Project measure / variable:   Paigen1   bilesalts

ID, description, units MPD:2925   bilesalts   bile salts (plasma)   [µmol/L]  
high-fat diet study
Data set, strains Paigen1   inbred   43 strains     sex: both     age: 15-19wks
Procedure metabolic panel
Ontology mappings

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  STRAIN COMPARISON PLOT
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Paigen1 - bile salts (plasma)



  MEASURE SUMMARY
Measure Summary FemaleMale
Number of strains tested43 strains42 strains
Mean of the strain means60.7   µmol/L 73.0   µmol/L
Median of the strain means50.7   µmol/L 67.3   µmol/L
SD of the strain means± 36.7 ± 41.9
Coefficient of variation (CV)0.604 0.574
Min–max range of strain means13.3   –   177   µmol/L 17.4   –   201   µmol/L
Mean sample size per strain8.6   mice 7.8   mice


  ANOVA, Q-Q NORMALITY ASSESSMENT
ANOVA summary      
FactorDFSum of squaresMean sum of squaresF valuep value (Pr>F)
sex 1 4574.1021 4574.1021 4.6567 0.0313
strain 39 882604.4183 22630.8825 23.0395 < 0.0001
sex:strain 39 255373.5452 6548.0396 6.6663 < 0.0001
Residuals 617 606057.9095 982.2657


Q-Q normality assessment based on residuals

  


  STRAIN MEANS (UNADJUSTED)
  
