Project measure / variable:   Donahue2   femur_break_energy

ID, description, units MPD:17210   femur_break_energy   area under load-displacement curve to break point   [N⋅mm]  
Data set, strains Donahue2   inbred   10 strains     sex: both     age: 16wks
Procedure biomechanical test
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  STRAIN COMPARISON PLOT
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Donahue2 - area under load-displacement curve to break point



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means5.75   N⋅mm 6.48   N⋅mm
Median of the strain means5.67   N⋅mm 6.02   N⋅mm
SD of the strain means± 1.71 ± 1.80
Coefficient of variation (CV)0.297 0.277
Min–max range of strain means3.36   –   8.48   N⋅mm 3.68   –   9.30   N⋅mm
Mean sample size per strain9.9   mice 11.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 34.3793 34.3793 9.4082 0.0025
strain 9 512.0899 56.8989 15.571 < 0.0001
sex:strain 9 95.2872 10.5875 2.8974 0.0031
Residuals 191 697.9459 3.6542


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 3.36 1.66   10 0.525 0.493 1.24, 6.42 -1.4
129S1/SvImJ m 5.18 2.03   15 0.524 0.392 2.32, 10.1 -0.72
BALB/cJ f 5.22 1.23   10 0.388 0.235 3.36, 7.2 -0.31
BALB/cJ m 5.59 0.855   10 0.27 0.153 3.96, 7.21 -0.5
C3H/HeJ f 6.97 1.54   9 0.514 0.221 5.12, 10.1 0.71
C3H/HeJ m 8.35 1.99   11 0.6 0.238 4.18, 11.7 1.04
C57BL/6J f 8.48 1.55   9 0.516 0.182 5.56, 11.3 1.6
C57BL/6J m 5.91 2.15   12 0.62 0.363 3.09, 9.53 -0.32
C58/J f 5.07 1.12   10 0.353 0.22 3.52, 6.85 -0.4
C58/J m 5.45 1.52   10 0.48 0.278 2.48, 7.57 -0.57
FVB/NJ f 6.12 0.988   11 0.298 0.161 4.55, 7.84 0.21
FVB/NJ m 6.12 2.62   9 0.872 0.428 2.93, 11.5 -0.2
NZB/BlNJ f 7.89 1.9   11 0.573 0.241 6.04, 11.8 1.25
NZB/BlNJ m 9.3 3.49   13 0.968 0.375 4.4, 16.2 1.57
PWK/PhJ f 3.51 1.16   12 0.336 0.332 1.68, 6.12 -1.32
PWK/PhJ m 3.68 1.14   11 0.344 0.31 2.09, 5.4 -1.56
SJL/J f 6.15 2.2   8 0.777 0.357 3.54, 9.0 0.23
SJL/J m 8.88 2.36   11 0.71 0.265 4.0, 12.7 1.33
SWR/J f 4.78 1.19   9 0.396 0.248 3.2, 6.96 -0.57
SWR/J m 6.36 2.57   10 0.813 0.404 2.63, 11.2 -0.07


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 3.362 0.6045 4.5543 2.1697
129S1/SvImJ m 5.1787 0.4936 6.1522 4.2051
BALB/cJ f 5.218 0.6045 6.4103 4.0257
BALB/cJ m 5.591 0.6045 6.7833 4.3987
C3H/HeJ f 6.9733 0.6372 8.2302 5.7165
C3H/HeJ m 8.3527 0.5764 9.4896 7.2159
C57BL/6J f 8.4811 0.6372 9.738 7.2243
C57BL/6J m 5.9133 0.5518 7.0018 4.8249
C58/J f 5.07 0.6045 6.2623 3.8777
C58/J m 5.453 0.6045 6.6453 4.2607
FVB/NJ f 6.1182 0.5764 7.255 4.9813
FVB/NJ m 6.1189 0.6372 7.3757 4.862
NZB/BlNJ f 7.8927 0.5764 9.0296 6.7559
NZB/BlNJ m 9.3023 0.5302 10.3481 8.2565
PWK/PhJ f 3.5058 0.5518 4.5943 2.4174
PWK/PhJ m 3.6809 0.5764 4.8178 2.5441
SJL/J f 6.155 0.6758 7.4881 4.8219
SJL/J m 8.8764 0.5764 10.0132 7.7395
SWR/J f 4.7833 0.6372 6.0402 3.5265
SWR/J m 6.364 0.6045 7.5563 5.1717


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 4.2703 0.3902 5.04 3.5007
BALB/cJ both 5.4045 0.4274 6.2476 4.5614
C3H/HeJ both 7.663 0.4296 8.5104 6.8157
C57BL/6J both 7.1972 0.4215 8.0285 6.3659
C58/J both 5.2615 0.4274 6.1046 4.4184
FVB/NJ both 6.1185 0.4296 6.9659 5.2712
NZB/BlNJ both 8.5975 0.3916 9.3699 7.8252
PWK/PhJ both 3.5934 0.399 4.3803 2.8064
SJL/J both 7.5157 0.4441 8.3917 6.6397
SWR/J both 5.5737 0.4392 6.4399 4.7074




  GWAS USING LINEAR MIXED MODELS