MPD: Project measure / variable: Kliethermes1 activity_fam_prior

Project measure / variable: Kliethermes1 activity_fam_prior_NP

ID, description, units	MPD:59911 activity_fam_prior_NP activity (beam breaks) in familiar compartment of novelty preference apparatus prior to preference test [n]
Data set, strains	Kliethermes1 inbred 14 strains sex: both age: 8wks
Procedure	two chamber assay
Ontology mappings	MP:0001392 abnormal locomotor behavior MP:0003107 abnormal response to novelty MP:0013189 abnormal exploration in a new environment VT:0001392 locomotor behavior trait VT:0010459 behavioral response to novel environment trait VT:0010471 exploratory behavior trait

STRAIN COMPARISON PLOT

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Visualization Options Least squares means Alphabetical order Strains on X-axis Individual points

Kliethermes1 - activity (beam breaks) in familiar compartment of novelty preference apparatus prior to preference test

MEASURE SUMMARY

Measure Summary	Female	Male
Number of strains tested	14 strains	14 strains
Mean of the strain means	3318 n	3578 n
Median of the strain means	3212 n	3316 n
SD of the strain means	± 1640	± 1521
Coefficient of variation (CV)	0.494	0.425
Min–max range of strain means	1098 – 6829 n	1391 – 6260 n
Mean sample size per strain	6.3 mice	6.2 mice

ANOVA, Q-Q NORMALITY ASSESSMENT

ANOVA summary

Factor	DF	Sum of squares	Mean sum of squares	F value	p value (Pr>F)
sex	1	4278283.3941	4278283.3941	9.0213	0.0031
strain	13	392650040.972	30203849.3055	63.6887	< 0.0001
sex:strain	13	24748440.2157	1903726.1704	4.0143	< 0.0001
Residuals	157	74455970.0343	474241.8474

Q-Q normality assessment based on residuals

STRAIN MEANS (UNADJUSTED)

Strain	Sex	Mean	SD	N mice	SEM	CV	Min, Max	Z score
129S1/SvImJ	f	1238.0	753.0	6	307.0	0.608	478.0, 2600.0	-1.27
129S1/SvImJ	m	2627.0	886.0	6	362.0	0.337	1454.0, 3526.0	-0.63
A/J	f	1098.0	192.0	6	78.3	0.175	856.0, 1332.0	-1.35
A/J	m	1391.0	273.0	6	111.0	0.196	926.0, 1770.0	-1.44
AKR/J	f	3444.0	742.0	6	303.0	0.216	2364.0, 4220.0	0.08
AKR/J	m	3839.0	651.0	6	266.0	0.17	3096.0, 4736.0	0.17
BALB/cByJ	f	2922.0	885.0	5	396.0	0.303	1706.0, 3982.0	-0.24
BALB/cByJ	m	3406.0	908.0	6	371.0	0.267	2556.0, 4854.0	-0.11
BTBR T⁺ Itpr3^tf/J	f	3426.0	652.0	6	266.0	0.19	2960.0, 4706.0	0.07
BTBR T⁺ Itpr3^tf/J	m	3920.0	788.0	6	322.0	0.201	2620.0, 4724.0	0.22
C3H/HeJ	f	2380.0	250.0	6	102.0	0.105	2016.0, 2708.0	-0.57
C3H/HeJ	m	1995.0	161.0	6	65.7	0.0807	1774.0, 2180.0	-1.04
C57BL/6J	f	4964.0	539.0	11	162.0	0.108	4116.0, 5734.0	1.0
C57BL/6J	m	4725.0	1192.0	12	344.0	0.252	3206.0, 7692.0	0.75
C57L/J	f	5357.0	1106.0	6	452.0	0.206	3952.0, 7194.0	1.24
C57L/J	m	6260.0	674.0	6	275.0	0.108	5420.0, 6964.0	1.76
DBA/2J	f	2289.0	328.0	12	94.8	0.143	1706.0, 2756.0	-0.63
DBA/2J	m	3227.0	456.0	9	152.0	0.141	2584.0, 3936.0	-0.23
FVB/NJ	f	4479.0	569.0	6	232.0	0.127	3794.0, 5192.0	0.71
FVB/NJ	m	5061.0	443.0	6	181.0	0.0876	4468.0, 5662.0	0.97
NOD/ShiLtJ	f	6829.0	784.0	6	320.0	0.115	5656.0, 7736.0	2.14
NOD/ShiLtJ	m	6150.0	855.0	6	349.0	0.139	5152.0, 7548.0	1.69
NZB/BlNJ	f	1606.0	385.0	6	157.0	0.239	1072.0, 2008.0	-1.04
NZB/BlNJ	m	2656.0	543.0	6	222.0	0.204	1930.0, 3422.0	-0.61
PERA/EiJ	f	3416.0	642.0	5	287.0	0.188	2530.0, 4196.0	0.06
PERA/EiJ	m	1831.0	743.0	6	303.0	0.406	474.0, 2520.0	-1.15
PL/J	f	3009.0	381.0	6	155.0	0.126	2632.0, 3510.0	-0.19
PL/J	m	3006.0	849.0	5	380.0	0.282	2144.0, 4286.0	-0.38

