Donahue1: Bone mineral density, body composition, and craniofacial characterization in 30 inbred strains of mice (2002)

Li R, Svenson KL, Donahue LR, Peters LL, Churchill GA. Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels. Physiol Genomics. 2008 Mar 14;33(1):26-32. Epub 2008 Jan 29.   PubMed 18230669  


       
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Participants Leah Rae Donahue       The Jackson Laboratory Bar Harbor, ME
With: DeMombro V, Maynard J, Bauschatz J, Hurd J, Marden C, Curtain M
ContactLeah Rae Donahue     lrd@jax.org     Lab web site
AcknowledgementsFunding provided by NIH DE13078; Department of the Army Grant DAMD17-03-1-0773

Generous funds from Hoffmann-LaRoche, Inc. were used to defray the cost of mice through the Mouse Phenome Project.
Project type Phenotype strain survey data set
MPD identifiersDonahue1     MPD:115
Data changelog 2 updates/corrections.       Initial release date: 05/2008.
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Animals were assessed using densitometer dual energy X-ray absorptiometry (DXA) system. Several hormonal markers for bone growth and metabolism were also assayed.

Summary of procedures that were conducted
• DXA Body mass, fat mass, lean mass, bone mineral density and content, craniofacial dimensions.
• metabolic panel Thyroxine (serum).
• hormone quantification Osteocalcin, insulin-like growth factor 1.
Mice: inbred w/CC7   30 strains   ♀♂   age 15-16wks   1 cohort

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Data set MPD ID Procedure / Protocol Drug or Challenge Phenotype Measure Panel No. of Strains Sex Age Sample Size (Avg)
    Donahue1 11506 DXA (none) whole body bone mineral density (BMD)   [g/cm2]  body_BMD inbred w/CC7 30 both 15-16wks N=10
    Donahue1 11508 DXA (none) whole body bone mineral content (BMC)   [g]  body_BMC inbred w/CC7 30 both 15-16wks N=10
    Donahue1 11510 DXA (none) lean body tissue mass, head excluded   [g]  lean_wt inbred w/CC7 30 both 15-16wks N=10
    Donahue1 11512 DXA (none) weight of fat portion of body mass, head excluded   [g]  fat_wt inbred w/CC7 30 both 15-16wks N=10
    Donahue1 11514 DXA (none) total tissue mass, head excluded   [g]  total_wt inbred w/CC7 30 both 15-16wks N=10
    Donahue1 11515 DXA (none) percent of body mass that is fat, head excluded   [%]  pct_fat inbred w/CC7 30 both 15-16wks N=10
    Donahue1 11516 DXA (none) spine (L2-L5) bone mineral density (BMD)   [g/cm2]  spine_BMD inbred w/CC7 30 both 15-16wks N=10
    Donahue1 11517 DXA (none) skull bone mineral density (BMD)   [g/cm2]  skull_BMD inbred w/CC7 30 both 15-16wks N=10
    Donahue1 11518 DXA (none) total skull length   [mm]  skull_length inbred w/CC7 29 both 15-16wks N=9
    Donahue1 11519 DXA (none) nose length   [mm]  nose_length inbred w/CC7 29 both 15-16wks N=9
    Donahue1 11520 DXA (none) skull height   [mm]  skull_height inbred w/CC7 29 both 15-16wks N=9
    Donahue1 11521 DXA (none) skull width   [mm]  skull_width inbred w/CC7 29 both 15-16wks N=9
    Donahue1 11522 DXA (none) inner canthal distance   [mm]  inner_canthal inbred w/CC7 29 both 15-16wks N=9
    Donahue1 11523 DXA (none) length of upper jaw   [mm]  upper_jaw inbred w/CC7 29 both 15-16wks N=9
    Donahue1 11524 DXA (none) length of lower jaw   [mm]  lower_jaw inbred w/CC7 29 both 15-16wks N=9
    Donahue1 11530 hormone quantification (none) osteocalcin (serum OC)   [ng/mL]  osteocalcin inbred w/CC7 30 both 15-16wks N=9
    Donahue1 11531 metabolic panel (none) thyroxine (serum T4)   [µg/dL]  thyroxine inbred w/CC7 29 both 15-16wks N=9
    Donahue1 11532 hormone quantification (none) insulin-like growth factor 1 (adjusted serum IGF-1)   [ng/mL]  IGF_1 inbred w/CC7 30 both 15-16wks N=9
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