Select table page:
Strain Sex Mean SD N mice SEM CV Min, Max Z score
129S1/SvImJ f 35.5 17.5   7 6.62 0.493 12.0, 62.2 -0.69
129S1/SvImJ m 60.7 13.7   10 4.33 0.226 39.3, 77.1 -0.29
A/J f 148.0 28.1   9 9.35 0.189 116.0, 191.0 2.38
A/J m 126.0 30.4   10 9.62 0.241 94.7, 175.0 1.26
AKR/J f 83.2 39.9   10 12.6 0.48 15.2, 152.0 0.61
AKR/J m 51.7 11.5   10 3.62 0.221 36.0, 70.2 -0.51
BALB/cJ f 54.9 16.8   10 5.3 0.305 23.7, 70.0 -0.16
BALB/cJ m 53.2 14.0   10 4.43 0.263 31.6, 73.6 -0.47
BPH/2J f 37.6 25.1   10 7.93 0.667 13.4, 86.8 -0.63
BPH/2J m 29.4 15.0   6 6.14 0.51 2.6, 44.5 -1.04
BPL/1J f 50.2 17.9   10 5.66 0.357 33.0, 95.6 -0.29
BPL/1J m 40.5 9.92   10 3.14 0.245 20.6, 53.1 -0.78
BPN/3J f 32.8 17.0   10 5.38 0.518 13.8, 67.0 -0.76
BPN/3J m 28.7 5.16   8 1.82 0.18 23.0, 38.4 -1.06
BTBR T+ Itpr3tf/J f 51.6 9.48   9 3.16 0.184 35.9, 61.8 -0.25
BTBR T+ Itpr3tf/J m 50.7 9.4   14 2.51 0.185 32.0, 63.5 -0.53
C3H/HeJ f 42.8 7.9   9 2.63 0.185 30.5, 55.4 -0.49
C3H/HeJ m 129.0 49.6   10 15.7 0.383 45.3, 199.0 1.34
C57BL/10J f 24.9 11.2   10 3.55 0.451 9.3, 46.6 -0.98
C57BL/10J m 82.3 14.6   10 4.63 0.178 59.7, 111.0 0.22
C57BL/6J f 51.9 17.7   16 4.43 0.342 20.8, 71.0 -0.24
C57BL/6J m 68.4 26.9   15 6.95 0.393 40.6, 130.0 -0.11
C57BLKS/J f 150.0 26.3   26 5.16 0.176 91.8, 189.0 2.43
C57BLKS/J m 66.8 29.6   15 7.65 0.444 23.0, 146.0 -0.15
C57BR/cdJ f 48.2 15.0   8 5.31 0.312 27.5, 70.2 -0.34
C57BR/cdJ m 49.0 11.9   9 3.96 0.243 30.1, 65.4 -0.57
C57L/J f 30.5 20.3   7 7.67 0.665 12.8, 65.5 -0.82
C57L/J m 40.8 10.8   8 3.8 0.264 27.6, 54.1 -0.77
C58/J f 140.0 41.7   10 13.2 0.299 71.6, 198.0 2.16
C58/J m 201.0 85.9   9 28.6 0.428 85.3, 350.0 3.05
CAST/EiJ f 13.3 0.0   1   0.0 0.0 13.3, 13.3 -1.29
CAST/EiJ m 75.8 0.0   1   0.0 0.0 75.8, 75.8 0.07
CBA/J f 25.5 8.81   10 2.79 0.346 10.0, 40.3 -0.96
CBA/J m 33.8 9.48   9 3.16 0.28 20.7, 45.1 -0.94
CE/J f 41.6 7.74   8 2.74 0.186 27.9, 54.6 -0.52
CE/J m 103.0 69.8   7 26.4 0.68 39.6, 229.0 0.72
CZECHII/EiJ f 67.1 33.2   5 14.8 0.494 29.9, 121.0 0.17
CZECHII/EiJ m 70.8 42.8   3 24.7 0.604 24.6, 109.0 -0.05
DBA/1J f 33.8 13.5   7 5.11 0.399 13.2, 54.5 -0.73
DBA/1J m 146.0 29.1   4 14.5 0.199 103.0, 166.0 1.74
DBA/2J f 58.1 20.7   9 6.89 0.356 28.4, 92.3 -0.07
DBA/2J m 73.0 8.06   6 3.29 0.11 64.1, 86.3 0.0
FVB/NJ f 61.9 11.3   10 3.56 0.182 43.5, 84.9 0.03
FVB/NJ m 106.0 68.8   3 39.7 0.651 55.3, 184.0 0.79
I/LnJ f 45.0 9.44   8 3.34 0.21 32.3, 62.8 -0.43
I/LnJ m 33.6 26.9   5 12.0 0.802 0.9, 60.2 -0.94
KK/HlJ f 177.0 52.2   9 17.4 0.295 127.0, 266.0 3.17
KK/HlJ m 152.0 46.9   7 17.7 0.308 62.5, 199.0 1.88
LP/J f 35.7 14.3   7 5.4 0.4 21.8, 56.4 -0.68
LP/J m 30.7 6.36   9 2.12 0.208 18.4, 37.9 -1.01
MOLF/EiJ f 82.9 55.8   5 24.9 0.673 10.8, 160.0 0.6
MOLF/EiJ m 167.0 112.0   9 37.5 0.672 26.1, 304.0 2.24
NOD/ShiLtJ f 84.4 21.4   9 7.12 0.253 44.1, 111.0 0.64
NOD/ShiLtJ m 71.9 37.7   6 15.4 0.524 24.6, 139.0 -0.03
NON/ShiLtJ f 51.0 20.6   10 6.52 0.405 14.8, 87.6 -0.26
NON/ShiLtJ m 54.9 15.9   10 5.04 0.291 33.5, 82.2 -0.43
NZB/BlNJ f 98.4 56.1   11 16.9 0.57 33.0, 244.0 1.03
NZB/BlNJ m 48.8 12.1   9 4.05 0.249 29.6, 63.7 -0.58
NZW/LacJ f 32.8 16.6   7 6.28 0.506 9.2, 64.4 -0.76
NZW/LacJ m 49.9 22.0   10 6.97 0.442 13.0, 77.9 -0.55
PERA/EiJ f 42.0 26.6   7 10.0 0.633 13.4, 82.7 -0.51
PERA/EiJ m 45.5 28.6   4 14.3 0.629 15.4, 78.4 -0.66
P/J f 39.5 10.6   9 3.55 0.27 20.3, 51.5 -0.58
P/J m 41.1 13.9   7 5.27 0.339 27.3, 66.7 -0.76
PL/J f 86.0 24.9   7 9.42 0.29 53.8, 125.0 0.69
PL/J m 147.0 138.0   3 79.4 0.934 63.1, 306.0 1.77
RBF/DnJ f 106.0 21.2   10 6.7 0.2 73.8, 135.0 1.23
RBF/DnJ m 72.1 21.8   8 7.69 0.302 42.3, 115.0 -0.02
RF/J f 31.5 10.4   10 3.28 0.329 16.6, 51.0 -0.8
RF/J m 63.1 20.9   6 8.53 0.331 24.1, 87.3 -0.24
RIIIS/J f 81.7 28.4   9 9.46 0.347 38.1, 128.0 0.57
RIIIS/J m 77.2 49.6   9 16.5 0.642 25.7, 176.0 0.1
SEA/GnJ f 24.4 9.83   8 3.47 0.402 10.6, 38.0 -0.99
SEA/GnJ m 25.4 9.85   8 3.48 0.388 12.6, 37.9 -1.14
SJL/J f 61.3 25.8   10 8.16 0.421 30.6, 106.0 0.02
SJL/J m 69.7 16.4   9 5.47 0.236 42.9, 94.5 -0.08
SM/J f 39.8 18.3   8 6.47 0.459 12.6, 68.1 -0.57
SM/J m 67.8 18.4   6 7.52 0.272 53.7, 97.4 -0.12
SPRET/EiJ f 46.1 34.7   3 20.0 0.753 11.0, 80.4 -0.4
SPRET/EiJ m 17.4 0.0   1   0.0 0.0 17.4, 17.4 -1.33
SWR/J f 50.7 8.85   9 2.95 0.175 41.2, 65.4 -0.27
SWR/J m 72.8 52.8   8 18.7 0.726 8.8, 150.0 -0.01
WSB/EiJ f 57.0 32.4   6 13.2 0.569 15.6, 94.7 -0.1
WSB/EiJ m 72.3 35.1   9 11.7 0.486 20.6, 129.0 -0.02
YBR/EiJ f 54.6 19.8   5 8.87 0.363 36.0, 88.4 -0.17


