Project measure / variable:   Paigen3   totalCh

ID, description, units MPD:2820   totalCh   total cholesterol (plasma)   [mg/dL]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   8 strains     sex: both     age: 15-19wks
Procedure lipid profile
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen3 - total cholesterol (plasma)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains8 strains
Mean of the strain means258   mg/dL 279   mg/dL
Median of the strain means193   mg/dL 269   mg/dL
SD of the strain means± 95.4 ± 82.4
Coefficient of variation (CV)0.370 0.295
Min–max range of strain means173   –   389   mg/dL 182   –   415   mg/dL
Mean sample size per strain18.4   mice 15.4   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 12272.3052 12272.3052 4.4745 0.0355
strain 6 1271442.7447 211907.1241 77.261 < 0.0001
sex:strain 6 209103.0951 34850.5159 12.7064 < 0.0001
Residuals 234 641802.0768 2742.7439


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 193.0 24.7   22 5.27 0.128 160.0, 238.0 -0.68
B6(AU)-Tubtub/J m 197.0 20.9   20 4.68 0.106 169.0, 243.0 -1.0
B6.BKS(D)-Leprdb/J m 415.0 57.7   4 28.9 0.139 377.0, 501.0 1.65
B6.Cg-Ay/J f 193.0 32.4   18 7.64 0.168 151.0, 297.0 -0.68
B6.Cg-Ay/J m 236.0 18.5   18 4.36 0.0786 198.0, 264.0 -0.52
B6.Cg-Lepob/J f 364.0 93.8   16 23.4 0.258 237.0, 543.0 1.12
B6.Cg-Lepob/J m 383.0 79.9   20 17.9 0.209 262.0, 589.0 1.26
BKS.Cg-Dock7m +/+ Leprdb/J f 389.0 91.3   18 21.5 0.235 240.0, 530.0 1.38
BKS.Cg-Dock7m +/+ Leprdb/J m 271.0 39.3   15 10.1 0.145 210.0, 338.0 -0.1
BKSChpLt.HRS-Cpefat/J f 317.0 65.2   13 18.1 0.206 261.0, 502.0 0.62
BKSChpLt.HRS-Cpefat/J m 282.0 51.2   16 12.8 0.182 214.0, 378.0 0.03
C57BL/6J f 173.0 12.7   15 3.29 0.0737 149.0, 191.0 -0.89
C57BL/6J m 267.0 39.5   15 10.2 0.148 197.0, 336.0 -0.15
C57BLKS/J f 174.0 41.0   27 7.89 0.235 116.0, 254.0 -0.88
C57BLKS/J m 182.0 39.8   15 10.3 0.219 140.0, 263.0 -1.18


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 193.2273 11.1656 215.2252 171.2294
B6(AU)-Tubtub/J m 196.75 11.7106 219.8216 173.6784
B6.Cg-Ay/J f 192.5556 12.344 216.8752 168.236
B6.Cg-Ay/J m 235.5556 12.344 259.8752 211.236
B6.Cg-Lepob/J f 363.5625 13.0928 389.3573 337.7677
B6.Cg-Lepob/J m 382.95 11.7106 406.0216 359.8784
BKS.Cg-Dock7m +/+ Leprdb/J f 389.1111 12.344 413.4307 364.7915
BKS.Cg-Dock7m +/+ Leprdb/J m 271.1333 13.5222 297.7741 244.4925
BKSChpLt.HRS-Cpefat/J f 316.5385 14.5252 345.1553 287.9217
BKSChpLt.HRS-Cpefat/J m 281.9375 13.0928 307.7323 256.1427
C57BL/6J f 172.8667 13.5222 199.5075 146.2259
C57BL/6J m 266.9333 13.5222 293.5741 240.2925
C57BLKS/J f 174.1481 10.0788 194.005 154.2913
C57BLKS/J m 182.0667 13.5222 208.7075 155.4259


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 194.9886 8.0902 210.9276 179.0496
B6.Cg-Ay/J both 214.0556 8.7285 231.2521 196.859
B6.Cg-Lepob/J both 373.2562 8.7829 390.56 355.9525
BKS.Cg-Dock7m +/+ Leprdb/J both 330.1222 9.1546 348.1581 312.0863
BKSChpLt.HRS-Cpefat/J both 299.238 9.7775 318.5013 279.9747
C57BL/6J both 219.9 9.5616 238.7379 201.0621
C57BLKS/J both 178.1074 8.4326 194.7209 161.494




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA