Project measure / variable:   Donahue2   femur_area

ID, description, units MPD:17216   femur_area   cross sectional bone area, whole thigh area minus muscle area, femoral mid-diaphysis   [mm2]  
Data set, strains Donahue2   inbred   10 strains     sex: both     age: 16wks
Procedure computed tomography
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  STRAIN COMPARISON PLOT
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Donahue2 - cross sectional bone area, whole thigh area minus muscle area, femoral mid-diaphysis



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested10 strains10 strains
Mean of the strain means1.90   mm2 2.19   mm2
Median of the strain means1.98   mm2 2.25   mm2
SD of the strain means± 0.244 ± 0.352
Coefficient of variation (CV)0.128 0.161
Min–max range of strain means1.41   –   2.18   mm2 1.46   –   2.74   mm2
Mean sample size per strain10.0   mice 10.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4.2859 4.2859 143.1071 < 0.0001
strain 9 16.9714 1.8857 62.9647 < 0.0001
sex:strain 9 1.1077 0.1231 4.1098 0.0001
Residuals 191 5.7202 0.0299


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 1.88 0.133   10 0.0421 0.071 1.6, 2.03 -0.08
129S1/SvImJ m 2.05 0.18   15 0.0463 0.0877 1.77, 2.34 -0.38
BALB/cJ f 2.06 0.162   10 0.0514 0.0787 1.82, 2.26 0.66
BALB/cJ m 2.39 0.219   10 0.0692 0.0917 2.1, 2.86 0.58
C3H/HeJ f 1.82 0.145   9 0.0484 0.0796 1.62, 2.04 -0.33
C3H/HeJ m 2.33 0.247   10 0.0782 0.106 2.1, 2.94 0.41
C57BL/6J f 2.18 0.133   10 0.0422 0.0611 2.03, 2.39 1.15
C57BL/6J m 2.74 0.231   12 0.0665 0.0843 2.44, 3.19 1.58
C58/J f 2.03 0.136   10 0.0429 0.0669 1.84, 2.22 0.53
C58/J m 2.24 0.16   10 0.0506 0.0715 1.99, 2.51 0.16
FVB/NJ f 2.07 0.116   11 0.035 0.056 1.88, 2.29 0.7
FVB/NJ m 2.4 0.155   9 0.0518 0.0647 2.22, 2.6 0.61
NZB/BlNJ f 1.94 0.143   11 0.043 0.0735 1.74, 2.15 0.16
NZB/BlNJ m 2.19 0.301   13 0.0834 0.137 1.57, 2.63 0.01
PWK/PhJ f 1.41 0.0895   12 0.0258 0.0636 1.21, 1.57 -2.01
PWK/PhJ m 1.46 0.217   11 0.0655 0.149 1.14, 1.76 -2.06
SJL/J f 2.05 0.0965   8 0.0341 0.047 1.96, 2.21 0.61
SJL/J m 2.25 0.151   11 0.0454 0.0668 1.97, 2.42 0.18
SWR/J f 1.56 0.0732   9 0.0244 0.047 1.45, 1.68 -1.39
SWR/J m 1.8 0.0881   10 0.0279 0.049 1.64, 1.96 -1.09


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 1.877 0.0547 1.9849 1.7691
129S1/SvImJ m 2.0473 0.0447 2.1355 1.9592
BALB/cJ f 2.064 0.0547 2.1719 1.9561
BALB/cJ m 2.385 0.0547 2.4929 2.2771
C3H/HeJ f 1.8244 0.0577 1.9382 1.7107
C3H/HeJ m 2.328 0.0547 2.4359 2.2201
C57BL/6J f 2.183 0.0547 2.2909 2.0751
C57BL/6J m 2.7358 0.05 2.8344 2.6373
C58/J f 2.03 0.0547 2.1379 1.9221
C58/J m 2.237 0.0547 2.3449 2.1291
FVB/NJ f 2.07 0.0522 2.1729 1.9671
FVB/NJ m 2.3989 0.0577 2.5127 2.2851
NZB/BlNJ f 1.9409 0.0522 2.0438 1.838
NZB/BlNJ m 2.1938 0.048 2.2885 2.0992
PWK/PhJ f 1.4083 0.05 1.5069 1.3098
PWK/PhJ m 1.4582 0.0522 1.5611 1.3553
SJL/J f 2.0525 0.0612 2.1732 1.9318
SJL/J m 2.2518 0.0522 2.3547 2.1489
SWR/J f 1.5589 0.0577 1.6727 1.4451
SWR/J m 1.799 0.0547 1.9069 1.6911


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 1.9622 0.0353 2.0318 1.8925
BALB/cJ both 2.2245 0.0387 2.3008 2.1482
C3H/HeJ both 2.0762 0.0398 2.1546 1.9978
C57BL/6J both 2.4594 0.037 2.5325 2.3863
C58/J both 2.1335 0.0387 2.2098 2.0572
FVB/NJ both 2.2344 0.0389 2.3112 2.1577
NZB/BlNJ both 2.0674 0.0354 2.1373 1.9975
PWK/PhJ both 1.4333 0.0361 1.5045 1.362
SJL/J both 2.1522 0.0402 2.2315 2.0729
SWR/J both 1.6789 0.0398 1.7574 1.6005




  GWAS USING LINEAR MIXED MODELS