Project measure / variable:   Paigen1   totalCh

ID, description, units MPD:2920   totalCh   total cholesterol (plasma)   [mg/dL]  
high-fat diet study
Data set, strains Paigen1   inbred   43 strains     sex: both     age: 15-19wks
Procedure lipid profile
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen1 - total cholesterol (plasma)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested43 strains42 strains
Mean of the strain means227   mg/dL 235   mg/dL
Median of the strain means201   mg/dL 210   mg/dL
SD of the strain means± 93.6 ± 105
Coefficient of variation (CV)0.412 0.447
Min–max range of strain means101   –   520   mg/dL 121   –   686   mg/dL
Mean sample size per strain9.1   mice 8.7   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 31499.6386 31499.6386 10.0844 0.0016
strain 41 6647871.6992 162143.2122 51.9093 < 0.0001
sex:strain 41 626455.5268 15279.4031 4.8916 < 0.0001
Residuals 682 2130286.6811 3123.5875


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 218.0 14.2   10 4.48 0.065 195.0, 241.0 -0.1
129S1/SvImJ m 233.0 27.6   10 8.74 0.119 192.0, 270.0 -0.02
A/J f 331.0 107.0   9 35.6 0.322 219.0, 594.0 1.11
A/J m 275.0 32.5   10 10.3 0.118 228.0, 320.0 0.38
AKR/J f 152.0 24.9   10 7.86 0.164 122.0, 201.0 -0.8
AKR/J m 135.0 3.81   9 1.27 0.0283 128.0, 139.0 -0.95
BALB/cJ f 182.0 15.4   10 4.87 0.0845 160.0, 205.0 -0.48
BALB/cJ m 124.0 13.6   10 4.31 0.11 99.0, 141.0 -1.06
BPH/2J f 163.0 26.4   9 8.78 0.161 131.0, 222.0 -0.69
BPH/2J m 155.0 12.7   8 4.5 0.0822 138.0, 171.0 -0.76
BPL/1J f 202.0 16.8   10 5.3 0.0829 185.0, 227.0 -0.27
BPL/1J m 205.0 11.2   10 3.55 0.0549 185.0, 217.0 -0.29
BPN/3J f 185.0 24.7   10 7.82 0.134 146.0, 224.0 -0.45
BPN/3J m 194.0 14.1   9 4.7 0.0727 172.0, 212.0 -0.39
BTBR T+ Itpr3tf/J f 184.0 12.6   9 4.19 0.0683 166.0, 202.0 -0.46
BTBR T+ Itpr3tf/J m 194.0 17.2   15 4.44 0.0887 166.0, 226.0 -0.39
C3H/HeJ f 301.0 18.9   8 6.68 0.0627 281.0, 328.0 0.79
C3H/HeJ m 251.0 32.3   10 10.2 0.129 189.0, 282.0 0.15
C57BL/10J f 128.0 14.7   10 4.66 0.115 112.0, 150.0 -1.06
C57BL/10J m 196.0 18.0   9 5.99 0.0919 180.0, 234.0 -0.38
C57BL/6J f 173.0 12.7   15 3.29 0.0737 149.0, 191.0 -0.58
C57BL/6J m 267.0 39.5   15 10.2 0.148 197.0, 336.0 0.3
C57BLKS/J f 174.0 41.0   27 7.89 0.235 116.0, 254.0 -0.57
C57BLKS/J m 182.0 39.8   15 10.3 0.219 140.0, 263.0 -0.51
C57BR/cdJ f 265.0 43.1   10 13.6 0.163 211.0, 344.0 0.4
C57BR/cdJ m 226.0 22.6   10 7.14 0.0999 187.0, 256.0 -0.09
C57L/J f 129.0 7.98   8 2.82 0.0617 117.0, 143.0 -1.05
C57L/J m 158.0 14.5   9 4.83 0.0915 125.0, 175.0 -0.74
C58/J f 331.0 49.1   9 16.4 0.148 243.0, 397.0 1.11
C58/J m 498.0 152.0   10 48.1 0.306 179.0, 683.0 2.5
CAST/EiJ f 429.0 62.4   8 22.1 0.145 323.0, 493.0 2.16
CAST/EiJ m 295.0 38.3   9 12.8 0.13 268.0, 364.0 0.57
CBA/J f 101.0 9.14   10 2.89 0.0908 86.0, 113.0 -1.35
CBA/J m 176.0 18.1   10 5.74 0.103 141.0, 199.0 -0.57
CE/J f 178.0 16.2   9 5.39 0.0908 152.0, 200.0 -0.53
CE/J m 255.0 50.8   6 20.8 0.199 203.0, 327.0 0.19
CZECHII/EiJ f 207.0 35.4   7 13.4 0.171 167.0, 252.0 -0.22
CZECHII/EiJ m 229.0 109.0   7 41.4 0.478 123.0, 410.0 -0.06
DBA/1J f 130.0 13.4   7 5.05 0.103 110.0, 143.0 -1.04
DBA/1J m 148.0 29.7   9 9.9 0.201 112.0, 198.0 -0.83
DBA/2J f 119.0 12.7   9 4.23 0.107 102.0, 140.0 -1.16
DBA/2J m 202.0 12.9   6 5.26 0.0638 184.0, 215.0 -0.32
FVB/NJ f 177.0 18.2   10 5.76 0.103 150.0, 202.0 -0.54
FVB/NJ m 239.0 43.8   3 25.3 0.184 189.0, 272.0 0.03
I/LnJ f 164.0 21.2   10 6.71 0.129 123.0, 199.0 -0.68
I/LnJ m 165.0 15.1   10 4.77 0.0913 143.0, 191.0 -0.67
KK/HlJ f 296.0 35.3   8 12.5 0.12 249.0, 358.0 0.73
KK/HlJ m 188.0 27.1   8 9.57 0.144 152.0, 228.0 -0.45
LP/J f 167.0 12.0   9 3.99 0.0716 153.0, 186.0 -0.64
LP/J m 167.0 17.5   10 5.54 0.105 144.0, 196.0 -0.65
MOLF/EiJ f 520.0 41.4   7 15.6 0.0796 453.0, 564.0 3.13
MOLF/EiJ m 686.0 371.0   9 124.0 0.541 132.0, 1158.0 4.28
NOD/ShiLtJ f 311.0 82.7   9 27.6 0.266 237.0, 507.0 0.89
NOD/ShiLtJ m 303.0 24.0   7 9.06 0.0791 275.0, 342.0 0.64
NON/ShiLtJ f 201.0 11.0   9 3.66 0.0547 180.0, 219.0 -0.28
NON/ShiLtJ m 261.0 26.6   9 8.85 0.102 239.0, 322.0 0.24
NZB/BlNJ f 358.0 61.0   11 18.4 0.17 249.0, 478.0 1.4
NZB/BlNJ m 333.0 20.8   9 6.93 0.0625 299.0, 361.0 0.93
NZW/LacJ f 224.0 29.1   8 10.3 0.13 179.0, 272.0 -0.03
NZW/LacJ m 216.0 12.2   9 4.06 0.0565 199.0, 231.0 -0.18
PERA/EiJ f 268.0 25.7   8 9.09 0.0958 244.0, 308.0 0.44
PERA/EiJ m 294.0 150.0   4 75.2 0.511 186.0, 517.0 0.56
P/J f 272.0 21.7   10 6.87 0.0798 246.0, 312.0 0.48
P/J m 240.0 28.8   10 9.09 0.12 204.0, 282.0 0.04
PL/J f 202.0 43.7   9 14.6 0.217 149.0, 277.0 -0.27
PL/J m 237.0 33.5   3 19.3 0.141 199.0, 263.0 0.01
RBF/DnJ f 489.0 32.9   10 10.4 0.0672 431.0, 543.0 2.8
RBF/DnJ m 472.0 45.1   8 15.9 0.0955 425.0, 560.0 2.25
RF/J f 156.0 6.42   9 2.14 0.0413 147.0, 166.0 -0.76
RF/J m 174.0 28.4   6 11.6 0.164 119.0, 196.0 -0.58
RIIIS/J f 170.0 29.9   9 9.97 0.176 139.0, 221.0 -0.61
RIIIS/J m 160.0 18.0   9 6.01 0.112 134.0, 192.0 -0.72
SEA/GnJ f 194.0 15.2   9 5.05 0.0783 173.0, 209.0 -0.36
SEA/GnJ m 161.0 11.7   10 3.7 0.0724 139.0, 175.0 -0.71
SJL/J f 182.0 29.1   10 9.21 0.16 136.0, 231.0 -0.48
SJL/J m 186.0 18.8   9 6.27 0.101 154.0, 218.0 -0.47
SM/J f 228.0 44.2   8 15.6 0.194 147.0, 292.0 0.01
SM/J m 255.0 66.9   6 27.3 0.262 146.0, 318.0 0.19
SPRET/EiJ f 166.0 11.8   6 4.82 0.0714 152.0, 180.0 -0.65
SPRET/EiJ m 121.0 66.7   5 29.8 0.552 53.0, 197.0 -1.09
SWR/J f 220.0 14.4   9 4.79 0.0653 200.0, 242.0 -0.08
SWR/J m 196.0 34.8   8 12.3 0.177 149.0, 263.0 -0.38
WSB/EiJ f 235.0 37.3   8 13.2 0.159 201.0, 320.0 0.08
WSB/EiJ m 237.0 15.5   8 5.47 0.0653 215.0, 265.0 0.01
YBR/EiJ f 289.0 82.6   5 36.9 0.285 212.0, 423.0 0.66


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 217.9 17.6737 252.6013 183.1987
129S1/SvImJ m 232.8 17.6737 267.5013 198.0987
A/J f 330.8889 18.6297 367.4673 294.3105
A/J m 275.0 17.6737 309.7013 240.2987
AKR/J f 151.9 17.6737 186.6013 117.1987
AKR/J m 134.5556 18.6297 171.134 97.9771
BALB/cJ f 182.1 17.6737 216.8013 147.3987
BALB/cJ m 123.9 17.6737 158.6013 89.1987
BPH/2J f 163.2222 18.6297 199.8007 126.6438
BPH/2J m 154.875 19.7598 193.6723 116.0777
BPL/1J f 202.1 17.6737 236.8013 167.3987
BPL/1J m 204.6 17.6737 239.3013 169.8987
BPN/3J f 185.2 17.6737 219.9013 150.4987
BPN/3J m 193.7778 18.6297 230.3562 157.1993
BTBR T+ Itpr3tf/J f 183.8889 18.6297 220.4673 147.3105
BTBR T+ Itpr3tf/J m 194.0667 14.4305 222.4002 165.7331
C3H/HeJ f 301.375 19.7598 340.1723 262.5777
C3H/HeJ m 250.9 17.6737 285.6013 216.1987
C57BL/10J f 128.1 17.6737 162.8013 93.3987
C57BL/10J m 195.7778 18.6297 232.3562 159.1993
C57BL/6J f 172.8667 14.4305 201.2002 144.5331
C57BL/6J m 266.9333 14.4305 295.2669 238.5998
C57BLKS/J f 174.1481 10.7559 195.2667 153.0296
C57BLKS/J m 182.0667 14.4305 210.4002 153.7331
C57BR/cdJ f 265.1 17.6737 299.8013 230.3987
C57BR/cdJ m 226.2 17.6737 260.9013 191.4987
C57L/J f 129.375 19.7598 168.1723 90.5777
C57L/J m 158.4444 18.6297 195.0229 121.866
C58/J f 331.2222 18.6297 367.8007 294.6438
C58/J m 498.0 17.6737 532.7013 463.2987
CAST/EiJ f 429.375 19.7598 468.1723 390.5777
CAST/EiJ m 295.0 18.6297 331.5784 258.4216
CBA/J f 100.7 17.6737 135.4013 65.9987
CBA/J m 176.2 17.6737 210.9013 141.4987
CE/J f 177.8889 18.6297 214.4673 141.3105
CE/J m 254.8333 22.8166 299.6326 210.0341
CZECHII/EiJ f 206.8571 21.1241 248.3332 165.3811
CZECHII/EiJ m 229.0 21.1241 270.476 187.524
DBA/1J f 130.0 21.1241 171.476 88.524
DBA/1J m 147.6667 18.6297 184.2451 111.0882
DBA/2J f 118.8889 18.6297 155.4673 82.3105
DBA/2J m 201.8333 22.8166 246.6326 157.0341
FVB/NJ f 176.9 17.6737 211.6013 142.1987
FVB/NJ m 238.6667 32.2676 302.0224 175.311
I/LnJ f 164.2 17.6737 198.9013 129.4987
I/LnJ m 165.1 17.6737 199.8013 130.3987
KK/HlJ f 295.75 19.7598 334.5473 256.9527
KK/HlJ m 188.5 19.7598 227.2973 149.7027
LP/J f 167.2222 18.6297 203.8007 130.6438
LP/J m 167.0 17.6737 201.7013 132.2987
MOLF/EiJ f 519.7143 21.1241 561.1903 478.2382
MOLF/EiJ m 685.5556 18.6297 722.134 648.9771
NOD/ShiLtJ f 311.0 18.6297 347.5784 274.4216
NOD/ShiLtJ m 302.8571 21.1241 344.3332 261.3811
NON/ShiLtJ f 200.8889 18.6297 237.4673 164.3105
NON/ShiLtJ m 260.6667 18.6297 297.2451 224.0882
NZB/BlNJ f 357.8182 16.8512 390.9046 324.7317
NZB/BlNJ m 332.8889 18.6297 369.4673 296.3105
NZW/LacJ f 224.5 19.7598 263.2973 185.7027
NZW/LacJ m 215.6667 18.6297 252.2451 179.0882
PERA/EiJ f 268.5 19.7598 307.2973 229.7027
PERA/EiJ m 294.5 27.9445 349.3676 239.6324
P/J f 272.2 17.6737 306.9013 237.4987
P/J m 240.3 17.6737 275.0013 205.5987
PL/J f 201.7778 18.6297 238.3562 165.1993
PL/J m 236.6667 32.2676 300.0224 173.311
RBF/DnJ f 489.2 17.6737 523.9013 454.4987
RBF/DnJ m 471.75 19.7598 510.5473 432.9527
RF/J f 155.6667 18.6297 192.2451 119.0882
RF/J m 173.5 22.8166 218.2992 128.7008
RIIIS/J f 170.1111 18.6297 206.6895 133.5327
RIIIS/J m 160.4444 18.6297 197.0229 123.866
SEA/GnJ f 193.5556 18.6297 230.134 156.9771
SEA/GnJ m 161.4 17.6737 196.1013 126.6987
SJL/J f 181.7 17.6737 216.4013 146.9987
SJL/J m 185.8889 18.6297 222.4673 149.3105
SM/J f 228.0 19.7598 266.7973 189.2027
SM/J m 255.0 22.8166 299.7992 210.2008
SPRET/EiJ f 165.5 22.8166 210.2992 120.7008
SPRET/EiJ m 120.8 24.9943 169.8751 71.7249
SWR/J f 219.7778 18.6297 256.3562 183.1993
SWR/J m 196.375 19.7598 235.1723 157.5777
WSB/EiJ f 234.75 19.7598 273.5473 195.9527
WSB/EiJ m 236.875 19.7598 275.6723 198.0777


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 225.35 12.4972 249.8876 200.8124
A/J both 302.9444 12.8396 328.1544 277.7345
AKR/J both 143.2278 12.8396 168.4377 118.0178
BALB/cJ both 153.0 12.4972 177.5376 128.4624
BPH/2J both 159.0486 13.5786 185.7095 132.3877
BPL/1J both 203.35 12.4972 227.8876 178.8124
BPN/3J both 189.4889 12.8396 214.6988 164.2789
BTBR T+ Itpr3tf/J both 188.9778 11.7824 212.112 165.8435
C3H/HeJ both 276.1375 13.2553 302.1635 250.1115
C57BL/10J both 161.9389 12.8396 187.1488 136.7289
C57BL/6J both 219.9 10.2039 239.9348 199.8652
C57BLKS/J both 178.1074 8.999 195.7765 160.4383
C57BR/cdJ both 245.65 12.4972 270.1876 221.1124
C57L/J both 143.9097 13.5786 170.5706 117.2488
C58/J both 414.6111 12.8396 439.8211 389.4012
CAST/EiJ both 362.1875 13.5786 388.8484 335.5266
CBA/J both 138.45 12.4972 162.9876 113.9124
CE/J both 216.3611 14.7281 245.2789 187.4433
CZECHII/EiJ both 217.9286 14.937 247.2566 188.6006
DBA/1J both 138.8333 14.0827 166.484 111.1826
DBA/2J both 160.3611 14.7281 189.2789 131.4433
FVB/NJ both 207.7833 18.3953 243.9016 171.665
I/LnJ both 164.65 12.4972 189.1876 140.1124
KK/HlJ both 242.125 13.9723 269.5588 214.6912
LP/J both 167.1111 12.8396 192.3211 141.9012
MOLF/EiJ both 602.6349 14.0827 630.2856 574.9842
NOD/ShiLtJ both 306.9286 14.0827 334.5793 279.2779
NON/ShiLtJ both 230.7778 13.1732 256.6426 204.9129
NZB/BlNJ both 345.3535 12.5601 370.0147 320.6924
NZW/LacJ both 220.0833 13.5786 246.7442 193.4224
PERA/EiJ both 281.5 17.1125 315.0994 247.9006
P/J both 256.25 12.4972 280.7876 231.7124
PL/J both 219.2222 18.6297 255.8007 182.6438
RBF/DnJ both 480.475 13.2553 506.501 454.449
RF/J both 164.5833 14.7281 193.5011 135.6655
RIIIS/J both 165.2778 13.1732 191.1426 139.4129
SEA/GnJ both 177.4778 12.8396 202.6877 152.2678
SJL/J both 183.7944 12.8396 209.0044 158.5845
SM/J both 241.5 15.0918 271.1319 211.8681
SPRET/EiJ both 143.15 16.9213 176.374 109.926
SWR/J both 208.0764 13.5786 234.7373 181.4155
WSB/EiJ both 235.8125 13.9723 263.2463 208.3787




  GWAS USING LINEAR MIXED MODELS