Phenotype measure:   Chesler4   HP_latency

ID, description, units MPD:47024   HP_latency   latency of hindpaw withdrawal, 55°C heat stimulation   [s]
Data set, strains Chesler4   DO population w/par   9 strains     sex: both     age: 12-16wks
Procedure nociception assay
Ontology mappings

Plot Options Bins number: (min: 10, max: 40)


Distribution of Individual Animals with Boxplots.





  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested9 strains9 strains
Mean of the strain means12.6   s 10.7   s
Median of the strain means12.0   s 9.44   s
SD of the strain means± 5.61 ± 4.71
Coefficient of variation (CV)0.447 0.442
Min–max range of strain means6.39   –   26.0   s 6.01   –   22.3   s
Mean sample size per strain8.0   mice 8.0   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 207.4199 207.4199 9.7281 0.002
strain 8 3959.6946 494.9618 23.214 < 0.0001
sex:strain 8 129.0071 16.1259 0.7563 0.6416
Residuals 379 8080.9102 21.3217


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 12.0 2.42   8 0.855 0.201 8.93, 15.5 -0.1
129S1/SvImJ m 9.44 3.09   8 1.09 0.327 5.77, 13.6 -0.26
A/J f 13.7 7.4   8 2.62 0.541 4.8, 30.0 0.2
A/J m 8.18 3.36   8 1.19 0.411 3.07, 11.6 -0.53
C57BL/6J f 11.0 1.89   8 0.668 0.171 8.77, 13.9 -0.28
C57BL/6J m 9.98 1.68   8 0.595 0.169 7.78, 12.7 -0.15
CAST/EiJ f 13.8 4.86   8 1.72 0.351 7.37, 21.1 0.22
CAST/EiJ m 10.9 7.75   8 2.74 0.708 6.56, 30.0 0.05
J:DO f 9.6 4.96   137 0.424 0.517 2.32, 28.1 -0.53
J:DO m 8.37 4.47   132 0.389 0.534 2.41, 30.0 -0.49
NOD/ShiLtJ f 8.22 3.2   8 1.13 0.39 2.3, 12.5 -0.77
NOD/ShiLtJ m 8.51 2.74   8 0.967 0.322 6.11, 14.4 -0.46
NZO/HlLtJ f 6.39 2.03   8 0.716 0.317 3.74, 10.7 -1.1
NZO/HlLtJ m 6.01 1.5   8 0.531 0.25 4.36, 8.19 -0.99
PWK/PhJ f 26.0 4.44   8 1.57 0.171 19.1, 30.0 2.4
PWK/PhJ m 22.3 8.16   8 2.89 0.366 4.85, 30.0 2.47
WSB/EiJ f 12.3 1.99   8 0.704 0.162 10.1, 15.9 -0.05
WSB/EiJ m 12.3 4.0   8 1.41 0.326 5.35, 17.0 0.35


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 12.0487 1.6325 15.2587 8.8388
129S1/SvImJ m 9.4387 1.6325 12.6487 6.2288
A/J f 13.6787 1.6325 16.8887 10.4688
A/J m 8.1762 1.6325 11.3862 4.9663
C57BL/6J f 11.025 1.6325 14.235 7.815
C57BL/6J m 9.98 1.6325 13.19 6.77
CAST/EiJ f 13.8413 1.6325 17.0512 10.6313
CAST/EiJ m 10.9438 1.6325 14.1537 7.7338
J:DO f 9.5976 0.3945 10.3733 8.8219
J:DO m 8.3723 0.4019 9.1625 7.582
NOD/ShiLtJ f 8.2225 1.6325 11.4325 5.0125
NOD/ShiLtJ m 8.5062 1.6325 11.7162 5.2963
NZO/HlLtJ f 6.3863 1.6325 9.5962 3.1763
NZO/HlLtJ m 6.0112 1.6325 9.2212 2.8013
PWK/PhJ f 26.02 1.6325 29.23 22.81
PWK/PhJ m 22.3037 1.6325 25.5137 19.0938
WSB/EiJ f 12.2625 1.6325 15.4725 9.0525
WSB/EiJ m 12.2575 1.6325 15.4675 9.0475


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 10.7437 1.1544 13.0136 8.4739
A/J both 10.9275 1.1544 13.1973 8.6577
C57BL/6J both 10.5025 1.1544 12.7723 8.2327
CAST/EiJ both 12.3925 1.1544 14.6623 10.1227
J:DO both 8.9849 0.2816 9.5386 8.4313
NOD/ShiLtJ both 8.3644 1.1544 10.6342 6.0946
NZO/HlLtJ both 6.1988 1.1544 8.4686 3.9289
PWK/PhJ both 24.1619 1.1544 26.4317 21.8921
WSB/EiJ both 12.26 1.1544 14.5298 9.9902




GWAS analysis not available: Strain panel must be either Inbred, HMDP, BXD, BXH, CKB, or AXBBXA