Project measure / variable:   Donahue2   femur_stiffness

ID, description, units MPD:17212   femur_stiffness   slope of force-displacement curve in linear region   [N/mm]  
Data set, strains Donahue2   inbred   10 strains     sex: both     age: 16wks
Procedure biomechanical test
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  STRAIN COMPARISON PLOT
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Donahue2 - slope of force-displacement curve in linear region



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means170   N/mm 173   N/mm
Median of the strain means170   N/mm 165   N/mm
SD of the strain means± 29.5 ± 36.3
Coefficient of variation (CV)0.174 0.210
Min–max range of strain means127   –   223   N/mm 128   –   243   N/mm
Mean sample size per strain10.0   mice 11.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 1649.8662 1649.8662 3.6122 0.0589
strain 9 198725.5979 22080.622 48.3425 < 0.0001
sex:strain 9 10475.2259 1163.914 2.5482 0.0087
Residuals 191 87239.9356 456.7536


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 188.0 28.3   10 8.95 0.15 146.0, 240.0 0.61
129S1/SvImJ m 197.0 24.2   14 6.47 0.123 155.0, 241.0 0.67
BALB/cJ f 198.0 12.4   10 3.93 0.0629 176.0, 210.0 0.94
BALB/cJ m 185.0 21.6   10 6.82 0.116 144.0, 223.0 0.34
C3H/HeJ f 223.0 22.6   9 7.54 0.102 189.0, 253.0 1.79
C3H/HeJ m 243.0 27.9   11 8.4 0.115 179.0, 273.0 1.93
C57BL/6J f 148.0 15.6   10 4.93 0.105 120.0, 175.0 -0.75
C57BL/6J m 161.0 16.0   12 4.61 0.0995 136.0, 197.0 -0.33
C58/J f 160.0 19.1   10 6.03 0.119 129.0, 189.0 -0.34
C58/J m 151.0 17.3   10 5.47 0.115 117.0, 177.0 -0.6
FVB/NJ f 171.0 19.8   11 5.98 0.116 120.0, 193.0 0.03
FVB/NJ m 150.0 17.2   9 5.73 0.115 124.0, 185.0 -0.63
NZB/BlNJ f 184.0 22.0   11 6.62 0.119 136.0, 208.0 0.47
NZB/BlNJ m 211.0 16.2   13 4.5 0.077 181.0, 236.0 1.05
PWK/PhJ f 127.0 20.0   12 5.77 0.157 88.7, 157.0 -1.46
PWK/PhJ m 128.0 17.3   11 5.21 0.135 105.0, 163.0 -1.23
SJL/J f 168.0 21.6   8 7.62 0.128 126.0, 193.0 -0.07
SJL/J m 169.0 21.8   11 6.56 0.129 138.0, 195.0 -0.1
SWR/J f 134.0 21.4   9 7.12 0.16 87.0, 156.0 -1.22
SWR/J m 133.0 34.5   10 10.9 0.26 62.4, 179.0 -1.1


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 188.5 6.7584 201.8306 175.1694
129S1/SvImJ m 196.8571 5.7119 208.1236 185.5907
BALB/cJ f 197.7 6.7584 211.0306 184.3694
BALB/cJ m 185.3 6.7584 198.6306 171.9694
C3H/HeJ f 222.5556 7.1239 236.6072 208.5039
C3H/HeJ m 243.1818 6.4438 255.892 230.4716
C57BL/6J f 148.3 6.7584 161.6306 134.9694
C57BL/6J m 160.6667 6.1695 172.8358 148.4976
C58/J f 160.2 6.7584 173.5306 146.8694
C58/J m 150.9 6.7584 164.2306 137.5694
FVB/NJ f 170.8182 6.4438 183.5284 158.108
FVB/NJ m 150.0 7.1239 164.0517 135.9483
NZB/BlNJ f 184.0 6.4438 196.7102 171.2898
NZB/BlNJ m 211.0 5.9275 222.6917 199.3083
PWK/PhJ f 127.3083 6.1695 139.4774 115.1392
PWK/PhJ m 128.3636 6.4438 141.0739 115.6534
SJL/J f 168.375 7.5561 183.2791 153.4709
SJL/J m 169.0909 6.4438 181.8011 156.3807
SWR/J f 133.6667 7.1239 147.7184 119.615
SWR/J m 132.87 6.7584 146.2006 119.5394


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 192.6786 4.4244 201.4055 183.9516
BALB/cJ both 191.5 4.7789 200.9262 182.0738
C3H/HeJ both 232.8687 4.803 242.3423 223.395
C57BL/6J both 154.4833 4.5754 163.5082 145.4585
C58/J both 155.55 4.7789 164.9762 146.1238
FVB/NJ both 160.4091 4.803 169.8827 150.9354
NZB/BlNJ both 197.5 4.3777 206.1349 188.8651
PWK/PhJ both 127.836 4.4605 136.6342 119.0377
SJL/J both 168.733 4.9653 178.5268 158.9391
SWR/J both 133.2683 4.9098 142.9528 123.5839




  GWAS USING LINEAR MIXED MODELS