Studies from JAX Heart, Lung, and Blood Center (HLB)




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Data set Procedure What's in this data set Strains
Tested
Sex Age Year
Gavras1 tail cuff
with sodium chloride
Heart rate and blood pressure. Sodium chloride vs. control. None BP, HR, NaCl inbred  (11) both 9-12wks 2003
Naggert1 body weight
with high-fat diet
High-fat diet for 8wks. None BW inbred  (43) both 5, 21 wks 2003
Naggert1 DXA
with high-fat diet
Body mass, fat mass, lean mass, bone mineral density and content. High-fat diet. None BMD inbred  (43) both 5, 21 wks 2003
Naggert1 hormone quantification
with high-fat diet
Insulin and leptin, after 18wks on high-fat diet. Multiple readings per animal were averaged. None INS, LEP inbred  (43) both 5, 21 wks 2003
Naggert1 metabolic panel
with high-fat diet
Glucose (plasma). Baseline vs. high-fat diet (17wks). 4h fast. None GLU inbred  (43) both 5, 21 wks 2003
Paigen1 body weight
with high-fat diet
Baseline vs. high-fat diet for 8wks. None BW inbred  (44) both 15-19wks 2000
Paigen1 histopathology
with high-fat diet
Gallstone, gallbladder, and atherosclerosis lesion histopathology after 8wks on high-fat diet. gallstone, mucin, arc, filaments, crystals, cholesterol monohydrate CHOL inbred  (44) both 15-19wks 2000
Paigen1 lipid profile
with high-fat diet
Cholesterol, HDL, non-HDL. 4h fast, plasma. Hepatic lipids. 8wks on high-fat diet. HDL CHOL inbred  (44) both 15-19wks 2000
Paigen1 metabolic panel
with high-fat diet
Alanine transaminase, bile salts (plasma) after 8wks on high-fat diet. 4h fast. alanine transaminase ALT inbred  (44) both 15-19wks 2000
Paigen1 organ dimensions
with high-fat diet
Gallbladder volume after 8wks on high-fat diet. None None inbred  (44) both 15-19wks 2000
Paigen1 organ weights
with high-fat diet
Liver weight after 8wks on high-fat diet. None LW inbred  (44) both 15-19wks 2000
Paigen2 histopathology
with high-fat diet
Aortic lesion size histopathology. Baseline vs. high-fat diet (17wks). None None inbred  (43) both 7-9wks, 24-27wks 2002
Paigen2 lipid profile
with high-fat diet
Cholesterol, HDL, non-HDL, triglycerides. Baseline vs. high-fat diet (17wks). 4h fast, plasma. None CHOL, TG inbred  (43) both 7-9wks, 24-27wks 2002
Paigen3 body weight
with high-fat diet
Baseline vs. high-fat diet for 8wks. None BW obesity mutants  (8) both 15-19wks 2000
Paigen3 histopathology
with high-fat diet
Gallstone, gallbladder, and atherosclerosis lesion histopathology after 8wks on high-fat diet mucin, arc, filaments, crystals, cholesterol monohydrate CHOL obesity mutants  (8) both 15-19wks 2000
Paigen3 lipid profile
with high-fat diet
Cholesterol, HDL, non-HDL. 4h fast, plasma. Hepatic lipids. 8wks on high-fat diet. HDL CHOL obesity mutants  (8) both 15-19wks 2000
Paigen3 metabolic panel
with high-fat diet
Alanine transaminase, bile salts (plasma) after 8wks on high-fat diet. 4h fast. alanine transaminase ALT obesity mutants  (8) both 15-19wks 2000
Paigen3 organ dimensions
with high-fat diet
Gallbladder volume after 8wks on high-fat diet None None obesity mutants  (8) both 15-19wks 2000
Paigen3 organ weights
with high-fat diet
Liver weight after 8wks on high-fat diet. None LW obesity mutants  (8) both 15-19wks 2000
Paigen4 lipid profile Cholesterol, HDL, non-HDL, triglycerides. 4h fast, plasma. None CHOL, TG inbred  (43) both 10wks 2002
Peters1 coagulation test Fibrinogen. prothrombin time, thromboplastin time, fibrinogen. PT, PTT inbred  (43) both 10wks 2001
