With: Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA

Supplementary Data (all Chesler4 data supplied in this file)

Submitted var_name | MPD var_name | MPD description | Units |
---|---|---|---|

Distance_(cm)_First _4min | OF_distance_first4 | distance traveled in first 4 min (response to novelty), 20 min test | cm |

Distance_(cm)_10min | OF_distance_first10 | distance traveled in first 10 min, 20 min test | cm |

Total_Distance_(cm) | OF_distance | total distance traveled, 20 min test | cm |

Distance_Traveled_Slope | OF_distance_slope | distance traveled (slope), 20 min test | slope |

Total_Time_Corner | OF_corner | total time in corners, 20 min test | s |

Percent_Time_in_Corner | OF_corner_pct | percent time in corners, 20 min test | % |

Pct_Time_Corner Slope | OF_corner_pct_slope | percent time in corners (slope), 20 min test | slope |

Total_Time_Periphery_(s) | OF_periphery | total time in periphery, 20 min test | s |

Percent_Time_Periphery | OF_periphery_pct | percent time in periphery, 20 min test | % |

Pct_Time_Periphery_Slope | OF_periphery_pct_slope | percent time in periphery (slope), 20 min test | slope |

Total_Time_Mobile | OF_mobile | total time mobile, 20 min test | s |

Total_Time_Immobile | OF_immobile | total time immobile, 20 min test | s |

PercentTime_Mobile | OF_mobile_pct | percent time mobile, 20 min test | % |

PercentTime_Immobile | OF_immobile_pct | percent time immobile, 20 min test | % |

LOG_Percent_Time_Mobile | OF_mobile_pct_log | percent time mobile (log), 20 min test | % |

Total_Time_Center_(s) | OF_center | total time in center, 20 min test | s |

log_Total_Time_Center | OF_center_log | total time in center (log), 20 min test | s |

Percent_Time_Center | OF_center_pct | percent time in center, 20 min test | % |

LOG_Percent_Time_Center | OF_center_pct_log | percent time in center (log), 20 min test | % |

Time_Center_Slope | OF_center_slope | total time in center (slope), 20 min test | slope |

OF_Fecal_Boli_Count | OF_fecal_boli | number of fecal boli, 20 min test | n |

Arena_Assignment | OF_arena | arena assignment, 20 min test | - |

Distance_Traveled_cm_Light | LD_distance_light | distance traveled in light compartment, 20 min test | cm |

Light_Dark_Transitions | LD_transitions | number of light-dark transitions, 20 min test | n |

Duration_Light_4mins | LD_light_first4 | time in light compartment first 4 min (response to novelty), 20 min test | s |

Total_Duration_Light | LD_light | time in light compartment, 20 min test | s |

Pct_Time_Light_4mins | LD_light_first4_pct | percent time in light compartment first 4 min (response to novelty), 20 min test | % |

Pct_Time_Light | LD_light_pct | percent time in light compartment, 20 min test | % |

LDBOX_Pct_Time_Light_Slope | LD_light_pct_slope | percent time in light compartment (slope), 20 min test | slope |

SLOPE_Duration | LD_duration_slope | time in light compartment (slope), 20 min test | slope |

SLOPE_Distance | LD_distance_slope | distance traveled in light compartment (slope), 20 min test | slope |

Arena | LD_arena | arena, 20 min test | - |

VC_TOP_Distance_4mins | VC_top_distance_first4 | distance traveled in top during first 4 min (response to novelty), 20 min test | cm |

VC_TOP_Duration_4mins | VC_top_time_first4 | time in top during first 4 min (response to novelty), 20 min test | s |

TOP_Total_Distance | VC_top_distance | total distance traveled in top, 20 min test | cm |

TOP_Total_Duration | VC_top_time | total time in top, 20 min test | s |

PCT_Duration_Top | VC_top_time_pct | percent time in top, 20 min test | % |

TOP_Frequency | VC_top_frequency | number of top entries, 20 min test | n |

TOP_Duration_Immobile | VC_top_time_immobile | time immobile in top, 20 min test | s |

TOP_Mean_Velocity | VC_top_velocity | mean velocity in top, 20 min test | cm/s |

VC_BOTTOM_Distance_4mins | VC_bottom_distance_first4 | distance traveled in bottom during first 4 min (response to novelty), 20 min test | cm |

VC_BOTTOM_Duration_4mins | VC_bottom_time_first4 | time in bottom during first 4 min (response to novelty), 20 min test | s |

BOTTOM_Total_Distance | VC_bottom_distance | total distance traveled in bottom, 20 min test | cm |

BOTTOM_Total_Duration | VC_bottom_time | total time in bottom, 20 min test | s |

PCT_Duration_Bottom | VC_bottom_time_pct | percent time in bottom, 20 min test | % |

BOTTOM_Total_Frequency | VC_bottom_frequency | number of bottom entries, 20 min test | n |

BOTTOM_Duration_Immobile | VC_bottom_time_immobile | time immobile in bottom, 20 min test | s |

BOTTOM_Mean_Velocity | VC_bottom_velocity | mean velocity in bottom, 20 min test | cm/s |

BOTTOM_Total_Transitions | VC_bottom_transitions | number of top to bottom transitions, 20 min test | n |

TOTAL_Distance_Traveled | VC_total_distance | total distance traveled, 20 min test | cm |

TOTAL_Duration_Immobile | VC_total_time_immobile | total time immobile, 20 min test | s |

TOTAL_Mean_Velocity | VC_total_velocity | total mean velocity, 20 min test | cm/s |

RATIO_Top_Bottom_Duration_First_4mins | VC_top_bottom_ratio_time_first4 | top to bottom ratio for time spent during first 4 min (response to novelty), 20 min test | ratio |

RATIO_Duration_Bottom_Top | VC_bottom_top_ratio_time | bottom to top ratio for time, 20 min test | ratio |

LOG_RATIO_Duration_Bottom_Top | VC_top_bottom_ratio_time_log | bottom to top ratio for time, 20 min test (log) | ratio |

RATIO_Duration_Top_Bottom | VC_top_bottom_ratio_time | top to bottom ratio for time, 20 min test | ratio |

RATIO_Distance_Bottom_Top | VC_bottom_top_ratio_distance | bottom to top ratio for distance, 20 min test | ratio |

RATIO_Distance_Top_Bottom | VC_top_bottom_ratio_distance | top to bottom ratio for distance, 20 min test | ratio |

SLOPE_Bottom_Distance | VC_bottom_distance_slope | total distance traveled, 20 min test (slope) | slope |

SLOPE_Bottom_Duration | VC_bottom_time_slope | total time in bottom, 20 min test (slope) | slope |

PCT_Duration_Neutral | VC_neutral_time | percent time in neutral, 20 min test | % |

RATIO_Duration_Immobile_Total_Bottom | VC_total_bottom_ratio_time_immobile | total to bottom ratio for time immobile | ratio |

RATIO_Distance_Bottom_Total | VC_bottom_total_ratio_distance | bottom to total ratio for distance | ratio |

Latency to respond (s) - trial 1 | HP_latency | latency of hindpaw withdrawal, 55°C heat stimulation | s |

ln(trial_1) | HP_latency_log | latency of hindpaw withdrawal, 55°C heat stimulation (log) | s |

Climbing | TS_climbing | climbing (0=no; 1=yes) | designation |

Duration_climbing | TS_time_climbing | time spent climbing (2 trials, 5-min) | s |

Frequency_climbing | TS_frequency_climbing | average frequency climbing (2 trials, 5-min) | n |

Latency_climbing | TS_latency_climbing | latency to first climb (2 trials, 5-min) | s |

Duration_nonclimbing | TS_time_nonclimbing | time spent not climbing (2 trials, 5-min) | s |

Frequency_nonclimbing | TS_frequency_nonclimbing | frequency not climbing (2 trials, 5-min) | n |

Duration_immobile_2 | TS_time_immobile | average time immobile (2 trials, 5-min) | s |

Frequency_immobile_2 | TS_frequency_immobile | frequency immobile (2 trials, 5-min) | n |

Latency_immobile | TS_latency_immobile | average latency to first immobility episode (2 trials, 5-min) | s |

Duration_mobile_2 | TS_time_mobile | time mobile (2 trials, 5-min) | s |

Frequency_mobile_2 | TS_frequency_mobile | frequency mobile (2 trials, 5-min) | n |

Centerpoint_Moving_Duration | TS_time_center_moving | time moving at centerpoint (2 trials, 5-min) | s |

Centerpoint_NotMoving_Duration | TS_time_center_notmoving | time not moving at centerpoint (2 trials, 5-min) | s |

Mean_velocity | TS_velocity | mean velocity (2 trials, 5-min) | cm/s |

log_latclimb | TS_latency_climbing_log | latency to first climb (log) (2 trials, 5-min) | s |

sqrtfreqimmobile | TS_frequency_immobile_sqrt | frequency immobile (square root) (2 trials, 5-min) | n |

loglatimmobile | TS_latency_immobile_log | latency to first immobile (log) (2 trials, 5-min) | s |

Trial_ID | TS_trial | trial ID | - |

Dissection_WT(g) | bw | body weight at time of dissection, 20 min test | g |

Download supplementary data: Chesler4_suppdata.xlxs