Project measure / variable:   Donahue2   thigh_area

ID, description, units MPD:17222   thigh_area   cross-sectional area of thigh muscle and bone, femoral mid-diaphysis   [mm2]  
Data set, strains Donahue2   inbred   10 strains     sex: both     age: 16wks
Procedure DXA
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  STRAIN COMPARISON PLOT
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Donahue2 - cross-sectional area of thigh muscle and bone, femoral mid-diaphysis



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means64.8   mm2 79.0   mm2
Median of the strain means66.9   mm2 80.5   mm2
SD of the strain means± 9.28 ± 13.5
Coefficient of variation (CV)0.143 0.171
Min–max range of strain means46.2   –   78.3   mm2 49.5   –   99.3   mm2
Mean sample size per strain9.6   mice 10.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 10751.3546 10751.3546 121.0094 < 0.0001
strain 9 23962.2399 2662.4711 29.9668 < 0.0001
sex:strain 9 3126.6709 347.4079 3.9102 0.0001
Residuals 187 16614.4411 88.8473


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 65.4 6.42   10 2.03 0.0982 57.7, 75.2 0.06
129S1/SvImJ m 71.7 15.1   15 3.91 0.211 46.0, 90.5 -0.54
BALB/cJ f 67.6 8.05   10 2.54 0.119 55.7, 79.1 0.3
BALB/cJ m 84.1 7.53   10 2.38 0.0895 73.1, 97.0 0.38
C3H/HeJ f 71.1 7.78   9 2.59 0.11 60.2, 84.5 0.68
C3H/HeJ m 80.3 10.5   10 3.32 0.131 63.3, 95.5 0.1
C57BL/6J f 66.2 6.85   8 2.42 0.103 56.5, 76.9 0.15
C57BL/6J m 91.4 13.4   12 3.87 0.146 72.4, 115.0 0.92
C58/J f 56.7 3.8   10 1.2 0.0671 51.2, 64.8 -0.87
C58/J m 74.5 7.18   10 2.27 0.0964 60.6, 85.9 -0.33
FVB/NJ f 71.7 5.32   11 1.61 0.0742 65.3, 85.5 0.74
FVB/NJ m 86.5 9.55   9 3.18 0.11 66.1, 97.0 0.56
NZB/BlNJ f 78.3 7.14   10 2.26 0.0912 69.5, 94.0 1.45
NZB/BlNJ m 99.3 14.2   12 4.11 0.143 80.5, 127.0 1.5
PWK/PhJ f 46.2 6.24   12 1.8 0.135 37.3, 54.3 -2.0
PWK/PhJ m 49.5 9.91   11 2.99 0.2 35.3, 61.8 -2.18
SJL/J f 68.4 13.8   8 4.89 0.202 52.1, 94.6 0.39
SJL/J m 71.8 7.75   11 2.34 0.108 60.8, 84.2 -0.53
SWR/J f 56.4 6.23   9 2.08 0.111 48.4, 69.2 -0.91
SWR/J m 80.7 4.84   10 1.53 0.06 74.7, 88.7 0.13


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 65.39 2.9807 71.2702 59.5098
129S1/SvImJ m 71.6867 2.4338 76.4878 66.8855
BALB/cJ f 67.64 2.9807 73.5202 61.7598
BALB/cJ m 84.11 2.9807 89.9902 78.2298
C3H/HeJ f 71.0556 3.142 77.2538 64.8573
C3H/HeJ m 80.33 2.9807 86.2102 74.4498
C57BL/6J f 66.1875 3.3326 72.7617 59.6133
C57BL/6J m 91.4417 2.721 96.8095 86.0738
C58/J f 56.69 2.9807 62.5702 50.8098
C58/J m 74.49 2.9807 80.3702 68.6098
FVB/NJ f 71.7273 2.842 77.3338 66.1207
FVB/NJ m 86.4889 3.142 92.6871 80.2906
NZB/BlNJ f 78.28 2.9807 84.1602 72.3998
NZB/BlNJ m 99.3333 2.721 104.7012 93.9655
PWK/PhJ f 46.225 2.721 51.5928 40.8572
PWK/PhJ m 49.5182 2.842 55.1247 43.9117
SJL/J f 68.375 3.3326 74.9492 61.8008
SJL/J m 71.7636 2.842 77.3702 66.1571
SWR/J f 56.3889 3.142 62.5871 50.1906
SWR/J m 80.67 2.9807 86.5502 74.7898


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 68.5383 1.9241 72.334 64.7427
BALB/cJ both 75.875 2.1077 80.0329 71.7171
C3H/HeJ both 75.6928 2.1654 79.9646 71.4209
C57BL/6J both 78.8146 2.1512 83.0582 74.5709
C58/J both 65.59 2.1077 69.7479 61.4321
FVB/NJ both 79.1081 2.1183 83.2869 74.9292
NZB/BlNJ both 88.8067 2.018 92.7876 84.8258
PWK/PhJ both 47.8716 1.9673 51.7525 43.9907
SJL/J both 70.0693 2.1899 74.3894 65.7492
SWR/J both 68.5294 2.1654 72.8013 64.2576




  GWAS USING LINEAR MIXED MODELS