  LEAST SQUARES MEANS (MODEL-ADJUSTED)
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ f 35.5 11.8458 58.763 12.237
129S1/SvImJ m 60.7 9.9109 80.1632 41.2368
A/J f 148.1111 10.447 168.6272 127.595
A/J m 126.41 9.9109 145.8732 106.9468
AKR/J f 83.22 9.9109 102.6832 63.7568
AKR/J m 51.73 9.9109 71.1932 32.2668
BALB/cJ f 54.87 9.9109 74.3332 35.4068
BALB/cJ m 53.18 9.9109 72.6432 33.7168
BPH/2J f 37.6 9.9109 57.0632 18.1368
BPH/2J m 29.45 12.795 54.5769 4.3231
BPL/1J f 50.19 9.9109 69.6532 30.7268
BPL/1J m 40.54 9.9109 60.0032 21.0768
BPN/3J f 32.81 9.9109 52.2732 13.3468
BPN/3J m 28.7125 11.0808 50.4731 6.9519
BTBR T+ Itpr3tf/J f 51.5778 10.447 72.0938 31.0617
BTBR T+ Itpr3tf/J m 50.6714 8.3763 67.1209 34.222
C3H/HeJ f 42.7778 10.447 63.2938 22.2617
C3H/HeJ m 129.41 9.9109 148.8732 109.9468
C57BL/10J f 24.85 9.9109 44.3132 5.3868
C57BL/10J m 82.28 9.9109 101.7432 62.8168
C57BL/6J f 51.8938 7.8353 67.2808 36.5067
C57BL/6J m 68.4333 8.0922 84.325 52.5417
C57BLKS/J f 149.7231 6.1465 161.7937 137.6525
C57BLKS/J m 66.76 8.0922 82.6517 50.8683
C57BR/cdJ f 48.2 11.0808 69.9606 26.4394
C57BR/cdJ m 49.0222 10.447 69.5383 28.5062
C57L/J f 30.5429 11.8458 53.8059 7.2798
C57L/J m 40.7625 11.0808 62.5231 19.0019
C58/J f 139.56 9.9109 159.0232 120.0968
C58/J m 200.8111 10.447 221.3272 180.295
CBA/J f 25.48 9.9109 44.9432 6.0168
CBA/J m 33.8222 10.447 54.3383 13.3062
CE/J f 41.5625 11.0808 63.3231 19.8019
CE/J m 102.5714 11.8458 125.8345 79.3084
CZECHII/EiJ f 67.1 14.0162 94.6252 39.5748
CZECHII/EiJ m 70.8 18.0948 106.3349 35.2651
DBA/1J f 33.8429 11.8458 57.1059 10.5798
DBA/1J m 146.25 15.6706 177.0241 115.4759
DBA/2J f 58.0667 10.447 78.5827 37.5506
DBA/2J m 72.9667 12.795 98.0936 47.8397
FVB/NJ f 61.88 9.9109 81.3432 42.4168
FVB/NJ m 105.6333 18.0948 141.1682 70.0985
I/LnJ f 44.9875 11.0808 66.7481 23.2269
I/LnJ m 33.58 14.0162 61.1052 6.0548
KK/HlJ f 177.0 10.447 197.5161 156.4839
KK/HlJ m 152.3571 11.8458 175.6202 129.0941
LP/J f 35.7286 11.8458 58.9916 12.4655
LP/J m 30.6556 10.447 51.1716 10.1395
MOLF/EiJ f 82.86 14.0162 110.3852 55.3348
MOLF/EiJ m 167.4 10.447 187.9161 146.8839
NOD/ShiLtJ f 84.4222 10.447 104.9383 63.9062
NOD/ShiLtJ m 71.9 12.795 97.0269 46.7731
NON/ShiLtJ f 50.96 9.9109 70.4232 31.4968
NON/ShiLtJ m 54.86 9.9109 74.3232 35.3968
NZB/BlNJ f 98.4455 9.4497 117.0029 79.888
NZB/BlNJ m 48.7778 10.447 69.2938 28.2617
NZW/LacJ f 32.8 11.8458 56.063 9.537
NZW/LacJ m 49.85 9.9109 69.3132 30.3868
PERA/EiJ f 41.9857 11.8458 65.2487 18.7227
PERA/EiJ m 45.475 15.6706 76.2491 14.7009
P/J f 39.4778 10.447 59.9938 18.9617
P/J m 41.1429 11.8458 64.4059 17.8798
PL/J f 85.9571 11.8458 109.2202 62.6941
PL/J m 147.3 18.0948 182.8349 111.7651
RBF/DnJ f 105.89 9.9109 125.3532 86.4268
RBF/DnJ m 72.1 11.0808 93.8606 50.3394
RF/J f 31.49 9.9109 50.9532 12.0268
RF/J m 63.0833 12.795 88.2103 37.9564
RIIIS/J f 81.6667 10.447 102.1827 61.1506
RIIIS/J m 77.1556 10.447 97.6716 56.6395
SEA/GnJ f 24.425 11.0808 46.1856 2.6644
SEA/GnJ m 25.4 11.0808 47.1606 3.6394
SJL/J f 61.27 9.9109 80.7332 41.8068
SJL/J m 69.6556 10.447 90.1716 49.1395
SM/J f 39.8125 11.0808 61.5731 18.0519
SM/J m 67.75 12.795 92.8769 42.6231
SWR/J f 50.7 10.447 71.2161 30.1839
SWR/J m 72.775 11.0808 94.5356 51.0144
WSB/EiJ f 57.0 12.795 82.1269 31.8731
WSB/EiJ m 72.2667 10.447 92.7827 51.7506


  LEAST SQUARES MEANS (MODEL-ADJUSTED), SEXES COMBINED
Strain Sex Mean SEM UpperCL LowerCL
129S1/SvImJ both 48.1 7.7225 63.2656 32.9344
A/J both 137.2606 7.2001 151.4003 123.1208
AKR/J both 67.475 7.0081 81.2376 53.7124
BALB/cJ both 54.025 7.0081 67.7876 40.2624
BPH/2J both 33.525 8.0922 49.4167 17.6333
BPL/1J both 45.365 7.0081 59.1276 31.6024
BPN/3J both 30.7613 7.4332 45.3587 16.1638
BTBR T+ Itpr3tf/J both 51.1246 6.6952 64.2727 37.9765
C3H/HeJ both 86.0939 7.2001 100.2336 71.9542
C57BL/10J both 53.565 7.0081 67.3276 39.8024
C57BL/6J both 60.1635 5.632 71.2237 49.1034
C57BLKS/J both 108.2415 5.0809 118.2196 98.2635
C57BR/cdJ both 48.6111 7.6145 63.5646 33.6576
C57L/J both 35.6527 8.1103 51.5798 19.7256
C58/J both 170.1856 7.2001 184.3253 156.0458
CBA/J both 29.6511 7.2001 43.7908 15.5114
CE/J both 72.067 8.1103 87.9941 56.1399
CZECHII/EiJ both 68.95 11.4442 91.4242 46.4758
DBA/1J both 90.0464 9.822 109.3351 70.7577
DBA/2J both 65.5167 8.2591 81.736 49.2973
FVB/NJ both 83.7567 10.3156 104.0147 63.4987
I/LnJ both 39.2838 8.9336 56.8277 21.7398
KK/HlJ both 164.6786 7.8972 180.1873 149.1699
LP/J both 33.1921 7.8972 48.7008 17.6834
MOLF/EiJ both 125.13 8.7406 142.295 107.965
NOD/ShiLtJ both 78.1611 8.2591 94.3805 61.9417
NON/ShiLtJ both 52.91 7.0081 66.6726 39.1474
NZB/BlNJ both 73.6116 7.0434 87.4435 59.7797
NZW/LacJ both 41.325 7.7225 56.4906 26.1594
PERA/EiJ both 43.7304 9.822 63.019 24.4417
P/J both 40.3103 7.8972 55.819 24.8016
PL/J both 116.6286 10.8137 137.8647 95.3924
RBF/DnJ both 88.995 7.4332 103.5924 74.3976
RF/J both 47.2867 8.0922 63.1783 31.395
RIIIS/J both 79.4111 7.3872 93.9182 64.9041
SEA/GnJ both 24.9125 7.8353 40.2995 9.5255
SJL/J both 65.4628 7.2001 79.6025 51.3231
SM/J both 53.7812 8.4631 70.4012 37.1613
SWR/J both 61.7375 7.6145 76.691 46.784
WSB/EiJ both 64.6333 8.2591 80.8527 48.414




  GWAS USING LINEAR MIXED MODELS