Phenotype measure:   Donahue2   femur_cortical_BMD

ID, description, units MPD:17203   femur_cortical_BMD   cortical shell volumetric bone mineral density (vBMD), whole left femur   [g/cm3]
Data set, strains Donahue2   inbred   10 strains     sex: both     age: 16wks
Procedure DXA
Ontology mappings

  STRAIN COMPARISON PLOT
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Donahue2 - cortical shell volumetric bone mineral density (vBMD), whole left femur



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means1.15   g/cm3 1.13   g/cm3
Median of the strain means1.15   g/cm3 1.12   g/cm3
SD of the strain means± 0.0522 ± 0.0531
Coefficient of variation (CV)0.0454 0.0469
Min–max range of strain means1.07   –   1.23   g/cm3 1.06   –   1.22   g/cm3
Mean sample size per strain9.8   mice 10.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 0.008 0.008 13.2029 0.0004
strain 9 0.5058 0.0562 92.8448 < 0.0001
sex:strain 9 0.0179 0.002 3.2921 0.001
Residuals 187 0.1132 0.0006


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 1.19 0.028   10 0.00884 0.0234 1.16, 1.25 0.79
129S1/SvImJ m 1.2 0.0307   13 0.0085 0.0256 1.16, 1.25 1.28
BALB/cJ f 1.19 0.0236   10 0.00746 0.0198 1.16, 1.23 0.79
BALB/cJ m 1.16 0.0125   10 0.00396 0.0108 1.15, 1.19 0.53
C3H/HeJ f 1.23 0.0259   9 0.00862 0.021 1.19, 1.26 1.55
C3H/HeJ m 1.22 0.0158   11 0.00476 0.0129 1.19, 1.24 1.66
C57BL/6J f 1.08 0.024   9 0.00799 0.0221 1.06, 1.12 -1.32
C57BL/6J m 1.08 0.0211   12 0.00609 0.0195 1.06, 1.13 -0.98
C58/J f 1.15 0.0501   9 0.0167 0.0435 1.1, 1.25 0.02
C58/J m 1.12 0.016   10 0.00504 0.0142 1.1, 1.14 -0.23
FVB/NJ f 1.14 0.0249   11 0.00752 0.0218 1.1, 1.18 -0.17
FVB/NJ m 1.09 0.0142   9 0.00475 0.013 1.07, 1.11 -0.79
NZB/BlNJ f 1.18 0.00934   11 0.00282 0.00795 1.16, 1.19 0.59
NZB/BlNJ m 1.17 0.021   13 0.00582 0.0179 1.15, 1.22 0.72
PWK/PhJ f 1.07 0.0296   12 0.00856 0.0278 1.02, 1.13 -1.51
PWK/PhJ m 1.06 0.017   10 0.00539 0.016 1.04, 1.09 -1.36
SJL/J f 1.16 0.037   8 0.0131 0.0319 1.12, 1.21 0.21
SJL/J m 1.11 0.0221   11 0.00666 0.0198 1.08, 1.16 -0.41
SWR/J f 1.1 0.0283   9 0.00943 0.0256 1.05, 1.14 -0.94
SWR/J m 1.11 0.0134   10 0.00423 0.0121 1.08, 1.13 -0.41


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 1.194 0.0078 1.2093 1.1787
129S1/SvImJ m 1.1969 0.0068 1.2104 1.1835
BALB/cJ f 1.193 0.0078 1.2083 1.1777
BALB/cJ m 1.163 0.0078 1.1783 1.1477
C3H/HeJ f 1.2322 0.0082 1.2484 1.216
C3H/HeJ m 1.2209 0.0074 1.2355 1.2063
C57BL/6J f 1.0833 0.0082 1.0995 1.0672
C57BL/6J m 1.0808 0.0071 1.0948 1.0668
C58/J f 1.1511 0.0082 1.1673 1.1349
C58/J m 1.121 0.0078 1.1363 1.1057
FVB/NJ f 1.1427 0.0074 1.1574 1.1281
FVB/NJ m 1.0944 0.0082 1.1106 1.0783
NZB/BlNJ f 1.1755 0.0074 1.1901 1.1608
NZB/BlNJ m 1.1731 0.0068 1.1865 1.1596
PWK/PhJ f 1.0667 0.0071 1.0807 1.0527
PWK/PhJ m 1.063 0.0078 1.0783 1.0477
SJL/J f 1.16 0.0087 1.1772 1.1428
SJL/J m 1.1145 0.0074 1.1292 1.0999
SWR/J f 1.1033 0.0082 1.1195 1.0872
SWR/J m 1.107 0.0078 1.1223 1.0917


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 1.1955 0.0052 1.2057 1.1853
BALB/cJ both 1.178 0.0055 1.1889 1.1671
C3H/HeJ both 1.2266 0.0055 1.2375 1.2157
C57BL/6J both 1.0821 0.0054 1.0928 1.0714
C58/J both 1.1361 0.0057 1.1472 1.1249
FVB/NJ both 1.1186 0.0055 1.1295 1.1077
NZB/BlNJ both 1.1743 0.005 1.1842 1.1643
PWK/PhJ both 1.0648 0.0053 1.0752 1.0544
SJL/J both 1.1373 0.0057 1.1485 1.126
SWR/J both 1.1052 0.0057 1.1163 1.094




  GWAS USING LINEAR MIXED MODELS