Project measure / variable:   Donahue2   femur_vBMD

ID, description, units MPD:17202   femur_vBMD   volumetric bone mineral density (vBMD), whole left femur   [g/cm3]  
Data set, strains Donahue2   inbred   10 strains     sex: both     age: 16wks
Procedure DXA
Ontology mappings

  STRAIN COMPARISON PLOT
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Donahue2 - volumetric bone mineral density (vBMD), whole left femur



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means0.684   g/cm3 0.659   g/cm3
Median of the strain means0.693   g/cm3 0.655   g/cm3
SD of the strain means± 0.0743 ± 0.0685
Coefficient of variation (CV)0.109 0.104
Min–max range of strain means0.566   –   0.832   g/cm3 0.570   –   0.803   g/cm3
Mean sample size per strain9.8   mice 10.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.0227 0.0227 20.4933 < 0.0001
strain 9 0.876 0.0973 88.0311 < 0.0001
sex:strain 9 0.0319 0.0035 3.2063 0.0012
Residuals 188 0.2079 0.0011


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 0.708 0.0348   10 0.011 0.0491 0.665, 0.779 0.32
129S1/SvImJ m 0.694 0.0472   14 0.0126 0.068 0.598, 0.762 0.51
BALB/cJ f 0.706 0.0237   10 0.00749 0.0335 0.665, 0.732 0.3
BALB/cJ m 0.688 0.0302   10 0.00955 0.0439 0.626, 0.732 0.42
C3H/HeJ f 0.832 0.00937   9 0.00312 0.0113 0.819, 0.85 1.99
C3H/HeJ m 0.803 0.025   11 0.00754 0.0312 0.749, 0.833 2.1
C57BL/6J f 0.566 0.0184   9 0.00614 0.0325 0.543, 0.6 -1.59
C57BL/6J m 0.606 0.0322   12 0.0093 0.0531 0.552, 0.656 -0.77
C58/J f 0.604 0.0534   9 0.0178 0.0885 0.516, 0.718 -1.08
C58/J m 0.57 0.0234   10 0.00739 0.041 0.536, 0.606 -1.3
FVB/NJ f 0.68 0.0289   11 0.00871 0.0425 0.622, 0.714 -0.05
FVB/NJ m 0.617 0.0244   9 0.00812 0.0395 0.571, 0.648 -0.61
NZB/BlNJ f 0.724 0.0308   11 0.0093 0.0426 0.673, 0.773 0.54
NZB/BlNJ m 0.695 0.0399   13 0.0111 0.0574 0.644, 0.787 0.53
PWK/PhJ f 0.641 0.0439   12 0.0127 0.0685 0.55, 0.708 -0.58
PWK/PhJ m 0.603 0.0371   10 0.0117 0.0615 0.541, 0.644 -0.82
SJL/J f 0.727 0.0327   8 0.0116 0.045 0.682, 0.773 0.58
SJL/J m 0.692 0.0323   11 0.00974 0.0466 0.628, 0.742 0.48
SWR/J f 0.651 0.0289   9 0.00965 0.0444 0.602, 0.689 -0.44
SWR/J m 0.622 0.0259   10 0.00818 0.0416 0.581, 0.662 -0.54


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 0.7077 0.0105 0.7284 0.687
129S1/SvImJ m 0.6944 0.0089 0.712 0.6769
BALB/cJ f 0.7059 0.0105 0.7266 0.6852
BALB/cJ m 0.6883 0.0105 0.709 0.6676
C3H/HeJ f 0.8316 0.0111 0.8534 0.8097
C3H/HeJ m 0.8025 0.01 0.8223 0.7828
C57BL/6J f 0.5661 0.0111 0.588 0.5442
C57BL/6J m 0.6062 0.0096 0.6251 0.5872
C58/J f 0.6039 0.0111 0.6258 0.582
C58/J m 0.5695 0.0105 0.5902 0.5488
FVB/NJ f 0.6799 0.01 0.6997 0.6601
FVB/NJ m 0.617 0.0111 0.6389 0.5951
NZB/BlNJ f 0.7239 0.01 0.7437 0.7041
NZB/BlNJ m 0.6948 0.0092 0.713 0.6767
PWK/PhJ f 0.6409 0.0096 0.6599 0.622
PWK/PhJ m 0.6031 0.0105 0.6238 0.5824
SJL/J f 0.7266 0.0118 0.7498 0.7034
SJL/J m 0.6924 0.01 0.7121 0.6726
SWR/J f 0.6514 0.0111 0.6733 0.6296
SWR/J m 0.6223 0.0105 0.643 0.6016


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 0.7011 0.0069 0.7146 0.6875
BALB/cJ both 0.6971 0.0074 0.7118 0.6824
C3H/HeJ both 0.8171 0.0075 0.8318 0.8023
C57BL/6J both 0.5861 0.0073 0.6006 0.5717
C58/J both 0.5867 0.0076 0.6018 0.5716
FVB/NJ both 0.6485 0.0075 0.6632 0.6337
NZB/BlNJ both 0.7094 0.0068 0.7228 0.6959
PWK/PhJ both 0.622 0.0071 0.6361 0.608
SJL/J both 0.7095 0.0077 0.7247 0.6943
SWR/J both 0.6369 0.0076 0.6519 0.6218




  GWAS USING LINEAR MIXED MODELS