MPD: Data set: Donahue1

Li R, Svenson KL, Donahue LR, Peters LL, Churchill GA. Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels. Physiol Genomics. 2008 Mar 14;33(1):26-32. Epub 2008 Jan 29. PubMed 18230669

Animals were assessed using densitometer dual energy X-ray absorptiometry (DXA) system. Several hormonal markers for bone growth and metabolism were also assayed.

Procedures conducted:

• DXA		Body mass, fat mass, lean mass, bone mineral density and content, craniofacial dimensions.
• metabolic panel		Thyroxine (serum).
• hormone quantification		Osteocalcin, insulin-like growth factor 1.

Donahue1 downloads
• Download Donahue1 project data set animal data, as uploaded
• Download Donahue1 animal data matrix with factor-related expansion applied as necessary
• Download Donahue1 strain means, SD, N, etc. one row per strain/sex/measure

Ontology terms mapped to Donahue1 measures:

MA:0000009 adipose tissue
MA:0000316 cranium
MA:0001459 bone
MA:0002502 serum
MP:0000428 abnormal craniofacial morphology
MP:0002089 abnormal postnatal growth/weight/body size
MP:0002116 abnormal craniofacial bone morphology
MP:0003959 abnormal lean body mass
MP:0004700 abnormal circulating insulin-like growth factor I level
MP:0005452 abnormal adipose tissue amount
MP:0005457 abnormal percent body fat/body weight
MP:0005475 abnormal circulating thyroxine level
MP:0010119 abnormal bone mineral density
MP:0010122 abnormal bone mineral content
MP:0011922 abnormal circulating osteocalcin level
MP:0012321 abnormal total tissue mass
VT:0000454 jaw morphology trait
VT:0000458 mandible morphology trait
VT:0001259 body mass
VT:0002116 craniofacial bone morphology trait
VT:0003104 skull size trait
VT:0005007 bone mineral mass
VT:0005452 adipose amount
VT:0005475 blood thyroxine amount
VT:0010479 blood insulin-like growth factor amount
VT:0010480 blood osteocalcin amount
VT:0010482 body fat mass
VT:0010483 body lean mass

Investigators	Leah Rae Donahue The Jackson Laboratory, Bar Harbor, ME
Participants	DeMombro V, Maynard J, Bauschatz J, Hurd J, Marden C, Curtain M
Contact	Leah Rae Donahue lrd@jax.org Lab web site
Acknowledgements	Funding provided by NIH DE13078; Department of the Army Grant DAMD17-03-1-0773 Generous funds from Hoffmann-LaRoche, Inc. were used to defray the cost of mice through the Mouse Phenome Project.
Project type	Phenotype strain survey data set
MPD identifiers	Donahue1 MPD:115
Data changelog	2 updates/corrections. Initial release date: 05/2008.
Formatted citation	Click above to copy-paste the entire citation for this MPD web page.

Sort/ Pick	Data set	Procedure / Protocol	Treatment	Phenotype Measure / Variable (click to view)	Panel	No. of Strains	Sex	Age	Sample Size (Avg)
Donahue1:1	Donahue1	DXA	(none)	whole body bone mineral density (BMD) [g/cm²] body_BMD 11506	inbred w/CC7	30	both	15-16wks	N=10

Donahue1:2	Donahue1	DXA	(none)	whole body bone mineral content (BMC) [g] body_BMC 11508	inbred w/CC7	30	both	15-16wks	N=10

Donahue1:3	Donahue1	DXA	(none)	lean body tissue mass, head excluded [g] lean_wt 11510	inbred w/CC7	30	both	15-16wks	N=10

Donahue1:4	Donahue1	DXA	(none)	weight of fat portion of body mass, head excluded [g] fat_wt 11512	inbred w/CC7	30	both	15-16wks	N=10

Donahue1:5	Donahue1	DXA	(none)	total tissue mass, head excluded [g] total_wt 11514	inbred w/CC7	30	both	15-16wks	N=10

Donahue1:6	Donahue1	DXA	(none)	percentage of body mass that is fat, head excluded [%] pct_fat 11515	inbred w/CC7	30	both	15-16wks	N=10

Donahue1:7	Donahue1	DXA	(none)	spine (L2-L5) bone mineral density (BMD) [g/cm²] spine_BMD 11516	inbred w/CC7	30	both	15-16wks	N=10

Donahue1:8	Donahue1	DXA	(none)	skull bone mineral density (BMD) [g/cm²] skull_BMD 11517	inbred w/CC7	30	both	15-16wks	N=10

Donahue1:9	Donahue1	DXA	(none)	total skull length [mm] skull_length 11518	inbred w/CC7	29	both	15-16wks	N=9

Donahue1:10	Donahue1	DXA	(none)	nose length (craniofacial) [mm] nose_length 11519	inbred w/CC7	29	both	15-16wks	N=9

Donahue1:11	Donahue1	DXA	(none)	skull height [mm] skull_height 11520	inbred w/CC7	29	both	15-16wks	N=9

Donahue1:12	Donahue1	DXA	(none)	skull width [mm] skull_width 11521	inbred w/CC7	29	both	15-16wks	N=9

Donahue1:13	Donahue1	DXA	(none)	inner canthal distance [mm] inner_canthal 11522	inbred w/CC7	29	both	15-16wks	N=9

Donahue1:14	Donahue1	DXA	(none)	length of upper jaw [mm] upper_jaw 11523	inbred w/CC7	29	both	15-16wks	N=9

Donahue1:15	Donahue1	DXA	(none)	length of lower jaw [mm] lower_jaw 11524	inbred w/CC7	29	both	15-16wks	N=9

Donahue1:16	Donahue1	hormone quantification	(none)	osteocalcin (serum OC) [ng/mL] osteocalcin 11530	inbred w/CC7	30	both	15-16wks	N=9

Donahue1:17	Donahue1	metabolic panel	(none)	thyroxine (serum T4) [µg/dL] thyroxine 11531	inbred w/CC7	29	both	15-16wks	N=9

Donahue1:18	Donahue1	hormone quantification	(none)	insulin-like growth factor 1 (adjusted serum IGF-1) [ng/mL] IGF_1 11532	inbred w/CC7	30	both	15-16wks	N=9

Donahue1: Bone mineral density, body composition, and craniofacial characterization in 30 inbred strains of mice (2002)