Project measure / variable:   Paigen3   ChMC

ID, description, units MPD:2815   ChMC   gallbladder, cholesterol monohydrate crystals (score: 0-4)   [score]  
high-fat diet study
Data set, strains Paigen3   obesity mutants   7 strains     sex: both     age: 15-19wks
Procedure histopathology
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen3 - gallbladder, cholesterol monohydrate crystals (score: 0-4)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested7 strains7 strains
Mean of the strain means0.179   score 0.767   score
Median of the strain means0.200   score 0.250   score
SD of the strain means± 0.111 ± 0.881
Coefficient of variation (CV)0.618 1.15
Min–max range of strain means0   –   0.312   score 0.0500   –   2.50   score
Mean sample size per strain7.7   mice 8.3   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 8.4043 8.4043 19.3375 < 0.0001
strain 6 15.2503 2.5417 5.8483 < 0.0001
sex:strain 6 17.3229 2.8871 6.6431 < 0.0001
Residuals 98 42.5918 0.4346


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
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Strain Sex Mean SD N mice SEM CV Min, Max Z score
B6(AU)-Tubtub/J f 0.222 0.441   9 0.147 1.98 0.39
B6(AU)-Tubtub/J m 0.222 0.667   9 0.222 3.0 -0.62
B6.Cg-Ay/J f 0.2 0.447   5 0.2 2.24 0.19
B6.Cg-Ay/J m 1.25 0.858   10 0.271 0.686 0.55
B6.Cg-Lepob/J f 0.286 0.393   7 0.149 1.38 0.97
B6.Cg-Lepob/J m 0.25 0.463   8 0.164 1.85 -0.59
BKS.Cg-Dock7m +/+ Leprdb/J f 0.0 0.0   9 0.0 0.0 -1.62
BKS.Cg-Dock7m +/+ Leprdb/J m 0.05 0.158   10 0.05 3.16 -0.81
BKSChpLt.HRS-Cpefat/J f 0.312 0.704   8 0.249 2.25 1.2
BKSChpLt.HRS-Cpefat/J m 0.9 0.907   10 0.287 1.01 0.15
C57BL/6J f 0.15 0.337   10 0.107 2.25 -0.26
C57BL/6J m 2.5 1.73   6 0.707 0.693 0.5, 4.0 1.97
C57BLKS/J f 0.0833 0.204   6 0.0833 2.45 -0.87
C57BLKS/J m 0.2 0.274   5 0.122 1.37 -0.64


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J f 0.2222 0.2197 0.6583 -0.2139
B6(AU)-Tubtub/J m 0.2222 0.2197 0.6583 -0.2139
B6.Cg-Ay/J f 0.2 0.2948 0.7851 -0.3851
B6.Cg-Ay/J m 1.25 0.2085 1.6637 0.8363
B6.Cg-Lepob/J f 0.2857 0.2492 0.7802 -0.2088
B6.Cg-Lepob/J m 0.25 0.2331 0.7125 -0.2125
BKS.Cg-Dock7m +/+ Leprdb/J f 0.0 0.2197 0.4361 -0.4361
BKS.Cg-Dock7m +/+ Leprdb/J m 0.05 0.2085 0.4637 -0.3637
BKSChpLt.HRS-Cpefat/J f 0.3125 0.2331 0.775 -0.15
BKSChpLt.HRS-Cpefat/J m 0.9 0.2085 1.3137 0.4863
C57BL/6J f 0.15 0.2085 0.5637 -0.2637
C57BL/6J m 2.5 0.2691 3.0341 1.9659
C57BLKS/J f 0.0833 0.2691 0.6174 -0.4508
C57BLKS/J m 0.2 0.2948 0.7851 -0.3851


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
B6(AU)-Tubtub/J both 0.2222 0.1554 0.5306 -0.0861
B6.Cg-Ay/J both 0.725 0.1805 1.0833 0.3667
B6.Cg-Lepob/J both 0.2679 0.1706 0.6064 -0.0707
BKS.Cg-Dock7m +/+ Leprdb/J both 0.025 0.1515 0.3256 -0.2756
BKSChpLt.HRS-Cpefat/J both 0.6062 0.1564 0.9165 0.296
C57BL/6J both 1.325 0.1702 1.6628 0.9872
C57BLKS/J both 0.1417 0.1996 0.5378 -0.2544




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CXB, or AXB/BXA