Project measure / variable:   Paigen3   st_pres

ID, description, units MPD:2819   st_pres   gallbladder, presence of stones (score: 1=present, 0=absent)   [score]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   8 strains     sex: both     age: 15-19wks
Procedure histopathology
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen3 - gallbladder, presence of stones (score: 1=present, 0=absent)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains8 strains
Mean of the strain means0.125   score 0.282   score
Median of the strain means0.100   score 0.195   score
SD of the strain means± 0.111 ± 0.299
Coefficient of variation (CV)0.887 1.06
Min–max range of strain means0   –   0.294   score 0   –   0.778   score
Mean sample size per strain18.9   mice 19.9   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 2.3721 2.3721 17.6181 < 0.0001
strain 6 7.4113 1.2352 9.1744 < 0.0001
sex:strain 6 3.0982 0.5164 3.8352 0.0011
Residuals 261 35.1403 0.1346


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 0.261 0.449   23 0.0936 1.72 1.23
B6(AU)-Tubtub/J m 0.308 0.471   26 0.0923 1.53 0.09
B6.BKS(D)-Leprdb/J m 0.0 0.0   16 0.0 0.0 -0.95
B6.Cg-Ay/J f 0.111 0.323   18 0.0762 2.91 -0.13
B6.Cg-Ay/J m 0.235 0.431   34 0.0738 1.83 -0.16
B6.Cg-Lepob/J f 0.0 0.0   17 0.0 0.0 -1.13
B6.Cg-Lepob/J m 0.0952 0.301   21 0.0656 3.16 -0.63
BKS.Cg-Dock7m +/+ Leprdb/J f 0.0556 0.236   18 0.0556 4.24 -0.63
BKS.Cg-Dock7m +/+ Leprdb/J m 0.0 0.0   15 0.0 0.0 -0.95
BKSChpLt.HRS-Cpefat/J f 0.294 0.47   17 0.114 1.6 1.53
BKSChpLt.HRS-Cpefat/J m 0.778 0.428   18 0.101 0.55 1.66
C57BL/6J f 0.1 0.308   20 0.0688 3.08 -0.22
C57BL/6J m 0.688 0.479   16 0.12 0.696 1.36
C57BLKS/J f 0.0526 0.229   19 0.0526 4.36 -0.65
C57BLKS/J m 0.154 0.376   13 0.104 2.44 -0.43


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 0.2609 0.0765 0.4115 0.1102
B6(AU)-Tubtub/J m 0.3077 0.072 0.4494 0.166
B6.Cg-Ay/J f 0.1111 0.0865 0.2814 -0.0592
B6.Cg-Ay/J m 0.2353 0.0629 0.3592 0.1114
B6.Cg-Lepob/J f 0.0 0.089 0.1752 -0.1752
B6.Cg-Lepob/J m 0.0952 0.0801 0.2529 -0.0624
BKS.Cg-Dock7m +/+ Leprdb/J f 0.0556 0.0865 0.2259 -0.1147
BKS.Cg-Dock7m +/+ Leprdb/J m 0.0 0.0947 0.1866 -0.1866
BKSChpLt.HRS-Cpefat/J f 0.2941 0.089 0.4694 0.1189
BKSChpLt.HRS-Cpefat/J m 0.7778 0.0865 0.9481 0.6075
C57BL/6J f 0.1 0.082 0.2616 -0.0616
C57BL/6J m 0.6875 0.0917 0.8681 0.5069
C57BLKS/J f 0.0526 0.0842 0.2184 -0.1131
C57BLKS/J m 0.1538 0.1018 0.3542 -0.0465


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 0.2843 0.0525 0.3877 0.1809
B6.Cg-Ay/J both 0.1732 0.0535 0.2785 0.0679
B6.Cg-Lepob/J both 0.0476 0.0599 0.1655 -0.0702
BKS.Cg-Dock7m +/+ Leprdb/J both 0.0278 0.0641 0.1541 -0.0985
BKSChpLt.HRS-Cpefat/J both 0.5359 0.062 0.6581 0.4138
C57BL/6J both 0.3938 0.0615 0.5149 0.2726
C57BLKS/J both 0.1032 0.066 0.2333 -0.0268




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA