Project measure / variable:   Donahue2   femur_break_load

ID, description, units MPD:17208   femur_break_load   load at specimen failure (break point)   [N]  
Data set, strains Donahue2   inbred   10 strains     sex: both     age: 16wks
Procedure biomechanical test
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  STRAIN COMPARISON PLOT
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Donahue2 - load at specimen failure (break point)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means24.6   N 27.3   N
Median of the strain means23.1   N 24.4   N
SD of the strain means± 6.46 ± 7.94
Coefficient of variation (CV)0.262 0.291
Min–max range of strain means17.1   –   38.4   N 16.7   –   44.5   N
Mean sample size per strain10.0   mice 11.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 487.1348 487.1348 38.5532 < 0.0001
strain 9 9423.975 1047.1083 82.8711 < 0.0001
sex:strain 9 552.9512 61.439 4.8625 < 0.0001
Residuals 192 2425.9927 12.6354


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 23.0 3.25   10 1.03 0.141 18.1, 26.9 -0.25
129S1/SvImJ m 26.6 4.33   15 1.12 0.163 20.2, 36.1 -0.09
BALB/cJ f 29.1 2.73   10 0.864 0.0939 25.0, 32.3 0.69
BALB/cJ m 31.6 1.92   10 0.607 0.0607 28.9, 34.6 0.54
C3H/HeJ f 38.4 2.32   9 0.773 0.0604 34.8, 42.4 2.13
C3H/HeJ m 44.5 4.44   11 1.34 0.0997 36.9, 50.8 2.17
C57BL/6J f 17.1 4.34   10 1.37 0.254 12.3, 25.2 -1.16
C57BL/6J m 25.1 4.11   12 1.19 0.164 15.3, 29.9 -0.28
C58/J f 22.3 2.99   10 0.945 0.134 17.1, 26.5 -0.36
C58/J m 22.8 2.94   10 0.93 0.129 17.7, 26.8 -0.57
FVB/NJ f 26.0 2.65   11 0.8 0.102 21.0, 29.7 0.21
FVB/NJ m 23.3 2.54   9 0.846 0.109 17.7, 26.5 -0.5
NZB/BlNJ f 29.7 2.84   11 0.855 0.0954 25.4, 35.5 0.79
NZB/BlNJ m 35.6 4.09   13 1.13 0.115 28.4, 41.9 1.05
PWK/PhJ f 17.7 2.89   12 0.835 0.163 12.0, 21.4 -1.07
PWK/PhJ m 16.7 4.69   11 1.41 0.281 7.32, 21.6 -1.33
SJL/J f 23.1 3.85   8 1.36 0.167 18.0, 29.2 -0.24
SJL/J m 23.6 5.17   11 1.56 0.219 14.9, 30.5 -0.47
SWR/J f 19.8 1.62   9 0.539 0.0816 17.7, 22.9 -0.75
SWR/J m 23.2 3.45   10 1.09 0.149 19.3, 28.1 -0.52


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 23.0 1.1241 25.2171 20.7829
129S1/SvImJ m 26.5733 0.9178 28.3836 24.7631
BALB/cJ f 29.08 1.1241 31.2971 26.8629
BALB/cJ m 31.64 1.1241 33.8571 29.4229
C3H/HeJ f 38.3667 1.1849 40.7037 36.0296
C3H/HeJ m 44.5182 1.0718 46.6321 42.4042
C57BL/6J f 17.08 1.1241 19.2971 14.8629
C57BL/6J m 25.1417 1.0261 27.1656 23.1177
C58/J f 22.26 1.1241 24.4771 20.0429
C58/J m 22.8 1.1241 25.0171 20.5829
FVB/NJ f 25.9545 1.0718 28.0685 23.8406
FVB/NJ m 23.2556 1.1849 25.5926 20.9185
NZB/BlNJ f 29.7455 1.0718 31.8594 27.6315
NZB/BlNJ m 35.6154 0.9859 37.5599 33.6708
PWK/PhJ f 17.7083 1.0261 19.7323 15.6844
PWK/PhJ m 16.6564 1.0718 18.7703 14.5424
SJL/J f 23.0625 1.2568 25.5413 20.5837
SJL/J m 23.5727 1.0718 25.6867 21.4588
SWR/J f 19.8333 1.1849 22.1704 17.4963
SWR/J m 23.23 1.1241 25.4471 21.0129


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 24.7867 0.7256 26.2178 23.3555
BALB/cJ both 30.36 0.7948 31.9277 28.7923
C3H/HeJ both 41.4424 0.7988 43.0181 39.8668
C57BL/6J both 21.1108 0.761 22.6118 19.6098
C58/J both 22.53 0.7948 24.0977 20.9623
FVB/NJ both 24.6051 0.7988 26.1807 23.0294
NZB/BlNJ both 32.6804 0.7281 34.1166 31.2443
PWK/PhJ both 17.1823 0.7419 18.6457 15.719
SJL/J both 23.3176 0.8258 24.9465 21.6887
SWR/J both 21.5317 0.8166 23.1424 19.921




  GWAS USING LINEAR MIXED MODELS