MPD: Data set: Donahue2

Animals were assessed using densitometer dual energy X-ray absorptiometry (DXA), material testing solutions (MTS) systems, and computed tomography (µCT 40 and pQCT).

Procedures conducted:

• body weight
• muscle weights		Quadriceps muscle.
• DXA		Femur bone mineral density and content, thigh cross sectional areas.
• bone dimensions		Femur.
• computed tomography		Bone morphology (femur).
• biomechanical test		Bone strength.

Donahue2 downloads
• Download Donahue2 project data set animal data, as uploaded
• Download Donahue2 animal data matrix with factor-related expansion applied as necessary
• Download Donahue2 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Donahue2 measures:

MA:0000663 hindlimb muscle
MA:0001359 femur
MA:0001459 bone
MA:0002363 quadriceps
MP:0000559 abnormal femur morphology
MP:0001259 abnormal body weight
MP:0001542 abnormal bone strength
MP:0004214 abnormal long bone diaphysis morphology
MP:0009458 abnormal skeletal muscle size
MP:0010119 abnormal bone mineral density
MP:0010122 abnormal bone mineral content
MP:0020164 abnormal quadriceps weight
VT:0001259 body mass
VT:0001542 bone strength trait
VT:0003398 skeletal muscle size trait
VT:0004348 femur length
VT:0005007 bone mineral mass
VT:0010569 quadriceps morphology trait
VT:1000369 femur size trait
VT:1000666 femur width

Investigators	Leah Rae Donahue The Jackson Laboratory, Bar Harbor, ME Wesley G Beamer The Jackson Laboratory, Bar Harbor, ME Molly A Bogue The Jackson Laboratory, Bar Harbor, ME Gary A Churchill The Jackson Laboratory, Bar Harbor, ME
Participants	Tsaih S-W, Sears AR, MacKenzie GW
Contact	Leah Rae Donahue lrd@jax.org Lab web site
Acknowledgements	Funding provided by NIH DE13078; Department of the Army Grant DAMD17-03-1-0773
Project type	Phenotype strain survey data set
MPD identifiers	Donahue2 MPD:172
Data changelog	No updates/corrections. Initial release date: 05/2008.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Donahue2:1	Donahue2	body weight	(none)	whole body weight, with head [g] bw 17201	inbred	10	both	16wks	N=10

Donahue2:2	Donahue2	DXA	(none)	volumetric bone mineral density (vBMD), whole left femur [g/cm³] femur_vBMD 17202	inbred	10	both	16wks	N=10

Donahue2:3	Donahue2	DXA	(none)	cortical shell volumetric bone mineral density (vBMD), whole left femur [g/cm³] femur_cortical_BMD 17203	inbred	10	both	16wks	N=10

Donahue2:4	Donahue2	DXA	(none)	cross sectional volumetric bone mineral density (vBMD), right femur mid-diaphysis [g/cm³] femur_shaft_BMD 17204	inbred	10	both	16wks	N=10

Donahue2:5	Donahue2	DXA	(none)	cross sectional bone mineral content (BMC), right femur mid-diaphysis [g] femur_shaft_BMC 17205	inbred	10	both	16wks	N=10

Donahue2:6	Donahue2	biomechanical test	(none)	maximum load on load-displacement curve [N] femur_peak_load 17206	inbred	10	both	16wks	N=10

Donahue2:7	Donahue2	biomechanical test	(none)	displacement at peak load [mm] femur_peak_extension 17207	inbred	10	both	16wks	N=10

Donahue2:8	Donahue2	biomechanical test	(none)	load at specimen failure (break point) [N] femur_break_load 17208	inbred	10	both	16wks	N=10

Donahue2:9	Donahue2	biomechanical test	(none)	load at 95% break load [N] femur_yield_load 17209	inbred	10	both	16wks	N=10

Donahue2:10	Donahue2	biomechanical test	(none)	area under load-displacement curve to break point [N⋅mm] femur_break_energy 17210	inbred	10	both	16wks	N=10

Donahue2:11	Donahue2	biomechanical test	(none)	area under load-displacement curve to peak load [N/mm²] femur_peak_energy 17211	inbred	10	both	16wks	N=10

Donahue2:12	Donahue2	biomechanical test	(none)	slope of force-displacement curve in linear region [N/mm] femur_stiffness 17212	inbred	10	both	16wks	N=10

Donahue2:13	Donahue2	bone dimensions	(none)	length of right femur, condyles to rostral tip of greater trochanter [mm] femur_length 17213	inbred	10	both	16wks	N=10

Donahue2:14	Donahue2	bone dimensions	(none)	anterior to posterior, rostral to caudal, width of right femur, mid-diaphysis [mm] femur_width_AP 17214	inbred	10	both	16wks	N=10

Donahue2:15	Donahue2	bone dimensions	(none)	medial to lateral width of right femur, mid-diaphysis [mm] femur_width_ML 17215	inbred	10	both	16wks	N=10

Donahue2:16	Donahue2	computed tomography	(none)	cross sectional bone area, whole thigh area minus muscle area, femoral mid-diaphysis [mm²] femur_area 17216	inbred	10	both	16wks	N=10

Donahue2:17	Donahue2	computed tomography	(none)	cortical thickness of right femur, pQCT [mm] femur_thickness_R1 17217	inbred	10	both	16wks	N=10

Donahue2:18	Donahue2	computed tomography	(none)	cortical thickness of right femur, µCT [mm] femur_thickness_R2 17218	inbred	10	both	16wks	N=10

Donahue2:19	Donahue2	computed tomography	(none)	cortical thickness of left femur, pQCT [mm] femur_thickness_L 17219	inbred	10	both	16wks	N=10

Donahue2:20	Donahue2	computed tomography	(none)	periosteal (outer) circumference, femoral mid-diaphysis [mm] femur_out 17220	inbred	10	both	16wks	N=10

Donahue2:21	Donahue2	computed tomography	(none)	endosteal (inner) circumference, femoral mid-diaphysis [mm] femur_in 17221	inbred	10	both	16wks	N=10

Donahue2:22	Donahue2	DXA	(none)	cross-sectional area of thigh muscle and bone, femoral mid-diaphysis [mm²] thigh_area 17222	inbred	10	both	16wks	N=10

Donahue2:23	Donahue2	DXA	(none)	cross-sectional thigh muscle area (thigh area minus femur area), femoral mid-diaphysis [mm²] thigh_muscle_area 17223	inbred	10	both	16wks	N=10

Donahue2:24	Donahue2	muscle weights	(none)	weight of isolated right quadriceps muscle [g] quadricep_wt 17224	inbred	10	both	16wks	N=10

Donahue2:30	Donahue2	biomechanical test	(none)	estimated elastic modulus [N/mm²] elastic_modulus 17230	inbred	10	both	16wks	N=10

Donahue2:31	Donahue2	biomechanical test	(none)	estimated ultimate strength [N] ultimate_strength 17231	inbred	10	both	16wks	N=10

Donahue2: Characterization of skeletal geometry and bone strength in 10 inbred strains of mice (2004)

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