Project measure / variable:   Donahue2   femur_peak_energy

ID, description, units MPD:17211   femur_peak_energy   area under load-displacement curve to peak load   [N/mm2]  
Data set, strains Donahue2   inbred   10 strains     sex: both     age: 16wks
Procedure biomechanical test
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  STRAIN COMPARISON PLOT
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Donahue2 - area under load-displacement curve to peak load



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means4.34   N/mm2 5.27   N/mm2
Median of the strain means3.89   N/mm2 4.99   N/mm2
SD of the strain means± 1.31 ± 1.42
Coefficient of variation (CV)0.302 0.269
Min–max range of strain means2.72   –   6.67   N/mm2 3.10   –   7.81   N/mm2
Mean sample size per strain10.0   mice 11.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 49.2842 49.2842 31.2966 < 0.0001
strain 9 344.1737 38.2415 24.2843 < 0.0001
sex:strain 9 25.4524 2.828 1.7959 0.0712
Residuals 192 302.351 1.5747


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 2.93 1.13   10 0.358 0.386 1.25, 4.86 -1.08
129S1/SvImJ m 4.48 1.46   15 0.378 0.327 2.1, 6.92 -0.56
BALB/cJ f 4.78 1.03   10 0.327 0.217 3.36, 6.57 0.34
BALB/cJ m 5.23 0.683   10 0.216 0.131 3.96, 5.95 -0.03
C3H/HeJ f 6.1 1.27   9 0.423 0.208 4.71, 7.96 1.35
C3H/HeJ m 7.81 1.68   11 0.506 0.215 4.18, 10.3 1.8
C57BL/6J f 3.75 0.692   10 0.219 0.185 2.92, 4.88 -0.45
C57BL/6J m 5.57 1.94   12 0.559 0.348 2.96, 9.46 0.21
C58/J f 4.03 1.06   10 0.335 0.263 2.82, 5.63 -0.24
C58/J m 4.41 1.4   10 0.444 0.318 2.48, 6.17 -0.61
FVB/NJ f 5.13 1.18   11 0.357 0.231 3.23, 6.64 0.61
FVB/NJ m 4.65 1.32   9 0.439 0.283 2.93, 6.6 -0.44
NZB/BlNJ f 6.67 1.19   11 0.358 0.178 4.3, 8.23 1.78
NZB/BlNJ m 7.47 1.6   13 0.445 0.215 4.4, 10.8 1.55
PWK/PhJ f 2.72 0.618   12 0.178 0.228 1.62, 3.67 -1.24
PWK/PhJ m 3.1 0.966   11 0.291 0.311 2.02, 5.06 -1.53
SJL/J f 3.7 0.66   8 0.233 0.178 2.63, 4.74 -0.49
SJL/J m 5.11 1.1   11 0.331 0.215 3.8, 6.83 -0.11
SWR/J f 3.57 0.484   9 0.161 0.135 2.95, 4.32 -0.59
SWR/J m 4.86 1.81   10 0.571 0.372 2.63, 8.96 -0.29


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 2.929 0.3968 3.7117 2.1463
129S1/SvImJ m 4.4767 0.324 5.1157 3.8376
BALB/cJ f 4.778 0.3968 5.5607 3.9953
BALB/cJ m 5.227 0.3968 6.0097 4.4443
C3H/HeJ f 6.1033 0.4183 6.9284 5.2783
C3H/HeJ m 7.8064 0.3784 8.5526 7.0601
C57BL/6J f 3.748 0.3968 4.5307 2.9653
C57BL/6J m 5.57 0.3623 6.2845 4.8555
C58/J f 4.032 0.3968 4.8147 3.2493
C58/J m 4.413 0.3968 5.1957 3.6303
FVB/NJ f 5.1273 0.3784 5.8736 4.381
FVB/NJ m 4.6544 0.4183 5.4795 3.8294
NZB/BlNJ f 6.6727 0.3784 7.419 5.9264
NZB/BlNJ m 7.4708 0.348 8.1572 6.7843
PWK/PhJ f 2.7167 0.3623 3.4312 2.0022
PWK/PhJ m 3.1036 0.3784 3.8499 2.3574
SJL/J f 3.7 0.4437 4.5751 2.8249
SJL/J m 5.1091 0.3784 5.8554 4.3628
SWR/J f 3.5722 0.4183 4.3973 2.7472
SWR/J m 4.859 0.3968 5.6417 4.0763


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 3.7028 0.2562 4.2081 3.1976
BALB/cJ both 5.0025 0.2806 5.556 4.449
C3H/HeJ both 6.9548 0.282 7.5111 6.3986
C57BL/6J both 4.659 0.2687 5.1889 4.1291
C58/J both 4.2225 0.2806 4.776 3.669
FVB/NJ both 4.8909 0.282 5.4471 4.3346
NZB/BlNJ both 7.0717 0.257 7.5787 6.5647
PWK/PhJ both 2.9102 0.2619 3.4267 2.3936
SJL/J both 4.4045 0.2915 4.9796 3.8295
SWR/J both 4.2156 0.2883 4.7842 3.647




  GWAS USING LINEAR MIXED MODELS