Project measure / variable:   Donahue2   femur_thickness_R1

ID, description, units MPD:17217   femur_thickness_R1   cortical thickness of right femur, pQCT   [mm]  
Data set, strains Donahue2   inbred   10 strains     sex: both     age: 16wks
Procedure computed tomography
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  STRAIN COMPARISON PLOT
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Donahue2 - cortical thickness of right femur, pQCT



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means0.226   mm 0.239   mm
Median of the strain means0.218   mm 0.220   mm
SD of the strain means± 0.0392 ± 0.0449
Coefficient of variation (CV)0.174 0.188
Min–max range of strain means0.180   –   0.315   mm 0.191   –   0.340   mm
Mean sample size per strain10.0   mice 10.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0114 0.0114 33.2274 < 0.0001
strain 9 0.307 0.0341 99.7866 < 0.0001
sex:strain 9 0.0093 0.001 3.0338 0.0021
Residuals 191 0.0653 0.0003


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.225 0.0141   10 0.00447 0.0629 0.203, 0.25 -0.02
129S1/SvImJ m 0.251 0.036   15 0.00928 0.143 0.213, 0.356 0.27
BALB/cJ f 0.253 0.0149   10 0.00472 0.059 0.234, 0.275 0.69
BALB/cJ m 0.282 0.0175   10 0.00553 0.062 0.259, 0.312 0.96
C3H/HeJ f 0.315 0.0104   9 0.00345 0.0329 0.299, 0.325 2.27
C3H/HeJ m 0.34 0.0165   10 0.0052 0.0485 0.314, 0.365 2.25
C57BL/6J f 0.199 0.0108   10 0.00342 0.0543 0.183, 0.218 -0.69
C57BL/6J m 0.214 0.0114   12 0.0033 0.0533 0.193, 0.232 -0.55
C58/J f 0.21 0.0115   10 0.00365 0.0548 0.196, 0.228 -0.41
C58/J m 0.217 0.00944   10 0.00298 0.0435 0.203, 0.236 -0.49
FVB/NJ f 0.211 0.0117   11 0.00352 0.0552 0.194, 0.227 -0.38
FVB/NJ m 0.211 0.0129   9 0.00429 0.0611 0.189, 0.23 -0.62
NZB/BlNJ f 0.24 0.0117   11 0.00354 0.049 0.222, 0.255 0.36
NZB/BlNJ m 0.256 0.0233   13 0.00645 0.0908 0.215, 0.299 0.38
PWK/PhJ f 0.187 0.01   12 0.00289 0.0536 0.163, 0.202 -0.99
PWK/PhJ m 0.191 0.0259   11 0.00782 0.136 0.148, 0.224 -1.07
SJL/J f 0.239 0.0421   8 0.0149 0.176 0.204, 0.335 0.33
SJL/J m 0.222 0.00949   11 0.00286 0.0427 0.204, 0.238 -0.38
SWR/J f 0.18 0.00603   9 0.00201 0.0335 0.173, 0.19 -1.17
SWR/J m 0.205 0.00997   10 0.00315 0.0487 0.187, 0.216 -0.76


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.2246 0.0058 0.2361 0.2131
129S1/SvImJ m 0.2509 0.0048 0.2603 0.2415
BALB/cJ f 0.253 0.0058 0.2645 0.2415
BALB/cJ m 0.2818 0.0058 0.2933 0.2703
C3H/HeJ f 0.3147 0.0062 0.3268 0.3025
C3H/HeJ m 0.3397 0.0058 0.3512 0.3282
C57BL/6J f 0.1991 0.0058 0.2106 0.1876
C57BL/6J m 0.2143 0.0053 0.2249 0.2038
C58/J f 0.2103 0.0058 0.2218 0.1988
C58/J m 0.2168 0.0058 0.2283 0.2053
FVB/NJ f 0.2115 0.0056 0.2225 0.2005
FVB/NJ m 0.2108 0.0062 0.2229 0.1986
NZB/BlNJ f 0.2396 0.0056 0.2506 0.2286
NZB/BlNJ m 0.2561 0.0051 0.2662 0.246
PWK/PhJ f 0.1867 0.0053 0.1972 0.1761
PWK/PhJ m 0.1906 0.0056 0.2016 0.1796
SJL/J f 0.2389 0.0065 0.2518 0.226
SJL/J m 0.2225 0.0056 0.2335 0.2115
SWR/J f 0.1801 0.0062 0.1923 0.168
SWR/J m 0.2046 0.0058 0.2161 0.1931


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.2378 0.0038 0.2452 0.2303
BALB/cJ both 0.2674 0.0041 0.2756 0.2592
C3H/HeJ both 0.3272 0.0042 0.3356 0.3188
C57BL/6J both 0.2067 0.004 0.2145 0.1989
C58/J both 0.2135 0.0041 0.2217 0.2054
FVB/NJ both 0.2111 0.0042 0.2193 0.2029
NZB/BlNJ both 0.2479 0.0038 0.2553 0.2404
PWK/PhJ both 0.1887 0.0039 0.1963 0.181
SJL/J both 0.2307 0.0043 0.2391 0.2222
SWR/J both 0.1924 0.0042 0.2007 0.184




  GWAS USING LINEAR MIXED MODELS