LEAST SQUARES MEANS (MODEL-ADJUSTED)

Strain	Sex	Mean	SEM	UpperCL	LowerCL
129S1/SvImJ	f	1238.3333	281.1411	1793.6402	683.0265
129S1/SvImJ	m	2627.0	281.1411	3182.3068	2071.6932
A/J	f	1098.3333	281.1411	1653.6402	543.0265
A/J	m	1391.3333	281.1411	1946.6402	836.0265
AKR/J	f	3444.0	281.1411	3999.3068	2888.6932
AKR/J	m	3838.6667	281.1411	4393.9735	3283.3598
BALB/cByJ	f	2921.6	307.9746	3529.9081	2313.2919
BALB/cByJ	m	3405.6667	281.1411	3960.9735	2850.3598
BTBR T⁺ Itpr3^tf/J	f	3425.6667	281.1411	3980.9735	2870.3598
BTBR T⁺ Itpr3^tf/J	m	3920.3333	281.1411	4475.6402	3365.0265
C3H/HeJ	f	2379.6667	281.1411	2934.9735	1824.3598
C3H/HeJ	m	1995.0	281.1411	2550.3068	1439.6932
C57BL/6J	f	4964.3636	207.6364	5374.4849	4554.2424
C57BL/6J	m	4725.3333	198.7968	5117.9946	4332.6721
C57L/J	f	5356.6667	281.1411	5911.9735	4801.3598
C57L/J	m	6260.0	281.1411	6815.3068	5704.6932
DBA/2J	f	2289.1667	198.7968	2681.8279	1896.5054
DBA/2J	m	3226.8889	229.5507	3680.295	2773.4828
FVB/NJ	f	4478.6667	281.1411	5033.9735	3923.3598
FVB/NJ	m	5061.0	281.1411	5616.3068	4505.6932
NOD/ShiLtJ	f	6829.3333	281.1411	7384.6402	6274.0265
NOD/ShiLtJ	m	6150.3333	281.1411	6705.6402	5595.0265
NZB/BlNJ	f	1606.3333	281.1411	2161.6402	1051.0265
NZB/BlNJ	m	2656.0	281.1411	3211.3068	2100.6932
PERA/EiJ	f	3415.6	307.9746	4023.9081	2807.2919
PERA/EiJ	m	1831.0	281.1411	2386.3068	1275.6932
PL/J	f	3008.6667	281.1411	3563.9735	2453.3598
PL/J	m	3006.4	307.9746	3614.7081	2398.0919

LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED

Strain	Sex	Mean	SEM	UpperCL	LowerCL
129S1/SvImJ	both	1932.6667	198.7968	2325.3279	1540.0054
A/J	both	1244.8333	198.7968	1637.4946	852.1721
AKR/J	both	3641.3333	198.7968	4033.9946	3248.6721
BALB/cByJ	both	3163.6333	208.4998	3575.4599	2751.8068
BTBR T⁺ Itpr3^tf/J	both	3673.0	198.7968	4065.6612	3280.3388
C3H/HeJ	both	2187.3333	198.7968	2579.9946	1794.6721
C57BL/6J	both	4844.8485	143.7298	5128.7421	4560.9549
C57L/J	both	5808.3333	198.7968	6200.9946	5415.6721
DBA/2J	both	2758.0278	151.8335	3057.9277	2458.1278
FVB/NJ	both	4769.8333	198.7968	5162.4946	4377.1721
NOD/ShiLtJ	both	6489.8333	198.7968	6882.4946	6097.1721
NZB/BlNJ	both	2131.1667	198.7968	2523.8279	1738.5054
PERA/EiJ	both	2623.3	208.4998	3035.1266	2211.4734
PL/J	both	3007.5333	208.4998	3419.3599	2595.7068

INDIVIDUAL ANIMAL VALUES

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GWAS USING LINEAR MIXED MODELS