Kliethermes1: Novelty seeking behavior in 14 inbred strains of mice (2006)

Kliethermes CL, Crabbe JC. Genetic independence of mouse measures of some aspects of novelty seeking. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5018-23. Epub 2006 Mar 21.   PubMed 16551746     FullText


       
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Participants Christopher L Kliethermes       Drake University Des Moines, IA
John C Crabbe       Oregon Health & Science University Portland, OR
ContactChristopher L Kliethermes     christopher.kliethermes@drake.edu     Lab web site
AcknowledgementsFunding provided by NIH AA10760, AA015015, AA13519, AA12714; US Department of Veterans Affairs
Project type Phenotype strain survey data set
MPD identifiersKliethermes1     MPD:599
Data changelog No updates/corrections.       Initial release date: 08/2017.
Formatted citation
Click above to copy-paste the entire citation for this MPD web page.
High novelty seeking is correlated with risk for substance abuse. Mice were tested serially through the following five tests to assess novelty seeking: activity in a novel environment, novel environment preference, head dipping on a hole board, object preference on a hole board, and spontaneous alternation in a Y-maze.

Summary of procedures that were conducted
• monitoring system Activity in a novel environment. Distance traveled, number of rears. 30 min test.
• two chamber assay Novel environment preference. Activity in familiar and novel compartments. 20 min test.
• hole board test Head dipping and other activity measures, hole board with and without objects in two of the holes. 10 min test.
• Y-maze Spontaneous alternation.
Mice: inbred   14 strains   ♀♂   age 8wks   1 cohort