University,  Des Moines, IA
John C Crabbe       Oregon Health & Science University,  Portland, OR
ContactChristopher L Kliethermes     christopher.kliethermes@drake.edu     Lab web site
AcknowledgementsFunding provided by NIH AA10760, AA015015, AA13519, AA12714; US Department of Veterans Affairs
Project type Phenotype strain survey data set
MPD identifiersKliethermes1     MPD:599
Data changelog No updates/corrections.       Initial release date: 08/2017.
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Mice: inbred   14 strains   ♀♂   age 8wks   1 experimental group