Peters1 complete blood count Hematology. cell counts, white cells, lymphocytes, neutrophils, monocytes, basophils, eosinophils, large unstained cells, red cell parameters, hemoglobin, hematocrit, reticulocytes, platelets, hematology BASO, CBC, RBC, WBC, CHCM, EOS, HCT, HGB, LUC, LYM, MCH, MCHC, MONO, MPV, NEUT, PLT, RET, RETIC inbred  (43) both 10wks 2001
Peters2 complete blood count Hematology. cell counts, white cells, lymphocytes, neutrophils, monocytes, basophils, eosinophils, large unstained cells, red cell parameters, hemoglobin, hematocrit, reticulocytes, platelets BASO, CBC, RBC, WBC, CHCM, EOS, HCT, HGB, LUC, LYM, MCH, MCHC, MONO, MPV, NEUT, PLT, RET, RETIC AXB BXA  (28) both 11wks 2004
Peters3 complete blood count Hematology. Variation over time of controls. cell counts, white cells, lymphocytes, neutrophils, monocytes, basophils, eosinophils, large unstained cells, red cell parameters, hemoglobin, hematocrit, reticulocytes, platelets BASO, CBC, RBC, WBC, CHCM, EOS, HCT, HGB, LUC, LYM, MCH, MCHC, MONO, MPV, NEUT, PLT, RET, RETIC one strain both 2005
Schwartz2 bronchoalveolar lavage assessment
with ovalbumin
Lung inflammatory changes. Ovalbumin vs. control. alveolar eosinophils, lymphocytes, neutrophils Alb, EOS, LYM, MCh, NEUT inbred  (8) m 6-8wks 2001
Schwartz3 study archive Lung, respiratory response to lipopolysaccharide endotoxin. None LPS inbred  (10) both 2003
Schwartz4 study archive Lung, respiratory response to ozone. Methacholine-sensitized. None MCh inbred  (8) both 2004
Schwartz5 study archive Lung, respiratory response to Streptococcus zooepidemicus. None None inbred  (8) both 2007
Seburn1 body weight Body weight None BW inbred  (16) both 7-9wks 2001
Seburn1 intake monitoring Food, caloric, and water intake. Daily. None None inbred  (16) both 7-9wks 2001
Seburn1 monitoring system Locomotor activity and energy metabolism. 24h test. body heat, oxygen volume, carbon dioxide volume, respiratory exchange ratio CO2, O2, RER inbred  (16) both 7-9wks 2001
Sugiyama1 tail cuff Heart rate and blood pressure. Conscious mice. None BP, HR inbred  (25) m 10wks 2007
Svenson1 tail cuff Heart rate and blood pressure. Conscious mice. None BP, HR inbred  (14) both 9wks 2004
Svenson3 coagulation test Fibrinogen, anti-thrombin III, factor VIII antithrombin III, AT3, clotting factor VIII, F8, fibrinogen PT, PTT B6.PWD consomic  (28) w/progenitors both 9wks 2006
Svenson3 complete blood count Hematology. cell counts, white cells, lymphocytes, neutrophils, monocytes, basophils, eosinophils, large unstained cells, red cell parameters, hemoglobin, hematocrit, reticulocytes, platelets BASO, CBC, RBC, WBC, CHCM, EOS, HCT, HGB, LUC, LYM, MCH, MCHC, MONO, MPV, NEUT, PLT, RET, RETIC B6.PWD consomic  (28) w/progenitors both 9wks 2006
Svenson3 lipid profile Cholesterol, HDL, triglycerides, free fatty acids. 4h fast, plasma. None CHOL, FFA, TG B6.PWD consomic  (28) w/progenitors both 9wks 2006
Svenson3 metabolic panel Glucose, bilirubin, blood urea nitrogen, aspartate transaminase (plasma). 4h fast. None AST, BIL, BUN, GLU, TBIL B6.PWD consomic  (28) w/progenitors both 9wks 2006
Svenson4 body size and weight Body weight, body length, body mass index. None BMI, BW B6.PWD consomic  (28) w/progenitors both 16wks 2006
Svenson4 DXA Body mass, fat mass, lean mass, bone mineral density and content. None BMD B6.PWD consomic  (28) w/progenitors both 16wks 2006