Project measure / variable:   Donahue2   femur_shaft_BMC

ID, description, units MPD:17205   femur_shaft_BMC   cross sectional bone mineral content (BMC), right femur mid-diaphysis   [g]  
Data set, strains Donahue2   inbred   10 strains     sex: both     age: 16wks
Procedure DXA
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  STRAIN COMPARISON PLOT
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Donahue2 - cross sectional bone mineral content (BMC), right femur mid-diaphysis



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means1.42   g 1.62   g
Median of the strain means1.44   g 1.59   g
SD of the strain means± 0.255 ± 0.338
Coefficient of variation (CV)0.179 0.208
Min–max range of strain means1.00   –   1.83   g 1.04   –   2.25   g
Mean sample size per strain10.0   mice 10.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2.2264 2.2264 104.8693 < 0.0001
strain 9 15.6437 1.7382 81.8747 < 0.0001
sex:strain 9 0.7906 0.0878 4.1377 0.0001
Residuals 191 4.0549 0.0212


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 1.44 0.133   10 0.0421 0.0924 1.21, 1.63 0.06
129S1/SvImJ m 1.64 0.237   15 0.0612 0.144 1.34, 2.2 0.06
BALB/cJ f 1.66 0.132   10 0.0417 0.0792 1.49, 1.81 0.93
BALB/cJ m 1.97 0.16   10 0.0504 0.0808 1.77, 2.31 1.04
C3H/HeJ f 1.83 0.127   9 0.0423 0.0694 1.66, 1.99 1.59
C3H/HeJ m 2.25 0.202   10 0.064 0.09 2.08, 2.72 1.87
C57BL/6J f 1.38 0.0884   10 0.0279 0.0641 1.27, 1.5 -0.17
C57BL/6J m 1.69 0.121   12 0.0349 0.0715 1.44, 1.86 0.21
C58/J f 1.4 0.088   10 0.0278 0.0631 1.29, 1.56 -0.09
C58/J m 1.51 0.122   10 0.0386 0.081 1.34, 1.75 -0.33
FVB/NJ f 1.43 0.065   11 0.0196 0.0454 1.34, 1.53 0.02
FVB/NJ m 1.53 0.108   9 0.036 0.0703 1.37, 1.67 -0.27
NZB/BlNJ f 1.52 0.111   11 0.0336 0.0735 1.35, 1.69 0.38
NZB/BlNJ m 1.75 0.211   13 0.0586 0.121 1.49, 2.13 0.39
PWK/PhJ f 1.0 0.0683   12 0.0197 0.068 0.91, 1.13 -1.67
PWK/PhJ m 1.04 0.202   11 0.0611 0.194 0.77, 1.35 -1.72
SJL/J f 1.55 0.233   8 0.0825 0.15 1.4, 2.11 0.49
SJL/J m 1.55 0.0976   11 0.0294 0.0631 1.41, 1.73 -0.21
SWR/J f 1.03 0.0475   9 0.0158 0.0459 0.95, 1.12 -1.55
SWR/J m 1.27 0.0657   10 0.0208 0.0519 1.18, 1.38 -1.04


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 1.44 0.0461 1.5309 1.3491
129S1/SvImJ m 1.6433 0.0376 1.7175 1.5691
BALB/cJ f 1.665 0.0461 1.7559 1.5741
BALB/cJ m 1.974 0.0461 2.0649 1.8831
C3H/HeJ f 1.8311 0.0486 1.9269 1.7353
C3H/HeJ m 2.247 0.0461 2.3379 2.1561
C57BL/6J f 1.379 0.0461 1.4699 1.2881
C57BL/6J m 1.6908 0.0421 1.7738 1.6079
C58/J f 1.395 0.0461 1.4859 1.3041
C58/J m 1.507 0.0461 1.5979 1.4161
FVB/NJ f 1.4309 0.0439 1.5176 1.3443
FVB/NJ m 1.5344 0.0486 1.6302 1.4386
NZB/BlNJ f 1.5173 0.0439 1.6039 1.4306
NZB/BlNJ m 1.7477 0.0404 1.8274 1.668
PWK/PhJ f 1.005 0.0421 1.088 0.922
PWK/PhJ m 1.0427 0.0439 1.1294 0.9561
SJL/J f 1.5538 0.0515 1.6554 1.4521
SJL/J m 1.5473 0.0439 1.6339 1.4606
SWR/J f 1.0344 0.0486 1.1302 0.9386
SWR/J m 1.266 0.0461 1.3569 1.1751


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 1.5417 0.0297 1.6003 1.483
BALB/cJ both 1.8195 0.0326 1.8838 1.7552
C3H/HeJ both 2.0391 0.0335 2.1051 1.973
C57BL/6J both 1.5349 0.0312 1.5964 1.4734
C58/J both 1.451 0.0326 1.5153 1.3867
FVB/NJ both 1.4827 0.0327 1.5473 1.4181
NZB/BlNJ both 1.6325 0.0298 1.6914 1.5736
PWK/PhJ both 1.0239 0.0304 1.0838 0.9639
SJL/J both 1.5505 0.0339 1.6173 1.4837
SWR/J both 1.1502 0.0335 1.2162 1.0842




  GWAS USING LINEAR MIXED MODELS