Project measure / variable:   Paigen3   bilesalts

ID, description, units MPD:2825   bilesalts   bile salts (plasma)   [µmol/L]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   8 strains     sex: both     age: 15-19wks
Procedure metabolic panel
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  STRAIN COMPARISON PLOT
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Paigen3 - bile salts (plasma)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains8 strains
Mean of the strain means116   µmol/L 101   µmol/L
Median of the strain means104   µmol/L 95.2   µmol/L
SD of the strain means± 68.2 ± 50.3
Coefficient of variation (CV)0.586 0.499
Min–max range of strain means50.1   –   249   µmol/L 49.6   –   213   µmol/L
Mean sample size per strain18.4   mice 15.5   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 7910.7591 7910.7591 1.649 0.2004
strain 6 717795.4925 119632.5821 24.9377 < 0.0001
sex:strain 6 107786.4161 17964.4027 3.7447 0.0014
Residuals 235 1127355.9563 4797.2594


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 116.0 42.6   20 9.52 0.366 41.1, 159.0 -0.01
B6(AU)-Tubtub/J m 107.0 51.1   20 11.4 0.479 33.8, 161.0 0.13
B6.BKS(D)-Leprdb/J m 88.5 52.5   4 26.2 0.593 15.7, 141.0 -0.24
B6.Cg-Ay/J f 50.1 18.2   19 4.18 0.364 17.2, 74.0 -0.97
B6.Cg-Ay/J m 102.0 57.9   19 13.3 0.569 16.8, 171.0 0.03
B6.Cg-Lepob/J f 249.0 149.0   17 36.0 0.596 47.2, 543.0 1.94
B6.Cg-Lepob/J m 213.0 142.0   21 31.0 0.667 14.6, 436.0 2.23
BKS.Cg-Dock7m +/+ Leprdb/J f 104.0 53.1   17 12.9 0.508 27.3, 221.0 -0.18
BKS.Cg-Dock7m +/+ Leprdb/J m 110.0 54.4   14 14.5 0.496 31.2, 244.0 0.19
BKSChpLt.HRS-Cpefat/J f 93.9 80.4   14 21.5 0.856 25.9, 332.0 -0.33
BKSChpLt.HRS-Cpefat/J m 49.6 22.1   16 5.52 0.445 12.6, 105.0 -1.02
C57BL/6J f 51.9 17.7   16 4.43 0.342 20.8, 71.0 -0.95
C57BL/6J m 68.4 26.9   15 6.95 0.393 40.6, 130.0 -0.64
C57BLKS/J f 150.0 26.3   26 5.16 0.176 91.8, 189.0 0.49
C57BLKS/J m 66.8 29.6   15 7.65 0.444 23.0, 146.0 -0.67


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 116.155 15.4875 146.6671 85.6429
B6(AU)-Tubtub/J m 106.645 15.4875 137.1571 76.1329
B6.Cg-Ay/J f 50.0895 15.8899 81.3942 18.7847
B6.Cg-Ay/J m 101.6895 15.8899 132.9942 70.3847
B6.Cg-Lepob/J f 249.3059 16.7986 282.4009 216.2109
B6.Cg-Lepob/J m 213.3619 15.1143 243.1387 183.5851
BKS.Cg-Dock7m +/+ Leprdb/J f 104.4118 16.7986 137.5068 71.3167
BKS.Cg-Dock7m +/+ Leprdb/J m 109.7357 18.5111 146.2046 73.2668
BKSChpLt.HRS-Cpefat/J f 93.9214 18.5111 130.3904 57.4525
BKSChpLt.HRS-Cpefat/J m 49.5812 17.3156 83.6948 15.4677
C57BL/6J f 51.8937 17.3156 86.0073 17.7802
C57BL/6J m 68.4333 17.8834 103.6657 33.201
C57BLKS/J f 149.7231 13.5834 176.484 122.9622
C57BLKS/J m 66.76 17.8834 101.9923 31.5277


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 111.4 10.9513 132.9753 89.8247
B6.Cg-Ay/J both 75.8895 11.2358 98.0253 53.7537
B6.Cg-Lepob/J both 231.3339 11.2986 253.5934 209.0744
BKS.Cg-Dock7m +/+ Leprdb/J both 107.0737 12.4985 131.6972 82.4503
BKSChpLt.HRS-Cpefat/J both 71.7513 12.6737 96.7199 46.7828
C57BL/6J both 60.1635 12.4463 84.6842 35.6429
C57BLKS/J both 108.2415 11.2286 130.3631 86.1199




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA